Results 31 to 40 of about 24,877 (266)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Financial risk tolerance within couples of retail bank clients

International Review of Economics & Finance
This paper examines gender differences in spouses’ financial risk tolerance in a large sample of 10,231 couples of retail bank clients. Our measure of risk tolerance is self-assessed at the bank, in the presence of a financial advisor, through a ...
Marie-Hélène Broihanne, Hava Orkut
doaj   +1 more source

Heterogeneous Map Merging: State of the Art

Robotics, 2019
Multi-robot mapping and environment modeling have several advantages that makeit an attractive alternative to the mapping with a single robot: faster exploration, higherfault tolerance, richer data due to different sensors being used by different systems.
Ilze Andersone
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Societal Perceptions Toward Income Inequality During the Process of Economic Development: Evidence from International Panel Data

Asian Development Review
While economic inequality has gained prominence in the contemporary development debate, the reasons why the degree of tolerance for inequality varies among countries remain an unresolved issue. This knowledge gap has resulted in excessive policy emphasis
WANNAPHONG DURONGKAVEROJ
doaj   +1 more source

Evaluation of Job-Mix Formula Tolerances as Related to Asphalt Mixtures Properties

Journal of Engineering, 2018
The current Iraqi standard specifications for roads and bridges allowed the prepared Job-Mix Formula for asphalt mixtures to witness some tolerances with regard to the following: coarse aggregate gradation by ± 6.0 %, fine aggregate gradation by ± 4.0 %,
Mohammed Qadir Ismael, Reem Fouad Ahmed Al-Harjan   +1 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Conflicting plant responses to silver nanoparticles including specific and non-specific response, tolerance mechanism and positive effect

Green Chemistry Letters and Reviews
In this review, we summarize the basic responses of plants to silver nanoparticles. These have been divided into non-specific (stress response to reactive oxygen species, plant-dependent factors, concentration) and specific responses (AgNPs form, size ...
Gabriela Mikesková, Jana Klepáčová, Emilie Macková, Jana Seidlerová   +3 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source