Results 101 to 110 of about 51,359 (249)

Black phosphorus‐based photothermal disruption of cancer‐associated fibroblast barriers and tumor‐associated macrophage targeting to enhance anti‐PD‐L1 immunotherapy in triple‐negative breast cancer

Interdisciplinary Medicine, EarlyView.
MBB modulates the TNBC tumor microenvironment by targeting TAM/CXCL1 and facilitates anti‐PD‐L1 therapy by disrupting CAF barriers via its photothermal effect. This combined strategy subsequently enhances the efficacy of PD‐L1 mAb and suppresses TNBC progression, metastasis, and recurrence.
Bo Pan, Shicui Hong, Xinyue Wang, Yanghang Li, Cai Wang, Yaxiao Liu, Ying Chen, Chen Fang, Yifeng Zheng, Shengqi Wang, Juping Zhang, Neng Wang, Zhiyu Wang   +12 more
wiley   +1 more source

Programmed Cell Death Ligand 1 (PD-L1) and major Histocompatibility Complex Class I (MHC Class I) Expression Patterns and Their Pathologic Associations in triple-Negative Breast Cancer

Breast Cancer: Targets and Therapy
Ponkrit Kaewkedsri,1 Piyapharom Intarawichian,1 Sirawich Jessadapattarakul,1 Waritta Kunprom,1 Supinda Koonmee,1 Malinee Thanee,1 Ongart Somintara,2 Anongporn Wongbuddha,2 Payia Chadbunchachai,3 Supajit Nawapun,3 Chaiwat Aphivatanasiri1 1Department of ...
Kaewkedsri P, Intarawichian P, Jessadapattarakul S, Kunprom W, Koonmee S, Thanee M, Somintara O, Wongbuddha A, Chadbunchachai P, Nawapun S, Aphivatanasiri C   +10 more
doaj  

Chitosan nanoparticle‐mediated delivery of anti‐miR‐203a‐3p for 4T1 triple‐negative breast cancer

Indonesian Journal of Biotechnology
Anti‐miR molecules can suppress specific microRNA (miRNA) functions within critical signaling pathways. Chitosan acts as a delivery system for miRNAs; therefore, encapsulating miR‐203a‐3p is essential for targeted delivery and biological activity.
Jecklyn Shindy Temartenan, Hairil Fiqri, Pamungkas Bagus Satriyo, Sofia Mubarika Haryana   +3 more
doaj   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Quinoxaline amino derivatives as potential EGFR-targeted therapeutics in breast cancer: computational exploration

Journal of Applied Pharmaceutical Research
Background: Despite resistance to current tyrosine kinase inhibitors, which makes the epidermal growth factor receptor (EGFR) a recognized therapeutic target in breast cancer, there is a need for novel inhibitors.
Abitha H, D. Kumudha, Bhuvaneswari Sivaraman, M. K. Kathiravan   +3 more
doaj   +1 more source

Phosphatase activation in TNBC.

Phosphatases were present both in small and large quantities, and activated in resistance. PTPRU, PTPRN, PTPRO, ENPP2, and PPP2R2C were among the phosphatases most dramatically activated. 
openaire   +2 more sources

Application of MR Cytometry in Predicting Pathologic Complete Response to Neoadjuvant Chemotherapy in Breast Cancer: A Comparative Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background MR cytometry imaging is developed to characterize in vivo microstructures. Its clinical value in predicting pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) for breast cancer remains unknown. Purpose To implement MR cytometry to predict pCR for breast cancer and compare the performance of different ...
Jie Ding, Diwei Shi, Shiyun Sun, Jinlong Zheng, Wentao Yang, Caixia Fu, Dazhi Chen, Junzhong Xu, Hua Guo, Chao You, Yajia Gu   +10 more
wiley   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Loss of immunosurveillance in TNBC.

This paper describes cardinal changes in innate and adaptive immunity and natural killer cell function in TNBC. We previously described other aspects of immunodeficiency in TNBC including deficiency in IL2RG.
openaire   +3 more sources

Racial Differences in Breast Cancer Treatment and Information Access

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Persistent disparities in breast cancer (BC) care highlight the need to better understand patient experiences across diverse populations. This study examined racial differences in BC treatment, BR decisions, and social media use.
Tokoya Williams, May X. Li, Keenan S. Fine, Bradley A. Melnick, Kelly C. Ho, Johna Joseph, Jayla Allums, Rolando J. Casas Fuentes, Brigid M. Coles, Robert D. Galiano   +9 more
wiley   +1 more source