Results 41 to 50 of about 4,982,676 (293)
Frontiers in Immunology, 2019 Tolerogenic dendritic cells and T-regulatory cells are two immune cell populations with the potential to prevent the onset of clinical stage type 1 diabetes, and manage the beginning of underlying autoimmunity, at the time-at-onset and onwards.
Brett Eugene Phillips +6 more
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Tolerogenic and Activatory Plasmacytoid Dendritic Cells in Autoimmunity [PDF]
Frontiers in Immunology, 2013 Plasmacytoid dendritic cells (pDCs) are a particular subset of DCs that link innate and adaptive immunity. They are responsible for the substantial production of type 1 interferon (IFN-I) in response to viral RNA or DNA through activation of TLR7 and 9. Furthermore, pDCs present antigens (Ag) and induce naïve T cell differentiation.
Guéry L, Hugues S.
openaire +5 more sources
Dendritic cells in experimental renal inflammation - Part I [PDF]
, 2011 Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses.
Elfriede Noessner +15 more
core +1 more source
Nature Communications, 2021 Nasopharyngeal carcinoma is a diverse cancer characterised by a heterogeneous microenvironment. Here, the authors use single cell sequencing to analyse the tumour microenvironment in 10 nasopharyngeal carcinoma tumours and identify different cell types ...
Yang Liu +20 more
doaj +1 more source
Fludarabine disrupts the STAT1/AhR interaction to attenuate type 1 diabetes by inducing tolerogenic dendritic cells along with targeting effector T cells. [PDF]
Mol MedRong SJ +22 more
europepmc +2 more sources
Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications [PDF]
Immune Network, 2016 Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that bridge innate and adaptive immune responses, thereby leading to immune activation. DCs have been known to recognize pathogen-associated molecular patterns such as lipopolysaccharides (LPS) and nucleic acids via their pattern recognition receptors, which trigger signaling of ...
Yoo, Seungbo, Ha, Sang-Jun
openaire +2 more sources
Frontiers in Immunology, 2018 By shaping T cell immunity, tolerogenic dendritic cells (tDCs) play critical roles in the induction of immune tolerance after transplantation. However, the role of long noncoding RNAs (lncRNAs) in the function and immune tolerance of dendritic cells (DCs)
Jian Wu +26 more
doaj +1 more source
Interferon-α abrogates tolerance induction by human tolerogenic dendritic cells. [PDF]
PLoS ONE, 2011 BACKGROUND: Administration of interferon-α (IFN-α) represents an approved adjuvant therapy as reported for malignancies like melanoma and several viral infections.
Nicole Bacher +4 more
doaj +1 more source
Sitagliptin Induces Tolerogenic Human Dendritic Cells
International Journal of Molecular Sciences, 2023 Sitagliptin, an anti-diabetic drug, is a dipeptidyl peptidase (DPP)-4/CD26 inhibitor with additional anti-inflammatory and immunomodulatory properties. In this study, we investigated for the first time the effect of sitagliptin on the differentiation and functions of human dendritic cells generated from monocytes (MoDCs) for 4 days using the standard ...
Marija Drakul +9 more
openaire +3 more sources
A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells [PDF]
, 2007 Viral mutational escape can reduce or abrogate recognition by the T cell receptor (TCR) of virus-specific CD8+ T cells. However, very little is known about the impact of cytotoxic T lymphocyte (CTL) epitope mutations on interactions between peptide–major
Feeney, M +56 more
core +1 more source