Results 91 to 100 of about 3,516,666 (358)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

TNF-α and IFN-γ primed iNOS Gene Expression Dynamics.

, 2016
The model was simulated with TNF-α, IFN-γ, or both TNF-α /IFN-γ for 24 simulation hours to prime the system. The concentrations of iNOS transcription factors, iNOS mRNA, and iNOS protein were used as inputs to the system for an 8-hour addition simulation
Taha Salim (2825270), Elebeoba E. May (2825273), Cheryl L. Sershen (350195)   +2 more
core   +1 more source

Development of monoclonal antibodies for quantification of bovine tumor necrosis factor-α

JDS Communications, 2021
The expression of the proinflammatory cytokine tumor necrosis factor-α (TNF-α) is associated with production losses in dairy cows and is a hallmark of early inflammatory processes. Reliable tools for the detection and quantification of soluble as well as
Anja Sipka, Susanna Babasyan, Sabine Mann, Heather Freer, Suzanne Klaessig, Bettina Wagner   +5 more
doaj   +1 more source

Penurunan Luaran Neurodevelopmental pada Sepsis Neonatal terjadi melalui Peningkatan IL- 6 dan bukan TNF-α

Jurnal Kedokteran Brawijaya, 2015
Bayi yang mengalami gangguan pada masa prenatal, natal dan paska natal mempunyai risiko tinggi untuk mendapatkan hambatan tumbuh kembang secara optimal dibandingkan bayi lainnya. IL-6 dan TNF-α merupakan salah satu sitokin yang diproduksi saat terjadi sepsis dan mempunyai peranan pada perkembangan otak sebagai sinyal proinflamasi.
Rahmawati Aminingrum, Ariani Ariani, M Istiadjid ES   +2 more
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Tumour necrosis factor-α regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-κB and AP-1.

PLoS ONE, 2014
Eosinophils play a central role in asthma. The present study was performed to investigate the effect of tumour necrosis factor-α (TNF-α) on longevity of isolated human eosinophils.
Hannu Kankaanranta, Pinja Ilmarinen, Xianzhi Zhang, Ian M Adcock, Aleksi Lahti, Peter J Barnes, Mark A Giembycz, Mark A Lindsay, Eeva Moilanen   +8 more
doaj   +1 more source

A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-α

European Journal of Medical Research, 2017
BackgroundThis report aims to study the relationship between sarcopenia of elderly in community and inflammatory factors IL-6 and TNF-α.MethodsA total of 441 elders who undertook physical examinations were included into this study.
Ai-Lin Bian, Hui-ying Hu, Yudong Rong, Jian Wang, Jun-Xiong Wang, Xin-Zi Zhou   +5 more
semanticscholar   +1 more source

THE INFLUENCE OF PEPAYA LEAF STEW (CARICA PAPAYA) ON PROSTAGLANDIN (PGF2 α) AND TNF-α LEVELS IN DISMENOREA PATIENTS

Jurnal Kesehatan, 2023
Analysis:The prevalence of dysmenorrhoea in Indonesia is quite high at 64.25%. Several factors are known as a factor in the occurrence of dysmenorrhoea among others is the increased synthesis of Prostaglandins (PGF2α) and Cytokines (TNFαα) as mediators that play an important role besides PGF2α in the inflammatory process.Method:The purpose of this ...
Nisa, Setia, Maifita, Yesi
openaire   +1 more source

The ability of earthworm Lumbricus rubellus extract in slowing down the activation of NFkB and TNF-α in lipopolysaccharide-induced Rattus norvegicus

Bali Medical Journal, 2019
Background: Earthworm (L. rubellus) contains many compounds such as Lumbricin I, G-90 glycoprotein, and polyphenols as antimicrobial, antioxidant, and hepatoprotective toward bacterial infections. Tumor necrosis factor (TNF-α) has been identified as a mediator for necrosis tumor inside animal serum treated by lipopolysaccharide (LPS).
Neiny Prisy Foekh, I Dewa Made Sukrama, Anak Agung Wiradewi Lestari   +2 more
openaire   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source