Results 71 to 80 of about 4,498,564 (240)
Liposomes loaded with vitamin D3 induce regulatory circuits in human dendritic cells
Frontiers in Immunology, 2023 IntroductionNanomedicine provides a promising platform for manipulating dendritic cells (DCs) and the ensuing adaptive immune response. For the induction of regulatory responses, DCs can be targeted in vivo with nanoparticles incorporating tolerogenic ...
Noémi Anna Nagy +12 more
doaj +1 more source
Studies of clinically applicable human tolerogenic dendritic cells and PD-L2 genetic modification of human islet allograft to promote graft tolerance. [PDF]
, 2011 Islet transplantation is a developing therapy for type 1 diabetic patients (T1D), which has been limited by problems associated with hypoxia, poor revascularisation and allograft rejection.
Rojas-Canales, Darling
core
Semen Promotes the Differentiation of Tolerogenic Dendritic Cells [PDF]
The Journal of Immunology, 2012 Abstract Seminal plasma is not just a carrier for spermatozoa. It contains high concentrations of cytokines, chemokines, and other biological compounds that are able to exert potent effects on the immune system of the receptive partner.
Federico, Remes Lenicov +12 more
openaire +2 more sources
Advanced Science, EarlyView.Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang +10 more
wiley +1 more source
Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy
Advanced Science, EarlyView.A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu +15 more
wiley +1 more source
Mechanisms and consequences of reduced dendritic growth of cerebellar Purkinje cells [PDF]
, 2012 The cerebellum is a brain region crucial for coordination and motor learning. Being the principal output cell of the cerebellar cortex, Purkinje cell loss and degeneration play an important role in many cerebellar diseases.
Gugger, Olivia S.
core +1 more source
Advanced Science, EarlyView.A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu +13 more
wiley +1 more source
Acta Medica Lituanica, 2014 Background. Currently a particular interest is given to specific active cancer immunotherapy (therapeutic cancer vaccination) strategies such as treatment with specially “educated” autologous dendritic cells (DCs).
Neringa T. Dobrovolskienė +6 more
doaj +1 more source
Postnatal development of dendritic calcium signaling in rat hippocampal pyramidal cells [PDF]
, 2013 In CA1 pyramidal neurons, dendritic calcium transients in stratum radiatum were evoked in acute slices via backpropagating action potentials using patch clamp recordings.
Pohle, Jörg
core +1 more source
Advanced Science, EarlyView.An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu +10 more
wiley +1 more source