Mutations in the TolC Periplasmic Domain Affect Substrate Specificity of the AcrAB-TolC Pump [PDF]
Frontiers in Molecular Biosciences, 2020 TolC and the other members of the outer membrane factor (OMF) family are outer membrane proteins forming trimeric channels that serve as a conduit for most actively effluxed substrates in Gram-negative bacteria by providing a key component in a multitude
Robert L. Marshall +2 more
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A lipoprotein partner for the Escherichia coli outer membrane protein TolC [PDF]
eLifeThe outer membrane protein TolC from Escherichia coli belongs to an extensive superfamily whose members are found throughout the didermal, Gram-negative bacterial lineages.
Jim Horne +11 more
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Structural mechanisms of pump assembly and drug transport in the AcrAB–TolC efflux system [PDF]
eLifeTripartite multidrug efflux pumps that span the cell envelope are essential for antibiotic resistance in Gram-negative bacteria. Here, we report cryo-EM structures of two endogenous efflux complexes from Escherichia coli: a TolC–YbjP subcomplex at 3.56 Å
Xiaofei Ge, Zhiwei Gu, Jiawei Wang
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Frontiers in Microbiology, 2023 BackgroundS. Typhi is a Gram-negative bacterium that causes typhoid fever in humans. Its virulence depends on the TolC outer membrane pump, which expels toxic compounds and antibiotics.
Eugene Boon Beng Ong, Prabha Balaram
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MicrobiologyOpenEnterobacteriaceae possess eight TolC‐dependent multidrug efflux pumps: AcrAB‐TolC, AcrAD‐TolC, AcrEF‐TolC, MdtEF‐TolC, MdtABC‐TolC, EmrAB‐TolC, EmrYK‐TolC, and MacAB‐TolC, which efflux bile salts, antibiotics, metabolites, or other compounds.
Cristian Ruiz
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In situ structure and assembly of the ABC-type tripartite pump MacAB-TolC [PDF]
Communications BiologyThe MacAB-TolC tripartite efflux pump is widely distributed in Gram-negative bacteria, extruding antibiotics and virulence factors that lead to multidrug resistance and pathogenicity.
Tong Huo +9 more
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Integrated analysis of global regulators and efflux genes associated with antimicrobial resistance reversal in multidrug resistant Klebsiella pneumoniae [PDF]
Scientific ReportsBackground Multidrug-resistant Klebsiella pneumoniae poses a growing clinical challenge due to its ability to evade antibiotic treatment, particularly through the overexpression of efflux systems. Among these, the AcrAB-TolC pump is central to resistance
Ali J. Obaid +2 more
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A requirement of TolC and MDR efflux pumps for acid adaptation and GadAB induction in Escherichia coli. [PDF]
PLoS ONE, 2011 BACKGROUND: The TolC outer membrane channel is a key component of several multidrug resistance (MDR) efflux pumps driven by H(+) transport in Escherichia coli.
Kari N W Deininger +6 more
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Membrane fusion proteins of type I secretion system and tripartite efflux pumps share a binding motif for TolC in gram-negative bacteria. [PDF]
PLoS ONE, 2012 The Hly translocator complex of Escherichia coli catalyzes type I secretion of the toxin hemolysin A (HlyA). In this complex, HlyB is an inner membrane ABC (ATP Binding Cassette)-type transporter, TolC is an outer membrane channel protein, and HlyD is a ...
Minho Lee +5 more
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Effects of TolC on the pathogenicity of porcine extraintestinal pathogenic Escherichia coli
Frontiers in Immunology, 2022 Extraintestinal pathogenic Escherichia coli (ExPEC) is a well-known critical pathogenic zoonosis that causes extraintestinal infections in humans and animals by affecting their immune organs. Recently, research on the outer membrane protein of E.
Jin Hu +8 more
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