Results 31 to 40 of about 4,982,676 (293)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

MOLECULAR AND CELLULAR MECHANISMS MEDIATED BY DENDRITIC CELLS INVOLVED IN THE INDUCTION OF TOLERANCE

Медицинская иммунология, 2017
Autoimmune diseases  and  complications  after  transplantation  operations are  major   public health  problem, as they often  lead to deterioration in the quality  of life, reduce  work capacity  and  disability in the  population.
S. V. Sennikov, E. V. Kulikova, N. Yu. Knauer, Yu. N. Khantakova   +3 more
doaj   +1 more source

Treatment of Leukemic Blood Samples with Granulocyte-Macrophage-Colony-Stimulating-Factor Combined with Prostaglandin E1 Is Associated with Reduced Frequencies of Tolerogenic Dendritic Cells and Increased Cytotoxicity Against Autologous Blasts [PDF]

Biomedicines
Hartz A, Li L, Rejeski H, Pepeldjiyska E, Rackl E, Baudrexler T, Bojko P, Schmohl J, Rank A, Schmid C, Schmetzer H.   +10 more
europepmc   +2 more sources

Tolerogenic dendritic cells and their role in transplantation [PDF]

Seminars in Immunology, 2011
The pursuit of clinical transplant tolerance has led to enhanced understanding of mechanisms underlying immune regulation, including the characterization of immune regulatory cells, in particular antigen-presenting cells (APC) and regulatory T cells (Treg), that may play key roles in promoting operational tolerance.
Mohamed, Ezzelarab, Angus W, Thomson
openaire   +2 more sources

Immature and maturation-resistant human dendritic cells generated from bone marrow require two stimulations to induce T cell anergy in vitro. [PDF]

, 2009
Immature dendritic cells (DC) represent potential clinical tools for tolerogenic cellular immunotherapy in both transplantation and autoimmunity. A major drawback in vivo is their potential to mature during infections or inflammation, which would convert
Ester Müller, Schäfer, Michaela, Thomas G Berger, Lutz, Manfred B., Schäfer Michaela, Schulze-Koops Hendrik, Schulze-Koops, Hendrik, Thomas G. Berger, Berger, Thomas G., Müller Ester, Michaela Schäfer, Manfred B Lutz, Müller, Ester, Manfred B. Lutz, Berger Thomas G., Hendrik Schulze-Koops, Lutz Manfred B.   +16 more
core   +2 more sources

In situ characterisation of CD4+ t cell behaviour in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance [PDF]

, 2005
The behavior of antigen-specific CD4+ T lymphocytes during initial exposure to antigen probably influences their decision to become primed or tolerized, but this has not been examined directly in vivo.
Cahalan, M., Miller, M., Dempster, J., Gurney, A.M., Parker, I., Zinselmeyer, B.H., Wokosin, D.L., Rush, C.M., Ho, H., Brewer, J.M., Millington, O.R., Smith, K.M., Garside, P.   +12 more
core   +4 more sources

Dendritic cell control of tolerogenic responses [PDF]

Immunological Reviews, 2011
Summary:  One of the most fundamental problems in immunology is the seemingly schizophrenic ability of the immune system to launch robust immunity against pathogens, while acquiring and maintaining a state of tolerance to the body’s own tissues and the trillions of commensal microorganisms and food antigens that confront it every day.
Santhakumar, Manicassamy, Bali, Pulendran   +1 more
openaire   +2 more sources

The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection. [PDF]

, 2009
BACKGROUND: Leukocyte Ig-like receptors (LILR) are a family of innate immune receptors with immunomodulatory functions. High-level expression of the receptors LILRB2 (ILT4) and LILRB4 (ILT3) is a feature of tolerogenic antigen presenting cells and has ...
Lapaque Nicolas, Brown Damien P, Buerki, RA, Allen, RL, Brown, DP, Trowsdale John, Allen Rachel L, Jones Des C, Anderson, KJ, Buerki Robin A, Jones, DC, Lapaque, N, Trowsdale, J, Anderson Katie J   +13 more
core   +3 more sources

The Role of Tolerogenic Dendritic Cell Therapy in Autoimmune Diseases

مجله دانشکده پزشکی اصفهان, 2018
Dendritic cells (DCs) are special antigen-presenting cells that are important for activation of immune response and tolerance. Dendritic cells have been divided in two subtypes of conventional and plasmacytoid dendritic cells.
Maryam Shahidi, Seyed Mahmoud Hashemi, Davar Amani, Kaveh Baghaei   +3 more
doaj   +1 more source

Dendritic cells in human renal inflammation - Part II [PDF]

, 2011
Dendritic cells (DCs) are bone marrow-derived professional antigen-presenting cells that act as master regulators of acquired and innate immune responses. Here, we review the available information on their role in human renal inflammation.
Elfriede Noessner, Noessner, Elfriede, Segerer, S., Noessner, E, Stephan Segerer, Nößner, E., Peter J. Nelson, Lindenmeyer, Maja, Segerer, Stephan, Lindenmeyer, M., Lindenmeyer, M, Nelson, P.J., Maja Lindenmeyer, Nelson, Peter J., Segerer, S, Nelson, P J   +15 more
core   +1 more source