Results 41 to 50 of about 4,498,564 (240)

Regulatory immune cells in transplantation. [PDF]

, 2012
Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control both the innate immune response triggered by the injured ...
Bushell, Andrew, Wood, Kathryn, Bushell, A, Hester, J, Wood, Kathryn J, Andrew Bushell, Joanna Hester, Kathryn J. Wood, Wood, KJ, Hester, Joanna   +9 more
core   +1 more source

Tolerogenic Dendritic Cells and T-Regulatory Cells at the Clinical Trials Crossroad for the Treatment of Autoimmune Disease; Emphasis on Type 1 Diabetes Therapy

Frontiers in Immunology, 2019
Tolerogenic dendritic cells and T-regulatory cells are two immune cell populations with the potential to prevent the onset of clinical stage type 1 diabetes, and manage the beginning of underlying autoimmunity, at the time-at-onset and onwards.
Brett Eugene Phillips, Yesica Garciafigueroa, Carl Engman, Massimo Trucco, Massimo Trucco, Nick Giannoukakis, Nick Giannoukakis   +6 more
doaj   +1 more source

Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications [PDF]

Immune Network, 2016
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that bridge innate and adaptive immune responses, thereby leading to immune activation. DCs have been known to recognize pathogen-associated molecular patterns such as lipopolysaccharides (LPS) and nucleic acids via their pattern recognition receptors, which trigger signaling of ...
Yoo, Seungbo, Ha, Sang-Jun
openaire   +2 more sources

Sitagliptin Induces Tolerogenic Human Dendritic Cells

International Journal of Molecular Sciences, 2023
Sitagliptin, an anti-diabetic drug, is a dipeptidyl peptidase (DPP)-4/CD26 inhibitor with additional anti-inflammatory and immunomodulatory properties. In this study, we investigated for the first time the effect of sitagliptin on the differentiation and functions of human dendritic cells generated from monocytes (MoDCs) for 4 days using the standard ...
Marija Drakul, Sergej Tomić, Marina Bekić, Dušan Mihajlović, Miloš Vasiljević, Sara Rakočević, Jelena Đokić, Nikola Popović, Dejan Bokonjić, Miodrag Čolić   +9 more
openaire   +3 more sources

Indoleamine 2,3-Dioxygenase and Dendritic Cell Tolerogenicity [PDF]

Immunological Investigations, 2012
This article summarizes the molecular and cellular mechanisms that regulate the activity of indoleamine 2,3-dioxygenase (IDO), a potent immune-suppressive enzyme, in dendritic cells (DCs). Specific attention is given to differential up-regulation of IDO in distinct DC subsets, its function in immune homeostasis/autoimmunity, infection and cancer; and ...
Jamie L, Harden, Nejat K, Egilmez
openaire   +2 more sources

Dectin-1 Binding to Annexins on Apoptotic Cells Induces Peripheral Immune Tolerance via NADPH Oxidase-2

Cell Reports, 2019
Summary: Uptake of apoptotic cells (ACs) by dendritic cells (DCs) and induction of a tolerogenic DC phenotype is an important mechanism for establishing peripheral tolerance to self-antigens.
Kevin Bode, Fatmire Bujupi, Corinna Link, Tobias Hein, Stephanie Zimmermann, Diluka Peiris, Vincent Jaquet, Bernd Lepenies, Heiko Weyd, Peter H. Krammer   +9 more
doaj   +1 more source

Molecular Mechanisms of Induction of Tolerant and Tolerogenic Intestinal Dendritic Cells in Mice

Journal of Immunology Research, 2016
How does the host manage to tolerate its own intestinal microbiota? A simple question leading to complicated answers. In order to maintain balanced immune responses in the intestine, the host immune system must tolerate commensal bacteria in the gut ...
Alex Steimle, Julia-Stefanie Frick
doaj   +1 more source

Antigen-specific tolerogenic dendritic cells ameliorate the severity of murine collagen-induced arthritis. [PDF]

PLoS ONE, 2015
Dendritic cells (DCs) play important roles in initiation of the pathogenic processes of autoimmune disorders, such as rheumatoid arthritis (RA). Tolerogenic dendritic cells (tolDCs) are generated from naïve DCs and induce T cell tolerance; thus, they ...
Bin Ning, Jianlu Wei, Aijun Zhang, Weiming Gong, Jinqiu Fu, Tanghong Jia, Shang-You Yang   +6 more
doaj   +1 more source

The Long Noncoding RNA MALAT1 Induces Tolerogenic Dendritic Cells and Regulatory T Cells via miR155/Dendritic Cell-Specific Intercellular Adhesion Molecule-3 Grabbing Nonintegrin/IL10 Axis

Frontiers in Immunology, 2018
By shaping T cell immunity, tolerogenic dendritic cells (tDCs) play critical roles in the induction of immune tolerance after transplantation. However, the role of long noncoding RNAs (lncRNAs) in the function and immune tolerance of dendritic cells (DCs)
Jian Wu, Jian Wu, Hanlu Zhang, Hanlu Zhang, Yang Zheng, Yang Zheng, Xiangyuan Jin, Mingyang Liu, Mingyang Liu, Shuang Li, Shuang Li, Qi Zhao, Qi Zhao, Xianglan Liu, Xianglan Liu, Yongshun Wang, Ming Shi, Shengnan Zhang, Shengnan Zhang, Jinwei Tian, Jinwei Tian, Yong Sun, Yong Sun, Maomao Zhang, Maomao Zhang, Bo Yu, Bo Yu   +26 more
doaj   +1 more source

Functional Ambivalence of Dendritic Cells: Tolerogenicity and Immunogenicity

International Journal of Molecular Sciences, 2021
Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) and inducers of T cell-mediated immunity. Although DCs play a central role in promoting adaptive immune responses against growing tumors, they also establish and maintain peripheral tolerance.
Ji-Hee Nam, Jun-Ho Lee, So-Yeon Choi, Nam-Chul Jung, Jie-Young Song, Han-Geuk Seo, Dae-Seog Lim   +6 more
openaire   +2 more sources