Results 41 to 50 of about 24,183 (235)

The Role of Tolerogenic Dendritic Cell Therapy in Autoimmune Diseases

مجله دانشکده پزشکی اصفهان, 2018
Dendritic cells (DCs) are special antigen-presenting cells that are important for activation of immune response and tolerance. Dendritic cells have been divided in two subtypes of conventional and plasmacytoid dendritic cells.
Maryam Shahidi, Seyed Mahmoud Hashemi, Davar Amani, Kaveh Baghaei   +3 more
doaj   +1 more source

Immature and maturation-resistant human dendritic cells generated from bone marrow require two stimulations to induce T cell anergy in vitro. [PDF]

, 2009
Immature dendritic cells (DC) represent potential clinical tools for tolerogenic cellular immunotherapy in both transplantation and autoimmunity. A major drawback in vivo is their potential to mature during infections or inflammation, which would convert
Ester Müller, Schäfer, Michaela, Thomas G Berger, Lutz, Manfred B., Schäfer Michaela, Schulze-Koops Hendrik, Schulze-Koops, Hendrik, Thomas G. Berger, Berger, Thomas G., Müller Ester, Michaela Schäfer, Manfred B Lutz, Müller, Ester, Manfred B. Lutz, Berger Thomas G., Hendrik Schulze-Koops, Lutz Manfred B.   +16 more
core   +1 more source

Indoleamine 2,3-Dioxygenase and Dendritic Cell Tolerogenicity [PDF]

Immunological Investigations, 2012
This article summarizes the molecular and cellular mechanisms that regulate the activity of indoleamine 2,3-dioxygenase (IDO), a potent immune-suppressive enzyme, in dendritic cells (DCs). Specific attention is given to differential up-regulation of IDO in distinct DC subsets, its function in immune homeostasis/autoimmunity, infection and cancer; and ...
Jamie L, Harden, Nejat K, Egilmez
openaire   +2 more sources

A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells [PDF]

, 2007
Viral mutational escape can reduce or abrogate recognition by the T cell receptor (TCR) of virus-specific CD8+ T cells. However, very little is known about the impact of cytotoxic T lymphocyte (CTL) epitope mutations on interactions between peptide–major
Feeney, M, Allgaier, Rachel, Marcus Altfeld, Feeney, Margaret, Williams, KL, Sivamurthy, R, Pereyra, F, Allgaier, R, Rohini Sivamurthy, Stanley K. Mui, Rosenberg, Eric S, Allen, Todd M, Altfeld, M, Eric S. Rosenberg, Pereyra, Florencia, Rachel Allgaier, Trocha, Alicja, Todd M. Allen, Moza, Beenu, Allen, TM, Eric J. Sundberg, Mui, SK, Bruce D. Walker, Sundberg, EJ, Katie L. Williams, Gandhi, RT, Yu, Xu G, Rachel Allen, Daniel G. Kavanagh, Beenu Moza, Sundberg, Eric J, Alicja Trocha, Gandhi, Rajesh T, Moza, B, Margaret Feeney, Xu G. Yu, Rosenberg, ES, Mui, Stanley K, Mathias Lichterfeld, Florencia Pereyra, Walker, BD, Rajesh T. Gandhi, Sivamurthy, Rohini, Kavanagh, DG, Trocha, A, Lichterfeld, Mathias, Allen, R, Lichterfeld, M, Williams, Katie L, Allen, Rachel, ToshiYuki Miura, Miura, ToshiYuki, Walker, Bruce D, Miura, T, Yu, XG, Kavanagh, Daniel G, Altfeld, Marcus   +56 more
core   +1 more source

Regulatory immune cells in transplantation. [PDF]

, 2012
Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control both the innate immune response triggered by the injured ...
Bushell, Andrew, Wood, Kathryn, Bushell, A, Hester, J, Wood, Kathryn J, Andrew Bushell, Joanna Hester, Kathryn J. Wood, Wood, KJ, Hester, Joanna   +9 more
core   +1 more source

Tolerogenic Dendritic Cells and T-Regulatory Cells at the Clinical Trials Crossroad for the Treatment of Autoimmune Disease; Emphasis on Type 1 Diabetes Therapy

Frontiers in Immunology, 2019
Tolerogenic dendritic cells and T-regulatory cells are two immune cell populations with the potential to prevent the onset of clinical stage type 1 diabetes, and manage the beginning of underlying autoimmunity, at the time-at-onset and onwards.
Brett Eugene Phillips, Yesica Garciafigueroa, Carl Engman, Massimo Trucco, Massimo Trucco, Nick Giannoukakis, Nick Giannoukakis   +6 more
doaj   +1 more source

Protocol of generation of tolerogenic dendritic cells affects their transcriptional and metabolic profiles leading to specific tolerogenic functions. [PDF]

Mol Ther Methods Clin Dev
International audienceCell therapy is a promising approach for inducing tolerance and thus reducing the use of immunosuppressive drugs in several immune-mediated conditions.
Suuring M, Amodio G, Rouel M, Raux A, Delhaye T, Royer AL, Cloteau C, Lavercan D, Rondeau D, Chiffoleau E, Santoni de Sio F, Croyal M, Gregori S, Moreau A.   +13 more
europepmc   +2 more sources

Dectin-1 Binding to Annexins on Apoptotic Cells Induces Peripheral Immune Tolerance via NADPH Oxidase-2

Cell Reports, 2019
Summary: Uptake of apoptotic cells (ACs) by dendritic cells (DCs) and induction of a tolerogenic DC phenotype is an important mechanism for establishing peripheral tolerance to self-antigens.
Kevin Bode, Fatmire Bujupi, Corinna Link, Tobias Hein, Stephanie Zimmermann, Diluka Peiris, Vincent Jaquet, Bernd Lepenies, Heiko Weyd, Peter H. Krammer   +9 more
doaj   +1 more source

In situ characterisation of CD4+ t cell behaviour in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance [PDF]

, 2005
The behavior of antigen-specific CD4+ T lymphocytes during initial exposure to antigen probably influences their decision to become primed or tolerized, but this has not been examined directly in vivo.
Smith, Karen M, Zinselmeyer, BH, Zinselmeyer, Bernd H, Smith, KM, Rush, C.M., Rush, Catherine M., Michael Cahalan, Ho, H., Smith, K.M., Ian Parker, Wokosin, D, Rush, Catherine M, Cahalan, M., Cahalan, Michael, Miller, M., Dempster, J., Millington, OR, Gurney, Alison M.; id_orcid, Parker, I., Ho, Hsiang, Calahan, M., Mark Miller, Millington, Owain R., Parker, I, Rush, CM, Garside, P, Alison M. Gurney, Millington, Owain R, Bernd H. Zinselmeyer, Gurney, A.M., Dempster, J, Wokosin, D.L., Paul Garside, Owain R. Millington, Millington, O.R., Catherine M. Rush, Smith, Karen M., Wokosin, D., Hsiang Ho, Dempster, John, Karen M. Smith, John Dempster, Parker, Ian, Gurney, Alison M, Brewer, James M, Gurney, Alison M., Ho, H, Cahalan, M, Millington, A.R., Wokosin, David, Zinselmeyer, B.H., Zinselmeyer, B. H., Brewer, James M., Brewer, J.M., Miller, M, Gurney, AM, David Wokosin, Garside, P., Zinselmeyer, Bernd H., Miller, Mark, James M. Brewer, Garside, Paul, Brewer, JM   +62 more
core   +1 more source

Molecular Mechanisms of Induction of Tolerant and Tolerogenic Intestinal Dendritic Cells in Mice

Journal of Immunology Research, 2016
How does the host manage to tolerate its own intestinal microbiota? A simple question leading to complicated answers. In order to maintain balanced immune responses in the intestine, the host immune system must tolerate commensal bacteria in the gut ...
Alex Steimle, Julia-Stefanie Frick
doaj   +1 more source