Results 61 to 70 of about 1,230,752 (303)

Contribution of Toll-Like Receptors and the NLRP3 Inflammasome in Rheumatoid Arthritis Pathophysiology

open access: yesImmunoTargets and Therapy, 2021
Sarah Unterberger, Kevin A Davies, Srinivasa Bhargav Rambhatla, Sandra Sacre Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton, BN1 9PS, UKCorrespondence: Sandra Sacre Tel +441273 872865Email s.sacre@bsms.ac.ukAbstract ...
Unterberger S   +3 more
doaj  

Immunometabolic changes in macrophages in response to house dust mite extract

open access: yesМедицинская иммунология, 2023
To date, much remains unclear about the pathogenesis of asthma, one of the most common chronic and highly heterogenic diseases of the respiratory system.
T. R. Yurakova   +4 more
doaj   +1 more source

Enhanced release of elastase is not concomitant with increased secretion of granulocyte-activating cytokines in whole blood from patients with sepsis [PDF]

open access: yes, 1994
Die Diskussion am Ende des Artikels wurde gelöscht (§137l UrhG).Background The proteolytic enzyme elastase released by granulocytes (polymorphonuclear leukocytes [PMN]) in high concentrations during sepsis causes degradation of essential plasma proteins,
Ertel, Wolfgang   +6 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Lymphotoxin is an autocrine growth factor for Epstein-Barr virus-infected B cell lines. [PDF]

open access: yes, 1993
Because human lymphotoxin (LT) was originally isolated from a lymphoblastoid cell line, we investigated the role of this molecule in three newly established Epstein-Barr virus (EBV)-infected human B cell lines.
Aggarwal, BB   +8 more
core   +1 more source

Serum cholesterol levels in neutropenic patients with fever [PDF]

open access: yes, 2002
Hypocholesterolemia, which often accompanies infectious diseases has been suggested to serve as a prognostic marker in hospitalized patients. Even though patients with chemotherapyinduced leukopenia are at high risk of infection and mortality, only ...
Alvarez C   +10 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Circulating Levels of Adipokines and TNF in Patients with and without Type 1 Diabetes

open access: yesJournal of the Dow University of Health Sciences, 2013
Objective: The aim of this study was to evaluate circulating levels of adiponectin, resistin, visfatin and TNFin type1 diabetic children and young adolescents.
Anila Jaleel   +3 more
doaj  

Evaluation of inflammatory response in patients undergoing surgical treatment for early and delayed femoral fractures

open access: yesArchives of Medical Science, 2018
Introduction It has been shown that long bone fractures are correlated with the inflammatory response. In the initial injury, surgical reduction and fixation of fractures induce the immunoinflammatory response.
Mehdi Moghtadaei   +4 more
doaj   +1 more source

Regulation of 92-kD gelatinase release in HL-60 leukemia cells [PDF]

open access: yes, 1994
Matrix metalloproteinase 9 (MMP-9), also known as 92-kD type IV collagenase/gelatinase, is believed to play a critical role in tumor invasion and metastasis. Here, we report that MMP-9 was constitutively released from the human promyelocytic cell line HL-
Kolb, H.   +2 more
core  

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