Results 121 to 130 of about 9,068 (239)

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Combination of Lenvatinib and Antibiotics: A Potential Approach to Enhance Sensitivity in Differentiated Thyroid Cancer

International Journal of Cancer, EarlyView.
Although lenvatinib is the current first‐line therapy for radioiodine‐refractory differentiated thyroid carcinoma, its use is limited by severe side effects and reduced sensitivity. Here, the authors assessed the potential of sensitizing differentiated thyroid carcinoma tumor cells with limited lenvatinib responsiveness through the administration of ...
Celina Ablinger, Petra Huber‐Cantonati, Daniela D. Weber, Sarah Pichler, Georg Schischkow, Marta Garcia‐Miralles, Christian Pirich, Gundula Rendl, Teresa Kiener, Thomas Felder, Martin Geroldinger, Robert Terkola, Barbara Kofler, Johanna Pachmayr   +13 more
wiley   +1 more source

Assessment of Vitamin E Intake in Relation to Tolerable Upper Intake Levels [PDF]

European Journal of Nutrition & Food Safety, 2018
Margaretha Haugen, Inger Therese L. Lillegaard, Livar Frøyland, Sigrun Henjum, Kristin Holvik, Martinus Løvik, Bjørn Steen Skålhegg, Tonje Holte Stea, Tor A. Strand   +8 more
openaire   +1 more source

The TRPM2–PARP‐1 Axis Involvement in Bisphenol A and Nonylphenol‐Induced Ferroptosis in Trigeminal Ganglion Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Environmental contaminants like bisphenol A (BPA) and nonylphenol (NP) are recognized neurotoxicants; however, the molecular mechanisms underlying their impact on sensory ganglia, specifically the trigeminal ganglion (TG), remain critically underexplored.
Betül Yazğan, Musa Tatar, Yener Yazğan, Kıymet Kübra Tüfekci   +3 more
wiley   +1 more source

Contribution of fortified foods and dietary supplements to total nutrient intakes and their adequacy in Japanese adults

BMC Nutrition
Background This study examined how fortified foods and dietary supplements contributed to total nutrient intakes and their adequacy in Japanese adults. Methods Nutrient intake was estimated from 4-day dietary records of 392 adults (20–69 years) in total ...
Minami Sugimoto, Keiko Asakura, Nana Shinozaki, Kentaro Murakami, Shizuko Masayasu, Satoshi Sasaki   +5 more
doaj   +1 more source

Derivation of tolerable upper intake levels of nutrients [PDF]

The American Journal of Clinical Nutrition, 2001
openaire   +1 more source

Protective Effects of Imeglimin Against Oxaliplatin‐Induced Peripheral Neurotoxicity: Evidence From In Vitro and In Vivo Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Oxaliplatin is a platinum‐based anticancer agent widely used for gastrointestinal malignancies; however, it is known to cause dose‐dependent peripheral neuropathy (OIPN), a characteristic adverse effect. OIPN results in a reduced quality of life and often necessitates dose reduction or discontinuation of oxaliplatin; however, effective ...
Yusuke Koura, Kano Kinjo, Keisuke Mine, Yusuke Mori, Mami Ueda, Risa Kaneko, Yuna Kamiya, Taiga Sonoda, Haruka Mimata, Shunsuke Fujita, Takehiro Kawashiri, Daisuke Kobayashi   +11 more
wiley   +1 more source

Utilisation of Objective and Subjective Image Quality Metrics to Guide Optimal Contrast Volumes for Abdominal CT

Journal of Medical Radiation Sciences, EarlyView.
Determining the appropriate volume of iodinated contrast media (ICM) for portal venous phase abdominal CT is challenging. Objective image quality assessment demonstrates weight‐based volume dosing reduces the dependence of enhancement on patient size, compared to fixed volume.
Deborah Carrick, Mitchell Ashton, Joshua Bognar, Natalia Diaz, James Rogers, Daniel Serra, Daniel Schick   +6 more
wiley   +1 more source

Comprehensive elucidation of volatile, phenolic, and organic acid profiles in Turkish mallow (Malva sylvestris L.) petal herbal tea: impact of diverse brewing conditions

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Mallow (Malva sylvestris L.) petals are traditionally consumed as herbal tea across the Mediterranean for their soothing and anti‐inflammatory properties; however, scientific characterization of this consumption‐relevant matrix under realistic brewing conditions remains scarce.
Armin Amanpour, Ali Tekin, Ali Adnan Hayaloglu   +2 more
wiley   +1 more source

Assessment of Iron Intake in Relation to Tolerable Upper Intake Levels

European Journal of Nutrition & Food Safety, 2018
Tor A. Strand, Inger Therese L. Lillegaard, Livar Frøyland, Margaretha Haugen, Sigrun Henjum, Kristin Holvik, Martinus Løvik, Bjørn Steen Skålhegg, Tonje Holte Stea, Per Ole Iversen   +9 more
openaire   +1 more source