Results 51 to 60 of about 4,498,564 (240)

Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells

Mediators of Inflammation, 2016
Dendritic cells present in the digestive tract are constantly exposed to environmental antigens, commensal flora, and invading pathogens. Under steady-state conditions, these cells have high tolerogenic potential, triggering differentiation of regulatory
Julio Aliberti
doaj   +1 more source

Inhibition of phosphatidylserine recognition heightens the immunogenicity of irradiated lymphoma cells in vivo [PDF]

, 2004
Strategies to enhance the immunogenicity of tumors are urgently needed. Although vaccination with irradiated dying lymphoma cells recruits a tumor-specific immune response, its efficiency as immunogen is poor.
Zimmermann, VS, Voll, Reinhard E., Turnay, Javier, Manfredi, Angelo A., Turnay, J, Dumitriu, IE, Voll, RE, Zimmermann, Valérie S, Angelo A. Manfredi, Bertling, Wolf, Rovere-Querini, P, Kalden, JR, Udo S. Gaipl, Herrmann, M, Attilio Bondanza, Gaipl, Udo S, Wolf Bertling, Bertling, W, Patrizia Rovere-Querini, Ingrid E. Dumitriu, Bondanza, Attilio, Stach, Christian M., Pöschl, E, Stach, Christian M, Gaipl, US, Javier Turnay, Herrmann, Martin, Martin Herrmann, Dumitriu, Ingrid E., Rovere-Querini, Patrizia, Christian M. Stach, Manfredi, Angelo A, Kalden, Joachim R, Valérie S. Zimmermann, Pöschl, Ernst, Stach, CM, Dumitriu, Ingrid E; id_orcid, Gaipl, Udo S., Joachim R. Kalden, Bondanza, A, Zimmermann, Valérie S., Voll, Reinhard E, Kalden, Joachim R., Reinhard E. Voll, Manfredi, AA, Ernst Pöschl, Dumitriu IE, ROVERE QUERINI , PATRIZIA, Kalden JR, Bertling W, Turnay J, BONDANZA , ATTILIO, Herrmann M., Poschl E, Zimmermann VS, Gaipl US, Stach CM, MANFREDI , ANGELO ANDREA M. A., Voll RE   +58 more
core   +1 more source

Tolerogenic effect of mouse fibroblasts on dendritic cells [PDF]

Immunology, 2016
SummaryThere is controversy about the immunomodulatory effect of fibroblasts on dendritic cells (DCs). To clarify this issue, in this study, we have evaluated different features of fibroblast‐primed DCs including their ability to express co‐inhibitory and co‐stimulatory molecules, pro‐inflammatory and anti‐inflammatory cytokines and their ability to ...
Mohsen, Khosravi-Maharlooei, MohammadReza, Pakyari, Reza B, Jalili, Sanam, Salimi-Elizei, Jacqueline C Y, Lai, Malihesadat, Poormasjedi-Meibod, Ruhangiz T, Kilani, Jan, Dutz, Aziz, Ghahary   +8 more
openaire   +2 more sources

Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage

Journal of Immunology Research, 2015
Dendritic cells (DCs), the most important professional antigen-presenting cells (APC), play crucial role in both immunity and tolerance. It is well known that DCs are able to mount immune responses against foreign antigens and simultaneously tolerate ...
Priscila de Matos Silva, Julia Bier, Lisiery Negrini Paiatto, Cassia Galdino Albuquerque, Caique Lopes Souza, Luis Gustavo Romani Fernandes, Wirla Maria da Silva Cunha Tamashiro, Patricia Ucelli Simioni   +7 more
doaj   +1 more source

Molecular and functional characterization of allogantigen-specific anergic T cells suitable for cell therapy

Haematologica, 2010
Background CD4+ regulatory T cells are a specialized subset of T cells that actively control immune responses. Several experimental protocols have been used to expand natural regulatory T cells and to generate adaptive type 1 regulatory T cells for ...
Rosa Bacchetta, Silvia Gregori, Giorgia Serafini, Claudia Sartirana, Ute Schulz, Elisabetta Zino, Stefan Tomiuk, Uwe Jansen, Maurilio Ponzoni, Carlo Terenzio Paties, Katharina Fleischhauer, Maria Grazia Roncarolo   +11 more
doaj   +1 more source

Annexin-coated particles induce antigen-specific immunosuppression

Autoimmunity, 2020
Apoptotic cells mediate the development of tolerogenic dendritic cells (DC) and thus facilitate induction and maintenance of peripheral tolerance. Following the identification of the evolutionary conserved annexin core domain (Anx) as a specific signal ...
Corinna Link, Fatmire Bujupi, Peter H. Krammer, Heiko Weyd   +3 more
doaj   +1 more source

Tolerogenic function of Blimp-1 in dendritic cells [PDF]

Journal of Experimental Medicine, 2011
Blimp-1 has been identified as a key regulator of plasma cell differentiation in B cells and effector/memory function in T cells. We demonstrate that Blimp-1 in dendritic cells (DCs) is required to maintain immune tolerance in female but not male mice. Female mice lacking Blimp-1 expression in DCs (DCBlimp-1ko) or haploid for Blimp-1 expression exhibit
Kim, Sun Jung, Zou, Yong Rui, Goldstein, Jordan, Reizis, Boris, Diamond, Betty   +4 more
openaire   +3 more sources

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Applications of Antibody-Based Antigen Delivery Targeted to Dendritic Cells In Vivo

Antibodies, 2022
Recombinant immunoglobulins, derived from monoclonal antibodies recognizing the defined surface epitopes expressed on dendritic cells, have been employed for the past two decades to deliver antigens to dendritic cells in vivo, serving as critical tools ...
Jessica Bourque, Daniel Hawiger
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source