Results 21 to 30 of about 99,677 (264)

First Report of Tocilizumab Use in a Cohort of Latin American Patients Hospitalized for Severe COVID-19 Pneumonia

Frontiers in Medicine, 2020
Introduction/objectives: An interleukin-6 inhibition strategy could be effective in selected COVID-19 patients. The objective is to present our experience of tocilizumab use in patients with severe COVID-19.Methods: Observational retrospective cohort ...
Omar Valenzuela, Omar Valenzuela, Sebastián Ibáñez, Sebastián Ibáñez, M. Cecilia Poli, M. Cecilia Poli, M. Cecilia Poli, Patricia Roessler, Patricia Roessler, Mabel Aylwin, Mabel Aylwin, Gigia Roizen, Gigia Roizen, Mirentxu Iruretagoyena, Mirentxu Iruretagoyena, Vivianne Agar, Vivianne Agar, Javiera Donoso, Javiera Donoso, Margarita Fierro, Margarita Fierro, José Montes, José Montes   +22 more
doaj   +1 more source

Tocilizumab Is Associated with Increased Risk of Fungal Infections among Critically Ill Patients with COVID-19 and Acute Renal Failure: An Observational Cohort Study

Life, 2023
Research Question: Does treatment with tocilizumab increase the risk of a fungal infection in critically ill patients with coronavirus-19? Background: Numerous therapies have been evaluated as possible treatments for coronavirus-2019 caused by severe ...
Barrett J. Burger, Sarenthia M. Epps, Victor M. Cardenas, Rajani Jagana, Nikhil K. Meena, William T. Atchley   +5 more
doaj   +1 more source

Avaliação à medida no Segundo HAREM [PDF]

, 2008
Objectives This study compared the efficacy and safety of subcutaneous (SC) versus intravenous (IV) formulations of tocilizumab in patients with rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs (DMARD).
Bao, Min, Burmester, Gerd R., Cantagrel, Alain, Feldman, Daniel, Hall, Stephen, Leszczynski, Piotr, Lu, Peng, Ludivico, Charles, Mysler, Eduardo F., Rangaraj, Madura J., Roane, Georgia, Rowell, Lucy, Rubbert-Roth, Andrea   +12 more
core   +2 more sources

Health-economic analysis of tocilizumab in patients with rheumatoid arthritis and systemic juvenile arthritis

Качественная клиническая практика, 2020
Rationale. Rheumatoid arthritis (RA) and systemic juvenile arthritis (sJA) are the most frequent rheumatic diseases in adults and adolescents, consequently. Biologics disease modifying antirheumatic drugs (bDMARDs) are eff ective in treatment of RA and s
A. S. Kolbin, A. A. Kurylev, S. A. Mishinova, Yu. E. Balykina, M. A. Proskurin   +4 more
doaj   +1 more source

Single-Cell RNA Sequencing of Tocilizumab-Treated Peripheral Blood Mononuclear Cells as an in vitro Model of Inflammation

Frontiers in Genetics, 2021
COVID-19 has posed a significant threat to global health. Early data has revealed that IL-6, a key regulatory cytokine, plays an important role in the cytokine storm of COVID-19.
Arya Zarinsefat, George Hartoularos, Dmitry Rychkov, Priyanka Rashmi, Sindhu Chandran, Flavio Vincenti, Chun J. Yee, Minnie M. Sarwal   +7 more
doaj   +1 more source

How and why systemic inflammation worsens quality of life in patients with advanced cancer [PDF]

, 2017
Introduction: The presence of an innate host systemic inflammatory response has been reported to be a negative prognostic factor in a wide group of solid tumour types in both the operable and advanced setting, both local and distant.
Dolan, Ross D., Horgan, Paul G., McMillan, Donald C., McSorley, Stephen T., Roxburgh, Campbell S.D.   +4 more
core   +1 more source

Off-label use of tocilizumab to treat non-juvenile idiopathic arthritis in pediatric rheumatic patients: a literature review

Pediatric Rheumatology Online Journal, 2018
Tocilizumab, an anti-interleukin-6 (IL-6) agent, is indicated as a treatment for several autoimmune or inflammatory diseases, including rheumatoid arthritis and juvenile idiopathic arthritis (JIA). IL-6 plays roles in both immune system dysregulation and
Ju-Yang Jung, Moon-Young Kim, Chang-Hee Suh, Hyoun-Ah Kim   +3 more
doaj   +1 more source

Rheumatoid arthritis [PDF]

, 2016
Rheumatoid arthritis is a chronic inflammatory joint disease, which can cause cartilage and bone damage as well as disability. Early diagnosis is key to optimal therapeutic success, particularly in patients with well-characterised risk factors for poor ...
Aletaha, Daniel, McInnes, Iain B., Smolen, Josef S.   +2 more
core   +1 more source

Comparison of the inhibitory effect of tocilizumab and etanercept on the progression of joint erosion in rheumatoid arthritis treatment

Scientific Reports, 2022
We compared the efficacy of tocilizumab and etanercept in inhibiting radiographic progression of joint destruction in rheumatoid arthritis. Overall, 187 patients treated with etanercept or tocilizumab were selected.
Shinya Hayashi, Tsukasa Matsubara, Toshihisa Maeda, Koji Fukuda, Keiko Funahashi, Marowa Hashimoto, Ken Tsumiyama, Tomoyuki Kamenaga, Yoshinori Takashima, Tomoyuki Matsumoto, Shotaro Tachibana, Ryosuke Kuroda   +11 more
doaj   +1 more source

Theoretical impact of insecticide-impregnated school uniforms on dengue incidence in Thai children. [PDF]

, 2013
BACKGROUND: Children carry the main burden of morbidity and mortality caused by dengue. Children spend a considerable amount of their day at school; hence strategies that reduce human-mosquito contact to protect against the day-biting habits of Aedes ...
Amaku, Marcos, Coutinho, Francisco Antonio Bezerra, Kittayapong, Pattamaporn, Massad, Eduardo, Wilder-Smith, Annelies   +4 more
core   +2 more sources