Tolerogenic Dendritic Cells [PDF]
Annual Review of Immunology, 2003 ▪ Abstract Dendritic cells (DCs) have several functions in innate and adaptive immunity. In addition, there is increasing evidence that DCs in situ induce antigen-specific unresponsiveness or tolerance in central lymphoid organs and in the periphery. In the thymus DCs generate tolerance by deleting self-reactive T cells.
Steinman, Ralph M. +2 more
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Tolerogenic dendritic cells [PDF]
Seminars in Immunopathology, 2016 Deficits in immunological tolerance against self-antigens and antigens provided by the diet and commensal microbiota can result in the development of inflammatory and autoimmune disorders. Dendritic cells (DCs) are pivotal regulators of the immune response, specialized in antigen presentation to drive T cell priming and differentiation. DCs also have a
Maisa C. Takenaka, Francisco J. Quintana
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The Evaluation of the Effect of Tolerogenic Probiotics on the Maturation of Healthy Dendritic Cells versus Immature Dendritic Cells [PDF]
Iranian Journal of Immunology, 2023 Background: Dendritic cells, (DCs) as one of the important immune cell populations, are responsible for the initiation, development, and control of acquired immune responses.
Maryam Rastin +5 more
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Tolerogenic dendritic cells and their applications in transplantation [PDF]
Cellular & Molecular Immunology, 2014 In transplantation immunology, the ultimate goal is always to successfully and specifically induce immune tolerance of allografts. Tolerogenic dendritic cells (tol-DCs) with immunoregulatory functions have attracted much attention as they play important roles in inducing and maintaining immune tolerance.
Haibin, Li, Bingyi, Shi
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The role of dendritic cells and their immunometabolism in rheumatoid arthritis
Frontiers in Immunology, 2023 Dendritic cells (DCs) play crucial roles in the pathogenesis of rheumatoid arthritis (RA), a prototypic autoimmune disease characterized by chronic synovitis and joint destruction.
Yuichi Suwa +4 more
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Tolerogenicity is not an absolute property of a dendritic cell [PDF]
European Journal of Immunology, 2010 AbstractPharmacological modulation is known to temper the immune capacity of DC, enhancing the notion that modulated Ag‐bearing DC might be used therapeutically to induce tolerance. We have investigated phenotypic features shared by such DC, and queried their potential to tolerize in different settings. Immature, IL‐10, TGF‐β and 1α,25‐dihydroxyvitamin
Farquhar, Claire A. +9 more
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Differential gene expression in thrombomodulin (TM; CD141)(+) and TM(-) dendritic cell subsets. [PDF]
PLoS ONE, 2013 Previously we have shown in a mouse model of bronchial asthma that thrombomodulin can convert immunogenic conventional dendritic cells into tolerogenic dendritic cells while inducing its own expression on their cell surface.
Masaaki Toda +9 more
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Tolerogenic dendritic cells in organ transplantation [PDF]
Transplant International, 2019 Dendritic cells (DCs) are specialized cells of the innate immune system that are characterized by their ability to take up, process and present antigens (Ag) to effector T cells. They are derived from DC precursors produced in the bone marrow. Different DC subsets have been described according to lineage-specific transcription factors required for ...
Jordi Ochando +4 more
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Efferocytosis promotes suppressive effects on dendritic cells through prostaglandin E2 production in the context of autoimmunity. [PDF]
PLoS ONE, 2013 INTRODUCTION: Efferocytosis is a crucial process by which apoptotic cells are cleared by phagocytes, maintaining immune tolerance to self in the absence of inflammation.
Irma Pujol-Autonell +10 more
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Synergistic immunomodulatory combinations induce robust human tolerogenic dendritic cells for antigen-specific regulatory T cell generation. [PDF]
J Pharmacol Exp TherJia S, Mell J, Deak P.
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