Results 51 to 60 of about 4,982,676 (293)
Molecular Mechanisms of Induction of Tolerant and Tolerogenic Intestinal Dendritic Cells in Mice
Journal of Immunology Research, 2016 How does the host manage to tolerate its own intestinal microbiota? A simple question leading to complicated answers. In order to maintain balanced immune responses in the intestine, the host immune system must tolerate commensal bacteria in the gut ...
Alex Steimle, Julia-Stefanie Frick
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Tolerance through Education: How Tolerogenic Dendritic Cells Shape Immunity
Frontiers in Immunology, 2017 Dendritic cells (DCs) are central players in the initiation and control of responses, regulating the balance between tolerance and immunity. Tolerogenic DCs are essential in the maintenance of central and peripheral tolerance by induction of clonal T ...
Matthias P. Domogalla +7 more
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Indoleamine 2,3-Dioxygenase and Dendritic Cell Tolerogenicity [PDF]
Immunological Investigations, 2012 This article summarizes the molecular and cellular mechanisms that regulate the activity of indoleamine 2,3-dioxygenase (IDO), a potent immune-suppressive enzyme, in dendritic cells (DCs). Specific attention is given to differential up-regulation of IDO in distinct DC subsets, its function in immune homeostasis/autoimmunity, infection and cancer; and ...
Jamie L, Harden, Nejat K, Egilmez
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Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells. [PDF]
PLoS Pathogens, 2018 Following repeated encounters with adenoviruses most of us develop robust humoral and cellular immune responses that are thought to act together to combat ongoing and subsequent infections.
Thi Thu Phuong Tran +7 more
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Applications of Antibody-Based Antigen Delivery Targeted to Dendritic Cells In Vivo
Antibodies, 2022 Recombinant immunoglobulins, derived from monoclonal antibodies recognizing the defined surface epitopes expressed on dendritic cells, have been employed for the past two decades to deliver antigens to dendritic cells in vivo, serving as critical tools ...
Jessica Bourque, Daniel Hawiger
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Ethyl Pyruvate Induces Tolerogenic Dendritic Cells [PDF]
Frontiers in Immunology, 2019 Dendritic cells (DC) are professional antigen presenting cells that have a key role in shaping the immune response. Tolerogenic DC (tolDC) have immuno-regulatory properties and they are a promising prospective therapy for multiple sclerosis and other autoimmune diseases. Ethyl pyruvate (EP) is a redox analog of dimethyl fumarate (Tecfidera), a drug for
Neda Djedovic +9 more
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Functional Ambivalence of Dendritic Cells: Tolerogenicity and Immunogenicity
International Journal of Molecular Sciences, 2021 Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) and inducers of T cell-mediated immunity. Although DCs play a central role in promoting adaptive immune responses against growing tumors, they also establish and maintain peripheral tolerance.
Ji-Hee Nam +6 more
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Haematologica, 2010 Background CD4+ regulatory T cells are a specialized subset of T cells that actively control immune responses. Several experimental protocols have been used to expand natural regulatory T cells and to generate adaptive type 1 regulatory T cells for ...
Rosa Bacchetta +11 more
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Nature Communications, 2023 Chronic wounds impose a significant healthcare burden to a broad patient population. Cell-based therapies, while having shown benefits for the treatment of chronic wounds, have not yet achieved widespread adoption into clinical practice.
Dominic Henn +21 more
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Liposomes loaded with vitamin D3 induce regulatory circuits in human dendritic cells
Frontiers in Immunology, 2023 IntroductionNanomedicine provides a promising platform for manipulating dendritic cells (DCs) and the ensuing adaptive immune response. For the induction of regulatory responses, DCs can be targeted in vivo with nanoparticles incorporating tolerogenic ...
Noémi Anna Nagy +12 more
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