Results 71 to 80 of about 1,230,752 (303)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Expression and DNA methylation of TNF, IFNG and FOXP3 in colorectal cancer and their prognostic significance. [PDF]

, 2014
BACKGROUND: Colorectal cancer (CRC) progression is associated with suppression of host cell-mediated immunity and local immune escape mechanisms. Our aim was to assess the immune function in terms of expression of TNF, IFNG and FOXP3 in CRC. METHODS:
A D Beggs, A Merlo, AG Heriot, AM Wolf, C Evans, C Grunfeld, C Loddenkemper, CF Evans, D Kumar, DJ Needham, E Sato, F Balkwill, G Brandacher, G Galizia, G Pawelec, H Nakayama, IC Talbot, JC Harrison, JD Fontenot, JK Polansky, KE Sullivan, KJ Livak, KL Ling, L Xue, LA Liotta, LM Ebert, M Kanazawa, M Kim, M Morris, M Shibata, N Hiraoka, N Kobayashi, N Watanabe, P Quirke, P Radhakrishnan, P Salama, PJ Coffer, R Somasundaram, RJ O’Hara, S Hinz, S Hori, S K Ganapathi, S Ogino, S V Hodgson, SL Clarke, SM Phillips, T Blankenstein, T Sato, TJ Curiel, TJ Curiel, VC Petersen, W Zou, X Chen   +52 more
core   +2 more sources

Effect of Propolis supplementation on C-reactive protein levels and other inflammatory factors:A systematic review and meta-analysis of randomized controlled trials [PDF]

, 2020
Propolis is a resin-like substance collected by honeybees from certain plants that have been shown to positive effect on inflammatory factors. Therefore, the aim of this study was to systematically review and meta-analyse the effects of Propolis ...
Ali Aldhaleei, Wafa, Bhagavathu, Akshaya Srikanth, Clark, Cain, Karam, Giorgio, Rahmani, Jamal, Rinald, Giulia, Salehisahlabadi, Ammar, Shang, Huaping, Yuan, Qian   +8 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

TNF-a and FGF immunohistochemical expressions and pathological evaluation of the duck's liver lesions in Mosul city [PDF]

Iraqi Journal of Veterinary Sciences
This research focuses on studying liver illnesses in ducks in Mosul city by analyzing the expression of TNF alpha and FGF proteins as indicators of inflammation and abnormal growths in the liver tissues samples were collected from duck liver in Mosul ...
Soadd M. Alhamdani, Ahmed N. Flayyih, Ayman A. Al-Alhially   +2 more
doaj   +1 more source

Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis [PDF]

, 1990
By intrasplenic immunization we raised a rat mAb (mAb V1q; IgG2a, kappa) with a potent neutralizing activity against natural mouse TNF (1 microgram/ml mAb V1q/100 U/ml TNF). mAb V1q was used to study the role of endogenous TNF in experimental peritonitis
Echtenacher, B., Falk, Werner, Krammer, P. H., Männel, D. N.   +3 more
core  

Role of tumour necrosis factor gene polymorphisms (-308 and -238) in breast cancer susceptibility and severity [PDF]

, 2004
Introduction Genetic polymorphisms in the promoter region of the tumour necrosis factor (TNF) gene can regulate gene expression and have been associated with inflammatory and malignant conditions. We have investigated two polymorphisms in the promoter
Azmy, I.A.F., Balasubramanian, S.P., Brown, N.J., Cox, A., Reed, M.W.R., Stephenson, T.J., Wilson, A.G.   +6 more
core   +2 more sources

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation [PDF]

, 2020
Receptor interacting protein kinase 1 (RIPK1) regulates cell death and inflammatory responses downstream of TNFR1 and other receptors, and has been implicated in the pathogenesis of inflammatory and degenerative diseases.
Bertrand, Mathieu, Corona, Teresa, Delanghe, Tom, Kondylis, Vangelis, Krüger, Marcus, Kumari, Snehlata, Laurien, Lucie, Nagata, Masahiro, Pasparakis, Manolis, Schwarzer, Robin, Schünke, Hannah, Wiederstein, Janica L.   +11 more
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

THE GLUTATHIONE SYSTEM IS INVOLVED IN REGULATION OF TUMOR CELLS APOPTOSIS

Бюллетень сибирской медицины, 2014
The research objective is to determine the role of the gluthatione system components in realization of the receptor pathway of Jukart tumor cell apoptosis.Apoptosis realization using FITC-labeled annexin V and propidium iodide as well as the amount of ...
N. V. Ryazantseva, O. L. Nosareva, Ye. A. Stepovaya, Ye. V. Zakirova, A. I. Naumova, O. N. Vesnina, Ye. V. Shakhristova, D. S. Orlov, V. D. Yakushina, V. V. Novitsky   +9 more
doaj   +1 more source