Metabolism Is Central to Tolerogenic Dendritic Cell Function [PDF]
Mediators of Inflammation, 2016 Immunological tolerance is a fundamental tenant of immune homeostasis and overall health. Self-tolerance is a critical component of the immune system that allows for the recognition of self, resulting in hyporeactivity instead of immunogenicity ...
Wen Jing Sim +2 more
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Tolerogenic dendritic cells for regulatory T cell induction in man [PDF]
Frontiers in Immunology, 2015 Dendritic cells are (DC) highly specialized professional antigen-presenting cells (APC) that regulate immune responses, maintaining the balance between tolerance and immunity. Mechanisms via which they can promote central and peripheral tolerance include
Verena eRaker +2 more
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Transcriptomic Analysis Identifies A Tolerogenic Dendritic Cell Signature [PDF]
Frontiers in Immunology, 2021 Dendritic cells (DC) are central to regulating innate and adaptive immune responses. Strategies that modify DC function provide new therapeutic opportunities in autoimmune diseases and transplantation.
Harry Robertson +12 more
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Porphyromonas gingivalis outer membrane vesicles prevent the induction of tolerogenic dendritic cells by first trimester trophoblast cells [PDF]
Frontiers in ImmunologyIntroductionPeriodontitis is a risk factor for adverse pregnancy outcomes, yet the mechanisms linking Porphyromonas gingivalis (Pg) to placental immune dysregulation remain unclear. Outer membrane vesicles (OMV) derived from this pathogen act as systemic
Brenda Lara +10 more
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Tolerogenic Dendritic Cell-Based Approaches in Autoimmunity. [PDF]
Int J Mol Sci, 2021 Dendritic cells (DCs) dictate the outcomes of tissue-specific immune responses. In the context of autoimmune diseases, DCs instruct T cells to respond to antigens (Ags), including self-Ags, leading to organ damage, or to becoming regulatory T cells (Tregs) promoting and perpetuating immune tolerance.
Passeri L, Marta F, Bassi V, Gregori S.
europepmc +5 more sources
Tolerogenic dendritic cell reporting: Has a minimum information model made a difference? [PDF]
PeerJ, 2023 Minimum information models are reporting frameworks that describe the essential information that needs to be provided in a publication, so that the work can be repeated or compared to other work.
Ayesha Sahar +5 more
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Sustained microparticle-mediated intracellular immunomodulation enhances tolerogenic dendritic cell stability and antigen-specific Treg induction [PDF]
Frontiers in ImmunologyTolerogenic dendritic cells (tolDCs) are a promising cell therapy platform for restoring immune tolerance, but their clinical efficacy is limited by poor phenotypic stability and short in vivo persistence following transfer.
Sihan Jia +5 more
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Tolerogenic Dendritic Cells: The Pearl of Immunotherapy in Organ Transplantation
Frontiers in Immunology, 2020 Over a half century, organ transplantation has become an effective method for the treatment of end-stage visceral diseases. Although the application of immunosuppressants (IS) minimizes the rate of allograft rejection, the common use of IS bring many ...
Quan Zhuang +8 more
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PLoS ONEBackgroundTolerogenic dendritic cells have a pivotal function in treating autoimmune illnesses, atopic diseases, and neoplasms. The precise mechanism by which Tolerogenic dendritic cells function in gastric cancer remains incompletely understood ...
Shenyu Luo +7 more
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Induction of Tolerogenic Dendritic Cells by Endogenous Biomolecules: An Update
Frontiers in Immunology, 2018 The importance of microenvironment on dendritic cell (DC) function and development has been strongly established during the last two decades. Although DCs with general tolerogenic characteristics have been isolated and defined as a particular sub ...
Urban Švajger +2 more
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