Results 101 to 110 of about 53,707 (250)

A shared mechanism for TNP-ATP recognition by members of the P2X receptor family

Computational and Structural Biotechnology Journal
P2X receptors (P2X1–7) are non-selective cation channels involved in many physiological activities such as synaptic transmission, immunological modulation, and cardiovascular function.
Xiao-Bo Ma, Chen-Xi Yue, Yan Liu, Yang Yang, Jin Wang, Xiao-Na Yang, Li-Dong Huang, Michael X. Zhu, Motoyuki Hattori, Chang-Zhu Li, Ye Yu, Chang-Run Guo   +11 more
doaj   +1 more source

Progesterone receptor (PR) intra‐tumor heterogeneity in premenopausal breast cancer: A secondary analysis of a randomized trial

International Journal of Cancer, Volume 158, Issue 4, Page 1106-1115, 15 February 2026.
What's new? Progesterone receptor (PR) expression in breast cancer is influenced by menopausal status and PR positivity is more common in premenopausal women. The influence of PR intra‐tumor heterogeneity on distant recurrence risk in premenopausal women, however, remains unknown. In this investigation, variations in PR expression within breast tumors,
Oscar Danielsson, Huma Dar, Gizeh Perez‐Tenorio, Anna Nordenskjöld, Christina Yau, Christopher C. Benz, Laura J. Esserman, Bo Nordenskjöld, Olle Stål, Tommy Fornander, Johan Hartman, Nicholas P. Tobin, Annelie Johansson, Linda S. Lindström   +13 more
wiley   +1 more source

Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype

Journal of Experimental Medicine, 1979
An idiotype of the dinitrophenyl-binding myeloma protein MOPC 460 was expressed on a small but significant proportion of anti-TNP antibodies which appeared after in vivo or in vitro immunization of BALB/c mice with three T-independent TNP antigens.
C. Bona, W. Paul
semanticscholar   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, Volume 13, Issue 7, 3 February 2026.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

Age‐Related Increase in Anaphylaxis Severity Is Associated With Enhanced Sensitivity to Allergic Mediators

Allergy, EarlyView.
Daniel Brigger, Melanie Steinmann, Nadine Roos, Pascal Guntern, Oliver M. Würgler, Lukas Michaja Balsiger, Alexander Eggel   +6 more
wiley   +1 more source

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science, Volume 13, Issue 9, 13 February 2026.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
wiley   +1 more source

Revealing Seasonal Patterns and Metabolism of Microbial Plankton in a Productive Coastal Upwelling System

Journal of Geophysical Research: Oceans, Volume 131, Issue 2, February 2026.
Abstract Increasing our knowledge about the structure and metabolism of the microbial plankton community in coastal upwelling systems is essential for efficiently managing the resources of these highly productive ecosystems. Here we explore seasonal variations of this community in the NW Iberian coastal upwelling system by measuring variables informing
María López‐Haslett, María Froján, Belén Arbones, Isabel G. Teixeira, Mariña Amo‐Seco, Carmen G. Castro, Francisco G. Figueiras   +6 more
wiley   +1 more source

Evolution of crystallographic texture and material anisotropy effects resulting from uniaxial deformation for high‐strength steels with high manganese content

Journal of Applied Crystallography, Volume 59, Issue 1, Page 163-178, February 2026.
The present study investigates the deformation behavior of high‐strength steels and the associated evolution of material anisotropy. Particular focus is placed on the impact of crystallographic texture and intergranular strains on how residual stresses can be evaluated using X‐ray diffraction and the associated assessment of weld seams in the ...
Michael Zuern, Morteza Dadkhah, Thomas Nitschke-Pagel, Jens Gibmeier   +3 more
wiley   +1 more source

The Effect of IFN-γ, Alum and Complete Freund Adjuvant on TNP-KLH Induced Ig.G1, IgE and IgG2a Responses in Mice

Mediators of Inflammation, 1994
Adjuvants are considered to play an important role in directing the isotype and amount of antibodies produced upon immunization by conducting the development of either Th-1 or Th-2 cells upon T-cell stimulation.
R. van Ommen, A. E. C. M. Vredendaal, M. de Gooyer, A. van Oudenaren, H. F. J. Savelkoul   +4 more
doaj   +1 more source

Optochemical modulation of corneal cold nerve terminal impulse activity with a photochromic ion channel blocker

British Journal of Pharmacology, Volume 183, Issue 3, Page 545-559, February 2026.
Background and Purpose The functional organization of corneal cold nerve endings, critical structures in maintaining the ocular surface, remains poorly understood. Here, the photoisomerizable small‐molecule diethylamine‐azobenzene‐quaternary ammonium (DENAQ) was used to photomodulate activity of cold‐sensing nerve terminals in control and chronic tear ...
David Ares‐Suárez, Almudena Iñigo‐Portugués, Enrique Velasco, Susana Quirce, Fernando Aleixandre‐Carrera, Ariadna Díaz‐Tahoces, M. Carmen Acosta, Wan‐Chen Lin, Richard H. Kramer, Carlos Belmonte, Juana Gallar, Victor Meseguer   +11 more
wiley   +1 more source