Results 141 to 150 of about 565,658 (299)

The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors

Nature Communications
The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) is synthesized as transmembrane TNF-α (tmTNF-α) where proteolytic processing releases soluble TNF-α (sTNF-α).
Obinna C. Ubah, Eric W. Lake, Kendahl L. Ott, Stella Priyanka, Sasha Celeda, Jayden L. West, Gihan S. Gunaratne, Ke Shi, Nicholas H. Moeller, Andrew J. Porter, Hideki Aihara, David Kosoff, Aaron M. LeBeau, Caroline J. Barelle   +13 more
doaj   +1 more source

PMS13 EXPERIMENTAL STUDY OF TOPICAL TREATMENT OF RHEUMATOID ARTHRITIS WITH TNF-Α ANTAGONIST [PDF]

Value in Health, 2019
openaire   +1 more source

High Level of Tumor Necrosis Factor (TNF)-α is a Risk Factor for Preeclampsia

Indonesian Journal of Obstetrics and Gynecology, 2016
Objective: To define that elevated TNF-α serum level was the risk factor of preeclampsia in pregnancy. Method: This research is a case-control study. From 56 pregnant women, there are 28 women with preeclampsia and the other 28 women with normal pregnancy. Then the serum level of TNF-α was obtained at Prodia’s clinical Laboratory Denpasar.
openaire   +2 more sources

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

TNF-α and IL-10 downregulation and marked oxidative stress in Neuromyelitis Optica [PDF]

, 2009
Giselle Pentón‐Rol, Majel Cervantes‐Llanos, Gregorio Martı́nez-Sánchez, José Antonio Cabrera-Gómez, Carmen Valenzuela‐Silva, Omar Ramírez‐Núñez, Mayté Casanova-Orta, María A. Robinson-Agramonte, Ileana Lopategui‐Cabezas, Pedro López‐Saura   +9 more
openalex   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

High-level TNF-α Secretion and Macrophage Activity with Soluble β-Glucans fromSaccharomyces cerevisiae [PDF]

, 2002
Do‐Youn Lee, In-Hye JI, Hyo-Ihl Chang, Chan‐Wha Kim   +3 more
openalex   +1 more source

Gentamicin‐Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections

Advanced Healthcare Materials, EarlyView.
A bone substitute with gentamicin physically precipitated onto the surface of carbonate apatite exhibits prompt drug release, high bactericidal activity, and osteogenic capacity. Efficient antibacterial activity mitigates early postoperative neutrophil accumulation, the status of which may serve as a potential parameter for evaluating the antibacterial
Linghao Xiao, Gabriela Laranjeira Abe, Jun‐Ichi Sasaki, Haruaki Kitagawa, Ririko Tsuboi, Tomoki Kohno, Satoshi Imazato   +6 more
wiley   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source