Results 21 to 30 of about 4,498,564 (240)

Tolerogenic Dendritic Cells [PDF]

Annual Review of Immunology, 2003
▪ Abstract  Dendritic cells (DCs) have several functions in innate and adaptive immunity. In addition, there is increasing evidence that DCs in situ induce antigen-specific unresponsiveness or tolerance in central lymphoid organs and in the periphery. In the thymus DCs generate tolerance by deleting self-reactive T cells.
Steinman, Ralph M., Hawiger, Daniel, Nussenzweig, Michel C.   +2 more
openaire   +2 more sources

Induction of Tolerogenic Dendritic Cells by a Noncoding Oligonucleotide. [PDF]

Eur J Immunol
ABSTRACT Tolerogenic dendritic cells (tolDCs) that dampen T cell responses can be induced from blood monocytes in vitro using factors such as Vitamin D3 (VitD), dexamethasone, IL‐10, or rapamycin. However, challenges remain in obtaining robust and efficient generation of cell therapy‐based tolDCs without ...
Kamal K, Trumbo J, Richardsdotter-Andersson E, Wahren-Herlenius M, Spetz AL.   +4 more
europepmc   +3 more sources

Tolerogenic dendritic cells [PDF]

Seminars in Immunopathology, 2016
Deficits in immunological tolerance against self-antigens and antigens provided by the diet and commensal microbiota can result in the development of inflammatory and autoimmune disorders. Dendritic cells (DCs) are pivotal regulators of the immune response, specialized in antigen presentation to drive T cell priming and differentiation. DCs also have a
Maisa C. Takenaka, Francisco J. Quintana
openaire   +2 more sources

In situ characterisation of CD4+ t cell behaviour in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance [PDF]

, 2005
The behavior of antigen-specific CD4+ T lymphocytes during initial exposure to antigen probably influences their decision to become primed or tolerized, but this has not been examined directly in vivo.
Cahalan, M., Miller, M., Dempster, J., Gurney, A.M., Parker, I., Zinselmeyer, B.H., Wokosin, D.L., Rush, C.M., Ho, H., Brewer, J.M., Millington, O.R., Smith, K.M., Garside, P.   +12 more
core   +4 more sources

Tolerogenic dendritic cells in organ transplantation. [PDF]

Transpl Int, 2020
Dendritic cells (DCs) are specialized cells of the innate immune system that are characterized by their ability to take up, process and present antigens (Ag) to effector T cells. They are derived from DC precursors produced in the bone marrow. Different DC subsets have been described according to lineage-specific transcription factors required for ...
Ochando J, Ordikhani F, Jordan S, Boros P, Thomson AW.   +4 more
europepmc   +4 more sources

Tolerogenic dendritic cells and their applications in transplantation [PDF]

Cellular & Molecular Immunology, 2014
In transplantation immunology, the ultimate goal is always to successfully and specifically induce immune tolerance of allografts. Tolerogenic dendritic cells (tol-DCs) with immunoregulatory functions have attracted much attention as they play important roles in inducing and maintaining immune tolerance.
Haibin, Li, Bingyi, Shi
openaire   +2 more sources

Tolerogenicity is not an absolute property of a dendritic cell [PDF]

European Journal of Immunology, 2010
AbstractPharmacological modulation is known to temper the immune capacity of DC, enhancing the notion that modulated Ag‐bearing DC might be used therapeutically to induce tolerance. We have investigated phenotypic features shared by such DC, and queried their potential to tolerize in different settings. Immature, IL‐10, TGF‐β and 1α,25‐dihydroxyvitamin
Farquhar, Claire A., Paterson, Alison M., Cobbold, Stephen P., Rueda, Hugo Garcia, Fairchild, Paul J., Yates, Stephen F., Adams, Elizabeth, Saunders, Nigel J., Waldmann, Herman, Nolan, Kathleen F.   +9 more
openaire   +3 more sources

Tolerogenic Dendritic Cell-Based Approaches in Autoimmunity [PDF]

International Journal of Molecular Sciences, 2021
Dendritic cells (DCs) dictate the outcomes of tissue-specific immune responses. In the context of autoimmune diseases, DCs instruct T cells to respond to antigens (Ags), including self-Ags, leading to organ damage, or to becoming regulatory T cells (Tregs) promoting and perpetuating immune tolerance.
Passeri, Laura, Marta, Fortunato, Bassi, Virginia, Gregori, Silvia   +3 more
openaire   +2 more sources

Ultraviolet Radiation-Induced Tolerogenic Dendritic Cells in Skin: Insights and Mechanisms. [PDF]

Cells
Ghajar-Rahimi G, Yusuf N, Xu H.
europepmc   +2 more sources

MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE

Медицинская иммунология, 2017
Autoimmune diseases  and  complications  after  transplantation  operations are  major   public health  problem, as they often  lead to deterioration in the quality  of life, reduce  work capacity  and  disability in the  population.
S. V. Sennikov, E. V. Kulikova, N. Yu. Knauer, Yu. N. Khantakova   +3 more
doaj   +1 more source