Results 91 to 100 of about 4,498,564 (240)

Regulatory dendritic cells for immunotherapy in immunologic diseases

Frontiers in Immunology, 2014
We recognize well the abilities of dendritic cells to activate effector T cell responses to an array of antigens and we think of these cells in this context as pre-eminent antigen presenting cells, but dendritic cells are also critical to the induction ...
John Robert Gordon, Yanna eMa, Laura eChurchman, Sara Alicia Gordon, Wojciech eDawicki   +4 more
doaj   +1 more source

Tolerogenic dendritic cells as a therapy for treating lupus

Clinical Immunology, 2013
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that is characterized by the over production of auto-antibodies against nuclear components. Thus, SLE patients have increased morbidity and, mortality compared to healthy individuals. Available therapies are not curative and are associated with unwanted adverse effects. During the last
Llanos, Carolina, Pablo Mackern-Oberti, Juan, Vega, Fabian, Jacobelli, Sergio H., Kalergis, Alexis M.   +4 more
openaire   +19 more sources

Autoreactivity Versus Autoimmunity: Characteristics of Autoantigen‐Specific CD4 T Cells in Rheumatoid Arthritis and Health

Arthritis &Rheumatology, EarlyView.
Objective CD4 T cells specific for citrullinated (cit) peptides are key players in rheumatoid arthritis (RA) immunopathogenesis. Characterizing these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next ...
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source

Tolerance through Education: How Tolerogenic Dendritic Cells Shape Immunity

Frontiers in Immunology, 2017
Dendritic cells (DCs) are central players in the initiation and control of responses, regulating the balance between tolerance and immunity. Tolerogenic DCs are essential in the maintenance of central and peripheral tolerance by induction of clonal T ...
Matthias P. Domogalla, Matthias P. Domogalla, Patricia V. Rostan, Patricia V. Rostan, Verena K. Raker, Verena K. Raker, Kerstin Steinbrink, Kerstin Steinbrink   +7 more
doaj   +1 more source

Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells. [PDF]

PLoS Pathogens, 2018
Following repeated encounters with adenoviruses most of us develop robust humoral and cellular immune responses that are thought to act together to combat ongoing and subsequent infections.
Thi Thu Phuong Tran, Karsten Eichholz, Patrizia Amelio, Crystal Moyer, Glen R Nemerow, Matthieu Perreau, Franck J D Mennechet, Eric J Kremer   +7 more
doaj   +1 more source

Role of regulatory T cells in immune tolerance [PDF]

, 2009
In this present work, we investigated the role of dendritic cells (DC) and regulatory T cells (Treg) in immune tolerance as well as their potential in the treatment of autoimmune or graft versus host (GvH) diseases.
Swee, Lee Kim
core   +1 more source

Early‐stage health technology assessment of a curative gene therapy for multiple sclerosis

British Journal of Clinical Pharmacology, EarlyView.
Aims Multiple sclerosis (MS) is associated with significant early morbidity, reduced life expectancy and substantial healthcare and societal costs. The primary objective of this study is to assess the early cost‐effectiveness potential of a novel gene therapy, IMMUTOL, for MS compared with current high‐efficacy treatment sequences.
Attila Imre, Balázs Nagy, Rok Hren
wiley   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Nanoparticles loaded with IL-2 and TGF-β promote transplantation tolerance to alloantigen

Frontiers in Immunology
We have previously reported that nanoparticles (NPs) loaded with IL-2 and TGF-β and targeted to T cells induced polyclonal T regulatory cells (Tregs) that protected mice from graft-versus-host disease (GvHD).
David A. Horwitz, David A. Horwitz, Ju Hua Wang, Dongin Kim, Chang Kang, Katja Brion, Sean Bickerton, Antonio La Cava, Antonio La Cava   +8 more
doaj   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source