Results 111 to 120 of about 4,982,676 (293)

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Mechanisms regulating autoreactive T cell responses in inflammatory heart disease [PDF]

, 2008
Molecular self-assembly, as a most studied case of self-assembly, is one of the few practical strategies for making ensembles of nano- and micro structures. As an essential aspect of the “bottom-up” approach, it is attractive for both scientific research
Valaperti, Alan
core   +1 more source

Polypropylene Nanoplastic Exposure to Respiratory Epithelial Barrier‐On‐Chip and Interfacial Interactions With Human Serum Albumin

Allergy, EarlyView.
Exposure to 305 nm PP NPs significantly disrupts the airway barrier‐on‐chip, reducing TEER, suppressing ZO‐1/ACE2 expression, and triggering ROS‐mediated apoptosis. In biological media, PP NPs exhibit a biphasic adsorption pattern, leading to the formation of a protein corona that increases their size to 364 nm.
Omur Sert, Eyup Bilgi, Reyhan Coban, Pelin Saglam‐Metiner, Basar Dogan, Zeynep Imir‐Tekneci, Suleyman Selim Cinaroglu, Ozlem Goksel, Ceyda Oksel Karakus, Ozlem Yesil‐Celiktas   +9 more
wiley   +1 more source

Identification of genetic loci in Lactobacillus plantarum that modulate the immune response of dendritic cells using comparative genome hybridization [PDF]

, 2010
Contains fulltext : 88219.pdf (Publisher’s version ) (Open Access)BACKGROUND: Probiotics can be used to stimulate or regulate epithelial and immune cells of the intestinal mucosa and generate beneficial mucosal immunomodulatory effects.
Kleerebezem, M., Vos, P., de, Bilsen, J., van Bilsen Jolanda, Meijerink Marjolein, Savelkoul, H.F.J., Bron, P.A., Savelkoul Huub F., Bilsen, J.G.P.M., van, Huub F. Savelkoul, Wells Jerry M., Vos, P., Marjolein Meijerink, Bilsen, J. van, Jolanda van Bilsen, Bron, Peter A., Wells, J., Savelkoul, Huub F., de Vos Paul, Huub F Savelkoul, Saskia van Hemert, Vos, P. de, Michiel Wels, van Hemert Saskia, Meijerink, M., Jerry M Wells, Kleerebeezem, M., van Bilsen, Jolanda, Wels, Michiel, Kleerebezem, Michiel, Paul de Vos, Michiel Kleerebezem, Kleerebezem Michiel, Peter A. Bron, Taverne, Nico, Taverne Nico, Taverne, N., van Bilsen, J.G.P.M., van Hemert, Saskia, de Vos, Paul, Bron Peter A., Peter A Bron, de Vos, Paul; id_orcid, Wells, J.M., Savelkoul, H.F., van Hemert, S., de Vos, P., Wels Michiel, Nico Taverne, Hemert, S. van, Hemert, S., van, Wels, M., Wells, Jerry M., Jerry M. Wells, Wels, M.W.W., Sanders, M.W.W., Meijerink, Marjolein   +56 more
core   +4 more sources

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

Allergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie‐Charlotte Brüggen   +11 more
wiley   +1 more source

Induction of Tolerogenic Dendritic Cells by a Noncoding Oligonucleotide

European Journal of Immunology
ABSTRACT Tolerogenic dendritic cells (tolDCs) that dampen T cell responses can be induced from blood monocytes in vitro using factors such as Vitamin D3 (VitD), dexamethasone, IL‐10, or rapamycin. However, challenges remain in obtaining robust and efficient generation of cell therapy‐based tolDCs without ...
Kamal, Kahkashan, Trumbo, James, Richardsdotter‐Andersson, Elina, Wahren‐Herlenius, Marie, Spetz, Anna‐Lena   +4 more
openaire   +2 more sources

Rapid Downregulation of DAB2 by Toll-Like Receptor Activation Contributes to a Pro-Inflammatory Switch in Activated Dendritic Cells

Frontiers in Immunology, 2019
Dendritic cells (DCs) are pivotal in regulating tolerogenic as well as immunogenic responses against microorganisms by directing both the innate and adaptive immune response.
Vanessa Figliuolo da Paz, Deepa R. Jamwal, Michael Gurney, Monica Midura-Kiela, Christy A. Harrison, Christopher Cox, Jean M. Wilson, Fayez K. Ghishan, Pawel R. Kiela, Pawel R. Kiela   +9 more
doaj   +1 more source

Preventive Application of House Dust Mite‐Sublingual Immunotherapy Induces Blocking Antibodies in Sensitized Preschool Children

Allergy, EarlyView.
HDM‐pSLIT induced IgG, IgG1, and IgG4 specific to major HDM allergens in sensitized non‐allergic preschool children without increasing HDM‐sIgE. It blunted the development of new sensitizations and reduced HDM reactivity in skin and basophils. HDM‐pSLIT treated children displayed a blocking effect on HDM‐induced basophil activation.
Varsha Dwivedi, Klara Schmidthaler, Hilal Demir, Justyna Sieber, René Gaupmann, Livia Mia Gona‐Höpler, Christina Bannert, Saskia Gruber, Eleonora Dehlink, Thomas Eiwegger, Alexandra Graf, Barbara Bohle, Zsolt Szépfalusi   +12 more
wiley   +1 more source

The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance

Clinical and Developmental Immunology, 2011
Tumor cells commonly escape from elimination by innate and adaptive immune responses using multiple strategies among which is the active suppression of effector immune cells.
Nona Janikashvili, Bernard Bonnotte, Emmanuel Katsanis, Nicolas Larmonier   +3 more
doaj   +1 more source

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source