Results 51 to 60 of about 24,183 (235)

The Long Noncoding RNA MALAT1 Induces Tolerogenic Dendritic Cells and Regulatory T Cells via miR155/Dendritic Cell-Specific Intercellular Adhesion Molecule-3 Grabbing Nonintegrin/IL10 Axis

Frontiers in Immunology, 2018
By shaping T cell immunity, tolerogenic dendritic cells (tDCs) play critical roles in the induction of immune tolerance after transplantation. However, the role of long noncoding RNAs (lncRNAs) in the function and immune tolerance of dendritic cells (DCs)
Jian Wu, Jian Wu, Hanlu Zhang, Hanlu Zhang, Yang Zheng, Yang Zheng, Xiangyuan Jin, Mingyang Liu, Mingyang Liu, Shuang Li, Shuang Li, Qi Zhao, Qi Zhao, Xianglan Liu, Xianglan Liu, Yongshun Wang, Ming Shi, Shengnan Zhang, Shengnan Zhang, Jinwei Tian, Jinwei Tian, Yong Sun, Yong Sun, Maomao Zhang, Maomao Zhang, Bo Yu, Bo Yu   +26 more
doaj   +1 more source

Antigen-specific tolerogenic dendritic cells ameliorate the severity of murine collagen-induced arthritis. [PDF]

PLoS ONE, 2015
Dendritic cells (DCs) play important roles in initiation of the pathogenic processes of autoimmune disorders, such as rheumatoid arthritis (RA). Tolerogenic dendritic cells (tolDCs) are generated from naïve DCs and induce T cell tolerance; thus, they ...
Bin Ning, Jianlu Wei, Aijun Zhang, Weiming Gong, Jinqiu Fu, Tanghong Jia, Shang-You Yang   +6 more
doaj   +1 more source

Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications [PDF]

Immune Network, 2016
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that bridge innate and adaptive immune responses, thereby leading to immune activation. DCs have been known to recognize pathogen-associated molecular patterns such as lipopolysaccharides (LPS) and nucleic acids via their pattern recognition receptors, which trigger signaling of ...
Yoo, Seungbo, Ha, Sang-Jun
openaire   +2 more sources

Identification of genetic loci in Lactobacillus plantarum that modulate the immune response of dendritic cells using comparative genome hybridization [PDF]

, 2010
Contains fulltext : 88219.pdf (Publisher’s version ) (Open Access)BACKGROUND: Probiotics can be used to stimulate or regulate epithelial and immune cells of the intestinal mucosa and generate beneficial mucosal immunomodulatory effects.
Kleerebezem, M., Vos, P., de, Bilsen, J., van Bilsen Jolanda, Meijerink Marjolein, Savelkoul, H.F.J., Bron, P.A., Savelkoul Huub F., Bilsen, J.G.P.M., van, Huub F. Savelkoul, Wells Jerry M., Vos, P., Marjolein Meijerink, Bilsen, J. van, Jolanda van Bilsen, Bron, Peter A., Wells, J., Savelkoul, Huub F., de Vos Paul, Huub F Savelkoul, Saskia van Hemert, Vos, P. de, Michiel Wels, van Hemert Saskia, Meijerink, M., Jerry M Wells, Kleerebeezem, M., van Bilsen, Jolanda, Wels, Michiel, Kleerebezem, Michiel, Paul de Vos, Michiel Kleerebezem, Kleerebezem Michiel, Peter A. Bron, Taverne, Nico, Taverne Nico, Taverne, N., van Bilsen, J.G.P.M., van Hemert, Saskia, de Vos, Paul, Bron Peter A., Peter A Bron, de Vos, Paul; id_orcid, Wells, J.M., Savelkoul, H.F., van Hemert, S., de Vos, P., Wels Michiel, Nico Taverne, Hemert, S. van, Hemert, S., van, Wels, M., Wells, Jerry M., Jerry M. Wells, Wels, M.W.W., Sanders, M.W.W., Meijerink, Marjolein   +56 more
core   +1 more source

Tolerogenic effect of mouse fibroblasts on dendritic cells [PDF]

Immunology, 2016
SummaryThere is controversy about the immunomodulatory effect of fibroblasts on dendritic cells (DCs). To clarify this issue, in this study, we have evaluated different features of fibroblast‐primed DCs including their ability to express co‐inhibitory and co‐stimulatory molecules, pro‐inflammatory and anti‐inflammatory cytokines and their ability to ...
Mohsen, Khosravi-Maharlooei, MohammadReza, Pakyari, Reza B, Jalili, Sanam, Salimi-Elizei, Jacqueline C Y, Lai, Malihesadat, Poormasjedi-Meibod, Ruhangiz T, Kilani, Jan, Dutz, Aziz, Ghahary   +8 more
openaire   +2 more sources

Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells

Mediators of Inflammation, 2016
Dendritic cells present in the digestive tract are constantly exposed to environmental antigens, commensal flora, and invading pathogens. Under steady-state conditions, these cells have high tolerogenic potential, triggering differentiation of regulatory
Julio Aliberti
doaj   +1 more source

Tolerogenic function of Blimp-1 in dendritic cells [PDF]

Journal of Experimental Medicine, 2011
Blimp-1 has been identified as a key regulator of plasma cell differentiation in B cells and effector/memory function in T cells. We demonstrate that Blimp-1 in dendritic cells (DCs) is required to maintain immune tolerance in female but not male mice. Female mice lacking Blimp-1 expression in DCs (DCBlimp-1ko) or haploid for Blimp-1 expression exhibit
Kim, Sun Jung, Zou, Yong Rui, Goldstein, Jordan, Reizis, Boris, Diamond, Betty   +4 more
openaire   +3 more sources

Functional Ambivalence of Dendritic Cells: Tolerogenicity and Immunogenicity

International Journal of Molecular Sciences, 2021
Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) and inducers of T cell-mediated immunity. Although DCs play a central role in promoting adaptive immune responses against growing tumors, they also establish and maintain peripheral tolerance.
Ji-Hee Nam, Jun-Ho Lee, So-Yeon Choi, Nam-Chul Jung, Jie-Young Song, Han-Geuk Seo, Dae-Seog Lim   +6 more
openaire   +2 more sources

The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection.

, 2009
BACKGROUND: Leukocyte Ig-like receptors (LILR) are a family of innate immune receptors with immunomodulatory functions. High-level expression of the receptors LILRB2 (ILT4) and LILRB4 (ILT3) is a feature of tolerogenic antigen presenting cells and has ...
Lapaque Nicolas, Brown Damien P, Buerki, RA, Allen, RL, Brown, DP, Trowsdale John, Allen Rachel L, Jones Des C, Anderson, KJ, Buerki Robin A, Jones, DC, Lapaque, N, Trowsdale, J, Anderson Katie J   +13 more
core   +1 more source

Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans

Topics in Cognitive Science, EarlyView., 2023
Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica, Michael Levin, Fernando E. Rosas, Karl Friston   +3 more
wiley   +1 more source