Results 101 to 110 of about 820,645 (209)

Dipeptidyl peptidase-4 activity might be a link between tumour necrosis factor alpha and insulin resistance in type 1 diabetes [PDF]

, 2016
Tumour necrosis factor alpha (TNF α) leads to β cell damage in type 1 diabetes (T1DM) but also causes insulin resistance (IR). It modulates dipeptidyl peptidase-4 (DPP-4) activity, adipokine linked with both IR and T1DM. We were interested if there is an
Blaslov, Kristina, Duvnjak, Lea, Knežević Ćuća, Jadranka, Nikolac Perković, Matea   +3 more
core   +1 more source

Korelasi Kadar TNF-α dan Skor Psoriasis Area And Severity Index (PASI) pada Pasien Psoriasis [PDF]

, 2011
Correlation of serum TNF-α levels and psoriasis area and severity index (PASI) score in psoriatic patientsBackround: Psoriasis is a chronic inflammatory disease characterized by erythematous scaly patches. Psoriasis affects ±2.5% of world population, and
Budiastuti, A. (Asih)
core  

TNF-α is a potential therapeutic target to overcome sorafenib resistance in hepatocellular carcinomaResearch in context

EBioMedicine, 2019
Background: The role of tumor necrosis factor alpha (TNF-α) in targeted therapy for hepatocellular carcinoma (HCC) remains largely unknown. The current study aimed to clarify the mechanistic effects of targeting TNF-α to overcome sorafenib resistance in ...
Wenliang Tan, Xuan Luo, Wenda Li, Jinyi Zhong, Jun Cao, Sicong Zhu, Xianqing Chen, Rui Zhou, Changzhen Shang, Yajin Chen   +9 more
doaj   +1 more source

LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease [PDF]

, 2015
Lipopolysaccharide (LPS) is currently considered one of the major players in non-alcoholic fatty liver disease (NAFLD) pathogenesis and progression.
Agostinelli, Laura, Alisi, Anna, Bruscalupi, Giovannella, Ceccarelli, Sara, Crudele, Annalisa, Cucchiara, Salvatore, De Stefanis, Cristiano, Furlanello, Cesare, Gnani, Daniela, Mina, Marco, Musso, Giovanni, Nobili, Valerio, Panera, Nadia, Petrini, Stefania, Rychlicki, Chiara, Stronati, Laura, Svegliati Baroni, Gianluca   +16 more
core   +2 more sources

Cocoa polyphenols suppress TNF-α-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells [PDF]

, 2017
Cocoa polyphenols have antioxidant and anti-inflammatory effects. TNF-α is a pro-inflammatory cytokine that has a vital role in the pathogenesis of inflammatory diseases such as cancer and psoriasis.
Jung, Sung Keun, Kang, Nam Joo, Kim, Jong-Eun, Lee, Chang Yong, Lee, Hyong Joo, Lee, Ki Won, Son, Joe Eun   +6 more
core  

Genome engineering of stem cells for autonomously regulated, closed-loop delivery of biologic drugs [PDF]

, 2017
Chronic inflammatory diseases such as arthritis are characterized by dysregulated responses to pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α).
Brunger, Jonathan M, Gersbach, Charles A, Guilak, Farshid, Willard, Vincent P, Zutshi, Ananya   +4 more
core   +3 more sources

TNFα Induces DNA and Histone Hypomethylation and Pulmonary Artery Smooth Muscle Cell Proliferation Partly via Excessive Superoxide Formation

Antioxidants
Objective: The level of tumor necrosis factor-α (TNF-α) is upregulated during the development of pulmonary vascular remodeling and pulmonary hypertension. A hallmark of pulmonary arterial (PA) remodeling is the excessive proliferation of PA smooth muscle
Patrick Crosswhite, Zhongjie Sun
doaj   +1 more source

Forward and Reverse Signaling Mediated by Transmembrane Tumor Necrosis Factor-Alpha and TNF Receptor 2: Potential Roles in an Immunosuppressive Tumor Microenvironment

Frontiers in Immunology, 2017
Tumor necrosis factor-alpha (TNF-α) is a pleiotropic inflammatory cytokine produced mainly by activated macrophages, lymphocytes and other cell types. Two distinct forms of TNF-α have been identified: soluble TNF-α (sTNF-α) and transmembrane TNF-α (mTNF ...
Yang Qu, Yang Qu, Yang Qu, Gang Zhao, Gang Zhao, Gang Zhao, Hui Li, Hui Li, Hui Li   +8 more
doaj   +1 more source

Hubungan kadar TNF-α dengan HOMA-IR pada pasien diabetes mellitus tipe-2 di Rumah Sakit Umum Pusat Haji Adam Malik, Medan, Indonesia

Intisari Sains Medis, 2019
Background: The homeostatic assessment (HOMA) of the first cell-β (B) and insulin (IR) function is used to determine insulin sensitivity and cell-β function of insulin plasma concentrations and fasting glucose. High extracellular glucose levels will trigger an increase in ROS production (which in turn will increase the formation of Reactive Oxygen ...
Poltak Poltak, Santi Syafril, Ratna Akbari Ganie   +2 more
openaire   +2 more sources

Quantitative comparison of the neutralizing capacity, immunogenicity and cross-reactivity of anti-TNF-α biologicals and an Infliximab-biosimilar.

PLoS ONE, 2018
IntroductionTNF-α-neutralizing antibodies, such as infliximab (IFX) and adalimumab (ADA), are effective in the treatment of inflammatory bowel diseases (IBD), but they are expensive and become ineffective when patients develop anti-IFX or anti-ADA ...
D J Buurman, T Blokzijl, E A M Festen, B T Pham, K N Faber, E Brouwer, G Dijkstra   +6 more
doaj   +1 more source