Results 121 to 130 of about 4,982,676 (293)

The effect of manipulating apoptotic cell uptake on their immunogenicity [PDF]

, 2009
Failure of the immune system to differentiate between apoptotic tumour cells and cells rendered apoptotic as part of homeostasis prevents a successful response being mounted against tumours.
Attfield, Kathrine Elizabeth
core   +1 more source

Expression of tolerogenic potential-representing markers on clinical-grade therapeutic dendritic cell-based cancer vaccines

Acta Medica Lituanica, 2014
Background. Currently a particular interest is given to specific active cancer immunotherapy (therapeutic cancer vaccination) strategies such as treatment with specially “educated” autologous dendritic cells (DCs).
Neringa T. Dobrovolskienė, Marius M. Strioga, Regina Liudkevičienė, Tadas Petraitis, Adas Darinskas, Vita Pašukonienė, Živilė Gudlevičienė   +6 more
doaj   +1 more source

Maternal Perinatal Gut Microbiome Is Shaped by Traditional Farming Lifestyle and Associated With Early Childhood Atopic Disease

Allergy, EarlyView.
We assessed whether the maternal perinatal gut microbiome and serum SCFA and cord blood SCFA differ between traditional farming and urban dyads. Women following a farming lifestyle had increased microbial diversity, several differentially abundant bacterial species and functional pathways, and increased circulating SCFA. Overall maternal gut microbiome
Erin C. Davis, Courtney M. Jackson, Nichole S. Diaz, Jazmine Susana, Ashley Nelson, Richard Insel, Antti E. Seppo, Kirsi M. Järvinen   +7 more
wiley   +1 more source

Protocol of generation of tolerogenic dendritic cells affects their transcriptional and metabolic profiles leading to specific tolerogenic functions

International audienceCell therapy is a promising approach for inducing tolerance and thus reducing the use of immunosuppressive drugs in several immune-mediated conditions.
Chiffoleau, Elise, Raux, Axel, Moreau, Aurélie, de Sio, Francesca Santoni, Suuring, Maaike, Delhaye, Thomas, Rondeau, David, Gregori, Silvia, Royer, Anne-Lise, Cloteau, Chloé, Lavercan, Denisia, Croyal, Mikaël, Amodio, Giada, Rouel, Mathieu   +13 more
core   +1 more source

Cell technologies in the treatment of rheumatic diseases

Научно-практическая ревматология, 2019
Rheumatic diseases are caused by chronic autoimmune processes that require long-term therapy, which leads to the formation of resistance to the drugs used. The search for new approaches to their treatment in recent years has been enriched with the use of
N. F. Soroka, M. P. Potapnev, N. A. Martusevich   +2 more
doaj   +1 more source

The External Exposome and Food Allergy: How Environmental Exposures Shape Disease Risk

Allergy, EarlyView.
ABSTRACT IgE‐mediated food allergy is a global health issue with rising prevalence that cannot be explained by genetic change alone, strongly suggesting that environmental exposures are a key driver. The external exposome encompasses several exposures that influence the developing immune system and modify food allergy risk.
Johanna M. Smeekens, Helen A. Brough, Kirsi M. Järvinen, Sophie Troyer, Michael D. Kulis, Timothy P. Moran   +5 more
wiley   +1 more source

Tumor antigen cross-presentation and the dendritic cell: Where it all begins? [PDF]

, 2010
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hosts ...
McDonnell, A.M., Robinson, B.W.S., Currie, A.J.   +2 more
core  

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development [PDF]

, 2011
Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show
Ishimaru, N., Hollander, G. A., Naozumi Ishimaru, Hayashi, Y., Rene de Waal Malefyt, Nitta, T., Yu Lei, Jeker, LT, Lei, Y., Jeker, L. T., Lei, Y, Georg A. Holländer, Ishimaru, N, Holländer, GA, Bösl, MR, Bosl, M. R., Yoshio Hayashi, Yousuke Takahama, Takahama, Y., Malefyt, RW, Michael R. Bösl, Lukas T. Jeker, Takeshi Nitta, Takahama, Y, Nagasawa, T., Nitta, T, Nagasawa, T, Izumi Ohigashi, Ripen, A. M., Hayashi, Y, Ohigashi, I., Malefyt, R. D., Takashi Nagasawa, Malefyt Rde, W., Ohigashi, I, Ripen, AM, Adiratna Mat Ripen   +36 more
core   +1 more source

B lymphocytes can be activated to act as antigen presenting cells to promote anti-tumor responses.

PLoS ONE, 2018
Immune evasion by tumors includes several different mechanisms, including the inefficiency of antigen presenting cells (APCs) to trigger anti-tumor T cell responses.
Renata Ariza Marques Rossetti, Noely Paula Cristina Lorenzi, Kaori Yokochi, Maria Beatriz Sartor de Faria Rosa, Luciana Benevides, Paulo Francisco Ramos Margarido, Edmund Chada Baracat, Jesus Paula Carvalho, Luisa Lina Villa, Ana Paula Lepique   +9 more
doaj   +1 more source

IgE‐Binding Bacterial Components Not Yet Documented in the Allergen Databases and Their Allergenic Mechanisms: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE‐binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO ...
Uta Jappe, Marua Abu Risha, Ioana Agache, Claus Bachert, Barbara Bröker, Riccardo Castagnoli, Gabriele Gadermaier, Richard E. Goodman, Amir Guemari, Christiane Hilger, Alain Jacquet, Sabine Kespohl, Ludger Klimek, Annette Kuehn, Jonas Lidholm, Vera Mahler, Markus Ollert, Thomas A. Platts‐Mills, Monika Raulf, Peter Schmid‐Grendelmeier, Frieder Schmiedeke, Marianne van Hage, Joana Vitte, Josefina Zakzuk, Anna Pomés   +24 more
wiley   +1 more source