Dendritic cells in human renal inflammation - Part II [PDF]
, 2011 Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses. Here, we review the available information on their role in human renal inflammation.
Elfriede Noessner +15 more
core +1 more source
Tolerogenic dendritic cells and their role in transplantation [PDF]
Seminars in Immunology, 2011 The pursuit of clinical transplant tolerance has led to enhanced understanding of mechanisms underlying immune regulation, including the characterization of immune regulatory cells, in particular antigen-presenting cells (APC) and regulatory T cells (Treg), that may play key roles in promoting operational tolerance.
Mohamed, Ezzelarab, Angus W, Thomson
openaire +2 more sources
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Efferocytosis promotes suppressive effects on dendritic cells through prostaglandin E2 production in the context of autoimmunity. [PDF]
PLoS ONE, 2013 INTRODUCTION: Efferocytosis is a crucial process by which apoptotic cells are cleared by phagocytes, maintaining immune tolerance to self in the absence of inflammation.
Irma Pujol-Autonell +10 more
doaj +1 more source
Dendritic cells in experimental renal inflammation - Part I [PDF]
, 2011 Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses.
Elfriede Noessner +15 more
core +1 more source
Dendritic cell control of tolerogenic responses [PDF]
Immunological Reviews, 2011 Summary: One of the most fundamental problems in immunology is the seemingly schizophrenic ability of the immune system to launch robust immunity against pathogens, while acquiring and maintaining a state of tolerance to the body’s own tissues and the trillions of commensal microorganisms and food antigens that confront it every day.
Santhakumar, Manicassamy +1 more
openaire +2 more sources
The Role of Tolerogenic Dendritic Cell Therapy in Autoimmune Diseases
مجله دانشکده پزشکی اصفهان, 2018 Dendritic cells (DCs) are special antigen-presenting cells that are important for activation of immune response and tolerance. Dendritic cells have been divided in two subtypes of conventional and plasmacytoid dendritic cells.
Maryam Shahidi +3 more
doaj +1 more source
The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection. [PDF]
, 2009 BACKGROUND: Leukocyte Ig-like receptors (LILR) are a family of innate immune receptors with immunomodulatory functions. High-level expression of the receptors LILRB2 (ILT4) and LILRB4 (ILT3) is a feature of tolerogenic antigen presenting cells and has ...
Lapaque Nicolas +13 more
core +3 more sources
Immature and maturation-resistant human dendritic cells generated from bone marrow require two stimulations to induce T cell anergy in vitro. [PDF]
, 2009 Immature dendritic cells (DC) represent potential clinical tools for tolerogenic cellular immunotherapy in both transplantation and autoimmunity. A major drawback in vivo is their potential to mature during infections or inflammation, which would convert
Ester Müller +16 more
core +2 more sources
A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells [PDF]
, 2007 Viral mutational escape can reduce or abrogate recognition by the T cell receptor (TCR) of virus-specific CD8+ T cells. However, very little is known about the impact of cytotoxic T lymphocyte (CTL) epitope mutations on interactions between peptide–major
Feeney, M +56 more
core +1 more source