Results 231 to 240 of about 621,434 (269)

Solid‐Phase Synthesis of Sialyl Tn Antigen

Journal of Carbohydrate Chemistry, 2006
Solid‐phase synthesis of sialyl Tn [α‐Neu5Ac‐(2→6)‐α‐GalNAc‐(1→O)‐Ser] antigen with Kenner's acylsulfonamide linker is described. The acylsulfonamide bond was found to be stable under glycosylation reactions using dimethyl(methylthio)sulfonium triflate (DMTST) as a promoter and basic conditions used for the removal of protecting groups. The solid‐phase
Takuya Kanemitsu, Shusaku Daikoku, Osamu Kanie   +2 more
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Expression of Sialosyl Tn Antigen in Gastric Cancer

1993
Expression of sialosyl Tn antigen (STN) of surgically resected spesimens in human gastric cancers, using the monoclonal antibody (TKH-2), was evaluated immunohistochemically in 42 patients measured serum STN level and in 45 patients with advanced cancer followed over five years after gastrectomy. Staining intensity was graded as follows: (-), less than
Takashi Yamada, Akihiko Watanabe, Hidetomo Sawada, Yukishige Yamada, Tomoaki Yano, Naoto Ueyama, Yoshihide Shino, Masahiro Tanase, Hiroshige Nakano   +8 more
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Serum Sialyl-Tn Antigen Levels in Patients with Digestive Cancers

Oncology, 2009
Serum levels of sialyl-Tn antigen (STN) were measured using a one-step radioimmunoassay kit in 257 patients with digestive cancers, 121 patients with benign digestive diseases, and in 64 healthy controls. With 45 U/ml regarded as the cutoff value, the positive rates of serum STN in digestive cancers were as follows: pancreas 40.0%, stomach 28.1, colon ...
Y, Motoo, H, Kawakami, H, Watanabe, Y, Satomura, H, Ohta, T, Okai, H, Makino, D, Toya, N, Sawabu   +8 more
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Expression of Tn and Sialyl-Tn Antigens in Tumor Tissues of the Ovary

American Journal of Clinical Pathology, 1991
The expression of sialyl-Tn and Tn antigens in various benign, borderline, and malignant ovarian tumors was examined immunohistochemically using newly developed antibodies specific for sialyl-Tn and Tn antigens. Sialyl-Tn antigen was detected in only one benign tumor, a mucinous adenoma that showed faint cytoplasmic staining in a few cells.
M, Inoue, S M, Ton, H, Ogawa, O, Tanizawa   +3 more
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Das Tn-Antigen: Substruktur von T.

1974
Entsprechend den in Abb.2 und Abb.3 dargestellten Schemata konnte unsere Arbeitsgruppe durch gaschromatographische Untersuchungen (Abb.l0 u. 11) zeigen, das bet dieser Anomalie der Aufbau der MN Blutgruppenantigene in der Weise gestort ist, das durch das Fehlen einer Galaktosyltransferase und auch einer Neuraminyltransferase das MN Tetrasaccharid nur ...
Gerhard Uhlenbruck, Wolfgang Dahr, Almut Rothe, Brian Baldo, Rudolf Gross   +4 more
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Expression of the Tn antigen on T-lymphoid cell line Jurkat

Biochemical and Biophysical Research Communications, 1991
Expression of the Tn antigen on a T-lymphoid cell line, Jurkat, was investigated using an anti-Tn monoclonal antibody, MLS 128. Immunoprecipitation or immunoaffinity chromatography of a lysate of Jurkat cells led to the isolation of a 120 kDa glycoprotein carrying the Tn antigen.
H, Nakada, M, Inoue, N, Tanaka, Y, Numata, H, Kitagawa, S, Fukui, I, Yamashina   +6 more
openaire   +2 more sources

Synthetic carbohydrate vaccines: Synthesis and immunogenicity of Tn antigen conjugates

Bioorganic & Medicinal Chemistry, 1994
A tumor-associated carbohydrate antigen, Tn antigen (GalNAc alpha 1-->O-Ser), was synthesized with a spacer arm, and assembled to dimeric and trimeric structures using N-tert-butyloxycarbonyl-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha- D-galactopyranosyl)-L-serine as a key building block.
T, Toyokuni, S, Hakomori, A K, Singhal
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The solution conformation of C-glycosyl analogues of the sialyl-Tn antigen

Carbohydrate Research, 2007
The conformational behavior of two C-glycosyl analogues of the sialyl-Tn antigen has been determined by a combination of NMR methods and molecular mechanics calculations. Both compounds show a major solution conformation that is drastically different from the major one of the natural compound.
Víctor, García-Aparicio, Adeline, Malapelle, Zouleika, Abdallah, Gilles, Doisneau, José Ignacio, Santos, Juan Luis, Asensio, Francisco Javier, Cañada, Jean Marie, Beau, Jesús, Jiménez-Barbero   +8 more
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[Expression of T and Tn antigens in breast cancers].

Comptes rendus des seances de la Societe de biologie et de ses filiales, 1999
Expression of carcinoembryonic Tn antigen studied with VVA-B4 and GSI-A4 lectins with the monoclonal antibody 83D4 and of T antigen with LDL and PNA lectins with the monoclonal antibody ZCMO4, were examined in 54 malignant or benign human breast tumors and for MCF-7, T47D and MCF-10A cell lines of human breast tumors origin.
G, Konska, D, Favy, J, Guillot, D, Bernard-Gallon, M, de Latour, Y, Fonck   +5 more
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Critical care management of chimeric antigen receptor T-cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Sandrine Valade, Peter Schellongowski, Alexander Shimabukuro-Vornhagen   +2 more
exaly