Results 141 to 150 of about 17,602,436 (258)

Cellular expression of A20 and ABIN-3 in response to Toll-like receptor-4 stimulation

, 2009
Although Toll-like receptor (TLR)-induced expression of several proinflammatory genes is required to provoke an efficient immune response, excessive or prolonged activation of TLR signaling can contribute to the development of septic shock and several ...
Carpentier, IsabelleWE148010011200050009-0009-9450-5950F51FD2CE-F0ED-11E1-A9DE-61C894A0A6B4, McCoy, Claireeditor, Beyaert, RudiWE148010006306580000-0002-5704-582XF43C694E-F0ED-11E1-A9DE-61C894A0A6B4, Verhelst, KellyUGent0020002064828010020958639721282055610000-0001-8485-3833F81EB9B8-F0ED-11E1-A9DE-61C894A0A6B4, Verstrepen, LynnUGent0019983378208010016653269771606299260000-0003-1094-8754F687A092-F0ED-11E1-A9DE-61C894A0A6B4, O'Neill, Lukeeditor, Coornaert, Beatrice8010017198869231E418-B25E-11E6-B104-2D2FD0AF0289   +6 more
core  

MIIP Inhibits Colorectal Cancer Progression by Modulating Neutrophils Infiltration and Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li, Jia Deng, Lin Sun, Shihui Wang, Huizhi Li, Jing Chen, Lipan Zhao, Xilin Shen, Yan Sun   +8 more
wiley   +1 more source

Self‐Adaptive Biomimetic Nanocomposite Hydrogel Orchestrates Dual‐Targeting and On‐Demand H2S Gasotransmission for Multifactorial Diabetic Wound Therapy

Advanced Science, EarlyView.
A self‐adaptive and biomimetic nanocomposite hydrogel is engineered to orchestrate dual‐targeting and on‐demand H2S gasotransmission for multifactorial diabetic wound therapy. By seamlessly integrating antibacterial, antioxidant, anti‐inflammatory, immunoregulatory, and pro‐angiogenic functions within a single platform, this hydrogel dynamically ...
Kefan Wu, Xiaoxue Yang, Yonghang Liu, Yi Xiao, Shiyu Meng, Ao Li, Yi Zhun Zhu, Hui Guo, Xiaolin Wang   +8 more
wiley   +1 more source

Toll-like receptor 4 knockout mice are protected against PMOS-like pathogenesis. [PDF]

Reproduction
Wiggins K, Del Mundo Z, Angulo JA, Naidu N, Saba A, Zhou L, Garcia C, Nguyen CM, Ujagar N, De La Torre JJ, De Robles G, Rivera A, Trinh D, Tinoco R, Kauffman AS, Thackray VG, Agrawal A, Seldin M, Pacheco-Sanchez G, Nicholas DA.   +19 more
europepmc   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation

Advanced Science, EarlyView.
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana, Javairia F. Rahim, Aaron P. Bernstein, Peyman Malek Mohammadi Nouri, Lyann Sim, Winnie Enns, Jenice M. Dumlao, Haiming D. Luo, Irina Chafeeva, Hong‐Ming Chen, Aizhou Wang, Jiao‐Jing Wang, Edward N. Schmidt, Zheng Jenny Zhang, Marcelo Cypel, Christopher Nguan, Matthew S. Macauley, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu   +19 more
wiley   +1 more source

Expression of Concern: Toll-like receptor 4 contributes to blood pressure regulation and vascular contraction in spontaneously hypertensive rats. [PDF]

Clin Sci (Lond)
Bomfim GF, Dos Santos RA, Oliveira MA, Giachini FR, Akamine EH, Tostes RC, Fortes ZB, Webb RC, Carvalho MHC.   +8 more
europepmc   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Phosphorylated toll-like receptor 4 defines a high-risk sepsis endotype. [PDF]

Crit Care
Mühlhaus M, Dyck B, Witowski A, Unterberg M, Wolf A, Haberl H, von Busch A, Ziehe D, Thon P, Palmowski L, Westhus B, Ehrentraut SF, Bracht T, Bayer M, Sitek B, Marcus K, Eisenacher M, Ellger B, Wappler F, Schwier E, Henzler D, Köhler T, Zarbock A, Putensen C, Frey UH, Anft M, Babel N, Nowak H, Rahmel T, Adamzik M, Rump K, Koos B, SepsisDataNet.NRW research group.   +32 more
europepmc   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Toll-like receptor 4 signaling links cytoskeletal remodeling to lipid accumulation in macrophages. [PDF]

Inflamm Regen
Wang E, Hamezah HS, Han R, Tong X.
europepmc   +1 more source