Results 91 to 100 of about 74,225 (263)

Combined retrospective analyses of 306 TNBC tumors treated with neoadjuvant chemotherapy stratified by molecular subtype.

, 2016
Barplots show pCR for (A) all breast cancer stratified by non-TNBC and TNBC or (B) TNBC patients stratified by PAM50 or (C) TNBCtype-4. Dotted horizontal lines indicate pCR for the stratified individual cohort.
Harold L. Moses (28594), Jennifer A. Pietenpol (737693), Brian D. Lehmann (737692), Bojana Jovanović (2838500), Monica V. Estrada (2838497), Xi Chen (35903), Yu Shyr (28592), Kimberly N. Johnson (2838503), Melinda E. Sanders (1286418)   +8 more
core   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source

Therapeutic Advantage of Targeting PRMT5 in Combination with Chemotherapies or EGFR/HER2 Inhibitors in Triple-Negative Breast Cancers

Breast Cancer: Targets and Therapy, 2023
Rayan Dakroub,1,2 Solène Huard,1 Yara Hajj-Younes,1 Samyuktha Suresh,1 Bassam Badran,2 Hussein Fayyad-Kazan,2 Thierry Dubois1 1Breast Cancer Biology Group, Translational Research Department, Institut Curie-PSL Research University, Paris, 75005, France ...
Dakroub R, Huard S, Hajj-Younes Y, Suresh S, Badran B, Fayyad-Kazan H, Dubois T   +6 more
doaj  

SOX30 Facilitates Triple‐Negative Breast Cancer Metastasis via TNFR2–NF‐κB Signaling and Tumor Microenvironment Remodeling

Advanced Science, EarlyView.
SOX30 drives triple‐negative breast cancer (TNBC) metastasis through a dual mechanism: direct activation of the TNFR2/NF‐κB signaling cascade and subsequent CCL20‐mediated recruitment of tumor‐associated macrophages (TAMs) into the tumor microenvironment.
Pingping Gao, Na Sun, Ning Yang, Tingting Zhao, Rui Fu, Zhenyu Wu, Yuqin Zhou, Xuanni Tan, Yi Zhang, Fei Han, Xiaowei Qi   +10 more
wiley   +1 more source

Chemotherapy in early-stage* TNBC patients.

, 2018
Chemotherapy in early-stage* TNBC patients.
Piti Pornpraserthsuk (6103157), Areewan Somwangprasert (6103166), Youwanush Kongdan (6103160), Luangyot Thongthieang (6103175), Chulaporn Jatuparisuthi (6103169), Puttisak Puttawibul (146418), Mawin Vongsaisuwan (6103172), Chanyoot Bandidwattanawong (6103178), Teerayuth Namkanisorn (6103163), Arkom Chaiwerawattana (205225), Vichien Srimuninnimit (6103154), Chaturong Tantimongkolsuk (6103181)   +11 more
core   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Targeting STAT3 in TNBC Drug Resistance [PDF]

Triple negative breast cancer (TNBC) is one of the most aggressive types of breast cancer and lacks the three commonly targeted receptors in breast cancer treatments. As a result of a lack of targetable receptors, the standard of care remains to be harsh
Henry, Madison A.
core   +1 more source

Advances in Single-Cell Sequencing Technology and Its Applications in Triple-Negative Breast Cancer

Breast Cancer: Targets and Therapy, 2022
Meng Li, Tingting Yan, Miaozhou Wang, Yanqiu Cai, Yingyuan Wei Graduate School of Qinghai University, Qinghai University, Xining, Qinghai Province, People’s Republic of ChinaCorrespondence: Miaozhou Wang, Email wangmiaozhou@163.comAbstract: Triple ...
Li M, Yan T, Wang M, Cai Y, Wei Y
doaj  

Sonogenetics Nanomedicine Activates the cGAS‐STING Pathway for Immunotherapy of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song, Yan Liu, Shifeng Zhao, Cheng Zhu, Hongchang Guo, Jin Chang, Jun Kang   +6 more
wiley   +1 more source

PDZK1 suppresses TNBC development and sensitizes TNBC cells to erlotinib via the EGFR pathway

Epidermal growth factor receptor (EGFR)-targeted drugs (erlotinib, etc.) are used to treat multiple types of tumours. EGFR is highly expressed in most triple-negative breast cancer (TNBC) patients.
Yuanzhen Ma, Yuke Mao, Zhiyu Fang, Hongning Zhang, Yijun Qi, Junfang Zheng   +5 more
core   +1 more source