Results 61 to 70 of about 4,982,676 (293)

Regulatory immune cells in transplantation. [PDF]

, 2012
Immune regulation is fundamental to any immune response to ensure that it is appropriate for the perceived threat to the host. Following cell and organ transplantation, it is essential to control both the innate immune response triggered by the injured ...
Bushell, Andrew, Wood, Kathryn, Bushell, A, Hester, J, Wood, Kathryn J, Andrew Bushell, Joanna Hester, Kathryn J. Wood, Wood, KJ, Hester, Joanna   +9 more
core   +1 more source

Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells

Mediators of Inflammation, 2016
Dendritic cells present in the digestive tract are constantly exposed to environmental antigens, commensal flora, and invading pathogens. Under steady-state conditions, these cells have high tolerogenic potential, triggering differentiation of regulatory
Julio Aliberti
doaj   +1 more source

Regulatory dendritic cells for immunotherapy in immunologic diseases

Frontiers in Immunology, 2014
We recognize well the abilities of dendritic cells to activate effector T cell responses to an array of antigens and we think of these cells in this context as pre-eminent antigen presenting cells, but dendritic cells are also critical to the induction ...
John Robert Gordon, Yanna eMa, Laura eChurchman, Sara Alicia Gordon, Wojciech eDawicki   +4 more
doaj   +1 more source

Tolerogenic effect of mouse fibroblasts on dendritic cells [PDF]

Immunology, 2016
SummaryThere is controversy about the immunomodulatory effect of fibroblasts on dendritic cells (DCs). To clarify this issue, in this study, we have evaluated different features of fibroblast‐primed DCs including their ability to express co‐inhibitory and co‐stimulatory molecules, pro‐inflammatory and anti‐inflammatory cytokines and their ability to ...
Mohsen, Khosravi-Maharlooei, MohammadReza, Pakyari, Reza B, Jalili, Sanam, Salimi-Elizei, Jacqueline C Y, Lai, Malihesadat, Poormasjedi-Meibod, Ruhangiz T, Kilani, Jan, Dutz, Aziz, Ghahary   +8 more
openaire   +2 more sources

Human Tolerogenic Dendritic Cells Regulate Immune Responses through Lactate Synthesis

, 2022
S.1075-1090Cell therapy is a promising strategy for treating patients suffering from autoimmune or inflammatory diseases or receiving a transplant. Based on our preclinical studies, we have generated human autologous tolerogenic dendritic cells (ATDCs ...
Chiffoleau, Elise, Croyal, Mikael, Louvet, Cédric, Prieur, Xavier, Even, Amandine, Alliot-Licht, Brigitte, Marin, Eros, Obermajer, Natasa, Aguesse, Audrey, Bouchet-Delbos, Laurence, Giraud, Matthieu, Hutchinson, James A., Phong Vu Manh, Thien, Renoult, Ophélie, Dalod, Marc, Josien, Régis, Moreau, Aurélie, Vanhove, Bernard, Nerriere-Daguin, Véronique, Pecqueur, Claire, Bériou, Gaelle, Geissler, Edward K., Blancho, Gilles, Managh, Amy J., Cuturi, Maria-Cristina   +24 more
core   +1 more source

Costimulatory molecules on immunogenic versus tolerogenic human dendritic cells

Frontiers in Immunology, 2013
Dendritic cells (DC) are sentinels of immunity, essential for homeostasis of T cell-dependent immune responses. Both functions of DC, initiation of antigen-specific T cell immunity and maintenance of tissue-specific tolerance originate from distinct ...
Mario eHubo, Bettina eTrinschek, Fanny eKryczanowsky, Andrea eTüttenberg, Kerstin eSteinbrink, Helmut eJonuleit   +5 more
doaj   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Tolerogenic function of Blimp-1 in dendritic cells [PDF]

Journal of Experimental Medicine, 2011
Blimp-1 has been identified as a key regulator of plasma cell differentiation in B cells and effector/memory function in T cells. We demonstrate that Blimp-1 in dendritic cells (DCs) is required to maintain immune tolerance in female but not male mice. Female mice lacking Blimp-1 expression in DCs (DCBlimp-1ko) or haploid for Blimp-1 expression exhibit
Kim, Sun Jung, Zou, Yong Rui, Goldstein, Jordan, Reizis, Boris, Diamond, Betty   +4 more
openaire   +3 more sources

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans

Topics in Cognitive Science, EarlyView., 2023
Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica, Michael Levin, Fernando E. Rosas, Karl Friston   +3 more
wiley   +1 more source