Results 11 to 20 of about 24,183 (235)
Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells [PDF]
Nature Communications, 2022 Assessing metabolic activity within single cells rather than at a population level has a number of advantages. Here, the authors use a flow and mass cytometry based approach that assess the metabolic differences between populations of human immune ...
Juraj Adamik +8 more
doaj +3 more sources
Tolerogenic dendritic cells for regulatory T cell induction in man [PDF]
Frontiers in Immunology, 2015 Dendritic cells are (DC) highly specialized professional antigen-presenting cells (APC) that regulate immune responses, maintaining the balance between tolerance and immunity. Mechanisms via which they can promote central and peripheral tolerance include
Verena eRaker +2 more
doaj +6 more sources
Tolerance through Education: How Tolerogenic Dendritic Cells Shape Immunity [PDF]
Frontiers in Immunology, 2017 Dendritic cells (DCs) are central players in the initiation and control of responses, regulating the balance between tolerance and immunity. Tolerogenic DCs are essential in the maintenance of central and peripheral tolerance by induction of clonal T ...
Matthias P. Domogalla +7 more
doaj +5 more sources
Tolerogenic Dendritic Cells [PDF]
Annual Review of Immunology, 2003 ▪ Abstract Dendritic cells (DCs) have several functions in innate and adaptive immunity. In addition, there is increasing evidence that DCs in situ induce antigen-specific unresponsiveness or tolerance in central lymphoid organs and in the periphery. In the thymus DCs generate tolerance by deleting self-reactive T cells.
Steinman, Ralph M. +2 more
openaire +4 more sources
Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD mice. [PDF]
PLoS ONE, 2014 The objective of the study was to identify immune cell populations, in addition to Foxp3+ T-regulatory cells, that participate in the mechanisms of action of tolerogenic dendritic cells shown to prevent and reverse type 1 diabetes in the Non-Obese ...
Valentina Di Caro +5 more
doaj +3 more sources
Tolerogenic dendritic cell therapy in organ transplantation [PDF]
Transplant International, 2016 Although the occurrence of acute rejection was significantly reduced and the allograft survival at 1 year was massively improved by the development of pharmacological immunosuppressive drugs, little progress has been made regarding long-term graft survival.
Moreau, Aurélie +3 more
openaire +5 more sources
TOLEROGENIC AND ACTIVATORY PLASMACYTOID DENDRITIC CELLS IN AUTOIMMUNITY [PDF]
Frontiers in Immunology, 2013 Plasmacytoid dendritic cells (pDCs) are a particular subset of DCs that link innate and adaptive immunity. They are responsible for the substantial production of type 1 interferon (IFN-I) in response to viral RNA or DNA through activation of TLR7 and 9 ...
Leslie eGuery, Stephanie eHugues
doaj +5 more sources
Generating tolerogenic dendritic cells with neuropeptides
Human Immunology, 2009 Induction of antigen-specific tolerance is critical to prevent autoimmunity, to maintain immune homeostasis, and to achieve transplant tolerance. In addition to their classic role as sentinels of the immune response, dendritic cells (DCs) play important roles in maintaining peripheral tolerance through the induction/activation of regulatory T (Treg ...
Delgado, M.
openaire +4 more sources
Sitagliptin Induces Tolerogenic Human Dendritic Cells [PDF]
International Journal of Molecular Sciences, 2023 Sitagliptin, an anti-diabetic drug, is a dipeptidyl peptidase (DPP)-4/CD26 inhibitor with additional anti-inflammatory and immunomodulatory properties. In this study, we investigated for the first time the effect of sitagliptin on the differentiation and functions of human dendritic cells generated from monocytes (MoDCs) for 4 days using the standard ...
Marija Drakul +9 more
openaire +4 more sources
Porphyromonas gingivalis outer membrane vesicles prevent the induction of tolerogenic dendritic cells by first trimester trophoblast cells [PDF]
Frontiers in ImmunologyIntroductionPeriodontitis is a risk factor for adverse pregnancy outcomes, yet the mechanisms linking Porphyromonas gingivalis (Pg) to placental immune dysregulation remain unclear. Outer membrane vesicles (OMV) derived from this pathogen act as systemic
Brenda Lara +10 more
doaj +2 more sources