Results 81 to 90 of about 24,183 (235)

Studies of clinically applicable human tolerogenic dendritic cells and PD-L2 genetic modification of human islet allograft to promote graft tolerance. [PDF]

, 2011
Islet transplantation is a developing therapy for type 1 diabetic patients (T1D), which has been limited by problems associated with hypoxia, poor revascularisation and allograft rejection.
Rojas-Canales, Darling
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Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

TLR-4 agonism induces CD25+ MHCIIhigh dendritic cells in association with tolerogenic antigen recognition

, 2023
Autoimmune disease is a result of the breakdown in immunological self-tolerance leading \nto destruction of self-tissues mediated by the aberrant immune attack.
Bastian, Alexander Gevelinger, NC DOCKS at East Carolina University   +1 more
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Data for: Multidimensional analyses of proinsulin peptide-specific regulatory T cells induced by tolerogenic dendritic cells

, 2019
CyTOF data: T cells stimulated with tolerogenic dendritic cells (TtolDC) or inflammatory dendritic cells (TmDC).Cells are labelled with 35 metal-tagged antibodies and acquired in CyTOF 2. Files are exported after gating for singlets and CD45+
Roep, B
core   +2 more sources

Tolerogenic dendritic cells as a therapy for treating lupus

Clinical Immunology, 2013
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that is characterized by the over production of auto-antibodies against nuclear components. Thus, SLE patients have increased morbidity and, mortality compared to healthy individuals. Available therapies are not curative and are associated with unwanted adverse effects. During the last
Llanos, Carolina, Pablo Mackern-Oberti, Juan, Vega, Fabian, Jacobelli, Sergio H., Kalergis, Alexis M.   +4 more
openaire   +19 more sources

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Hypoxia promotes the tolerogenic phenotype of plasmacytoid dendritic cells in head and neck squamous cell carcinoma

Cancer Medicine, 2022
Objective We aim to review the roles of plasmacytoid dendritic cells (pDCs) in head and neck squamous cell carcinoma (HNSCC) and explore the effects of hypoxia on the tolerogenic transformation of pDCs.
Cui Fan, Jichang Wu, Yilin Shen, Haixia Hu, Quan Wang, Yufeng Mao, Bin Ye, Mingliang Xiang   +7 more
doaj   +1 more source

In Vitro Model of Suppression of the Alloantigen Response by Tolerogenic Dendritic Cells Transfected with Personalized DNA Constructs Encoding HLA Epitopes

Frontiers in Bioscience-Landmark, 2022
Background: A search for efficient graft rejection modulation techniques for the promotion of durable engraftment remains to be a matter of close study all over the world.
Julia A. Shevchenko, Julia A. Lopatnikova, Julia N. Khantakova, Alexander N. Silkov, Maria S. Kuznetsova, Vasiliy V. Kurilin, Amir Z. Maksyutov, Sergey V. Sennikov   +7 more
doaj   +1 more source

Autoreactivity vs autoimmunity: characteristics of autoantigen‐specific CD4 T‐cells in rheumatoid arthritis and health.

Arthritis &Rheumatology, Accepted Article.
Background CD4 T cells specific for citrullinated (cit)‐peptides are key players in RA immunopathogenesis. Characterising these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next generation of RA treatments.
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source

Dendritic cell regulation of immunity to Leishmania donovani [PDF]

, 2010
Dendritic cells lie at the interface of innate and adaptive immunity, critically contributing to the generation of an antigen-specific immune response.
Owens, Benjamin M.J., Owens, Benjamin M J   +1 more
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