Results 61 to 70 of about 24,183 (235)
Annexin-coated particles induce antigen-specific immunosuppression
Autoimmunity, 2020 Apoptotic cells mediate the development of tolerogenic dendritic cells (DC) and thus facilitate induction and maintenance of peripheral tolerance. Following the identification of the evolutionary conserved annexin core domain (Anx) as a specific signal ...
Corinna Link +3 more
doaj +1 more source
Role of regulatory T cells in immune tolerance [PDF]
, 2009 In this present work, we investigated the role of dendritic cells (DC) and regulatory T cells (Treg) in immune tolerance as well as their potential in the treatment of autoimmune or graft versus host (GvH) diseases.
Swee, Lee Kim
core +1 more source
Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage
Journal of Immunology Research, 2015 Dendritic cells (DCs), the most important professional antigen-presenting cells (APC), play crucial role in both immunity and tolerance. It is well known that DCs are able to mount immune responses against foreign antigens and simultaneously tolerate ...
Priscila de Matos Silva +7 more
doaj +1 more source
Haematologica, 2010 Background CD4+ regulatory T cells are a specialized subset of T cells that actively control immune responses. Several experimental protocols have been used to expand natural regulatory T cells and to generate adaptive type 1 regulatory T cells for ...
Rosa Bacchetta +11 more
doaj +1 more source
Semen Promotes the Differentiation of Tolerogenic Dendritic Cells [PDF]
The Journal of Immunology, 2012 Abstract Seminal plasma is not just a carrier for spermatozoa. It contains high concentrations of cytokines, chemokines, and other biological compounds that are able to exert potent effects on the immune system of the receptive partner.
Federico, Remes Lenicov +12 more
openaire +2 more sources
Advanced Science, EarlyView.Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang +8 more
wiley +1 more source
Applications of Antibody-Based Antigen Delivery Targeted to Dendritic Cells In Vivo
Antibodies, 2022 Recombinant immunoglobulins, derived from monoclonal antibodies recognizing the defined surface epitopes expressed on dendritic cells, have been employed for the past two decades to deliver antigens to dendritic cells in vivo, serving as critical tools ...
Jessica Bourque, Daniel Hawiger
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao +12 more
wiley +1 more source
Decernotinib induced tolerogenic dendritic cells alleviates experimental autoimmune neuritis
, 2023 As a potent JAK inhibitor, VX-509 inhibits the maturation of dendritic cells and induces their transformation into tolerant dendritic cells. The adoptive transfer of VX-509 induced tolerogenic dendritic cells can reduce the severity of experimental ...
Li, J (via Mendeley Data)
core +1 more source
Tolerogenic vaccination reduced effector memory CD4 T cells and induced effector memory Treg cells for type I diabetes treatment. [PDF]
PLoS ONE, 2013 BACKGROUND: Vaccination could induce immune tolerance and protected NOD mice from the development of type I diabetes (T1D). We previously demonstrated that insulin peptide (B9-23) combined with dexamethasone (DEX) stimulated the expansion of antigen ...
Jingyao Zhang +8 more
doaj +1 more source