Results 81 to 90 of about 82,941 (302)

Zurich Consensus: Statement of German Experts on St. Gallen Conference 2011 on Primary Breast Cancer (Zurich 2011) [PDF]

, 2011
Every 2 years, the International Consensus Conference on the Treatment of Primary Breast Cancer takes place in St. Gallen. Given that the concept of the St.
Beckmann, Matthias W., Blohmer, Jens-Uwe, Costa, Serban-Dan, Diedrich, Klaus, Diel, Ingo, Eiermann, Wolfgang, Friese, Klaus, Gerber, Bernd, Harbeck, Nadia, Hilfrich, Jörn, Jackisch, Christian, Janni, Wolfgang, Jonat, Walter, Jänicke, Fritz, Kaufmann, Manfred, Kiechle, Marion, Kreienberg, Rolf, Köhler, Uwe, Maass, Nicolai, Marschner, Norbert, Minckwitz, Gunter von, Möbus, Volker, Nitz, Ulrike, Scharl, Anton, Schneeweiss, Andreas, Thomssen, Christoph, Untch, Michael, Wallwiener, Diethelm   +27 more
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Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Antiproliferative effects of cetuximab on triple negative breast cancer cell line MDA-MB-231

Cumhuriyet Science Journal, 2020
In this study, antiproliferative effects of the anti-EGFR monoclonal antibody Cetuximab were evaluated using MDA-MB-231 cell line originated from triple negative breast cancer.
İdil Çetin
doaj   +1 more source

Multiphoton Imaging of Labeled Breast Cancer Cells to Quantify Intra and Extracellular Receptors [PDF]

, 2016
Every year 200,000 women in the United States are diagnosed with breast cancer. Of the cases diagnosed, 10% -15% are classified as triple negative breast cancer (TNBC) due to the absence of estrogen, progesterone, and HER-2/Neu receptors.
Wiggins, Sydney C
core   +2 more sources

Subharmonic gap structures and Josephson effect in MgB2/Nb micro-constrictions

, 2005
Superconducting micro-constrictions between Nb tips and high quality MgB$_{2}$ pellets have been realized by means of a point-contact inset, driven by a micrometric screw.
Aprili, Marco, Bobba, Fabrizio, Cucolo, Anna Maria, Giubileo, Filippo, Piano, Samanta, Scarfato, Alessandro   +5 more
core   +3 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Phosphorylation of androgen receptors at serine 515 is a potential prognostic marker for triple negative breast cancer [PDF]

, 2017
1.7 million cases of breast cancer are diagnosed every year with 522,000 deaths. Molecular classifications of breast cancer have resulted in improved treatments. However, treatments for triple negative breast cancer (TNBC) are lacking.
Edwards, Joanne, Liew, Benjamin, Lim, Zhi, Mallon, Elizabeth A., McCall, Pamela, Roseweir, Antonia K., Scott, Alison   +6 more
core   +2 more sources

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Co-Delivery Nanomicelles for Potentiating TNBC Immunotherapy by Synergetically Reshaping CAFs-Mediated Tumor Stroma and Reprogramming Immunosuppressive Microenvironment

International Journal of Nanomedicine, 2023
Yue Zhang,1,* Xue Han,1,* Ke Wang,1 Da Liu,1 Xiaoyun Ding,2 Zhiqiang Hu,2 Jing Wang1,3 1School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, People’s Republic of China; 2Oncology Hospital, General Hospital of Ningxia Medical ...
Zhang Y, Han X, Wang K, Liu D, Ding X, Hu Z, Wang J   +6 more
doaj  

Combination Therapies of Guadecitabine and Immune Checkpoint Inhibitors in a Murine Triple-Negative Breast Cancer Model [PDF]

, 2020
Combination Therapies of Guadecitabine and Immune Checkpoint Inhibitors in a Murine Triple-Negative Breast Cancer Model Jamie-Jean Gilmer, Depts. of Biology and Chemistry, with Dr. Sarah Golding, Dept.
Gilmer, Jamie-Jean
core   +1 more source