Results 91 to 100 of about 233,587 (310)

Toll-Like Receptor 3 in Liver Diseases

Gastroenterology Research and Practice, 2010
Toll-like receptor 3 (TLR3) is a member of the TLR family that can recognize double-stranded RNA (dsRNA), playing an important role in antiviral immunity.
Shi Yin, Bin Gao
doaj   +1 more source

Biomimetic Cell Membrane‐Coated Scaffolds for Enhanced Tissue Regeneration

Advanced Materials, EarlyView.
This review examines the development and use of cell membrane‐coated scaffolds in tissue engineering. Bioinspired phospholipid and glycocalyx coatings enhance anti‐fouling, anti‐thrombogenic, and selective molecular recognition properties. Native cell membrane coatings further support cell‐specific interactions, immune modulation, and reduced bacterial
Carmen Alvarez‐Lorenzo, Alejandro Ramirez‐Romero, Diana Peixoto, Maria Vivero‐Lopez, Isabel Rodríguez‐Moldes, Angel Concheiro   +5 more
wiley   +1 more source

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

Advanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac, Luv Patel, Nguyen Tran, Amarnath Singam, DongSoo Yun, Prasun Guha, Seungman Park, Chandrabali Bhattacharya   +7 more
wiley   +1 more source

The Expression of Plasmacytoid Dendritic Cells and TLR7/9-MyD88-IRAKs Pathway in Chronic Eczema Lesions

Clinical, Cosmetic and Investigational Dermatology, 2023
Jiamin Wen,1 Jitian Weng,2 Wei Lu,3 Xiaohua Tao,3 Hao Cheng,4,* Yi Tang3,* 1Department of Dermatology, People’s Hospital of Tiantai County, Zhejiang University, Taizhou, People’s Republic of China; 2School of Public Health, Hangzhou Normal ...
Wen J, Weng J, Lu W, Tao X, Cheng H, Tang Y   +5 more
doaj  

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex [PDF]

, 2000
Koji Ohashi, Volker Burkart, Stefanie B. Flohé, Hubert Kolb   +3 more
openalex   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Enhancing the Mechanical Properties of Inherently Brittle, Biobased and Biodegradable Polyhydroxybutyrate (PHB) Polymer by Cotton Fibre Reinforcement and Interfacial Grafting

Advanced Sustainable Systems, EarlyView.
This study enhances biobassed, biodegradable polyhydroxybutyrate (PHB)s strength and ductility by reinforcing it with polyvinyl alcohol (PVA)‐coated cotton fibres and further improving interfacial bonding through maleic anhydride (MA) grafting. In addition to mechanical performance, the approaches significantly improve the gas barrier properties of the
Yilin He, Vinod Kumar Kannaujiya, Linguangze Zhuo, Wilson Ling, Chun H. Wang, Cyrille Boyer, Jin Zhang   +6 more
wiley   +1 more source

Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide [PDF]

, 2000
Egil Lien, Terry K. Means, Holger Heine, Atsutoshi Yoshimura, Shoichi Kusumoto, Koichi Fukase, Matthew J. Fenton, Masato Oikawa, Nilofer Qureshi, Brian G. Monks, Robert W. Finberg, Robin R. Ingalls, Douglas T. Golenbock   +12 more
openalex   +1 more source

Heterogeneity Landscape of Circulating Tumor Cells in Clinical Utility

Advanced Therapeutics, EarlyView.
This study reports the heterogeneity spectrum of circulating tumor cells. The factors involved in the spectrum promote CTCs to overcome barriers in the metastatic cascade but impact the clinical outcome of cancer patients. In summary, the heterogeneities in association with CTCs ultimately reduce patient survival and facilitate increasing mortality of ...
Md Kowsar Alam, Lu Yanjun, Bee Luan Khoo, Tongxu Si, Heng Zou, Mengsu Yang   +5 more
wiley   +1 more source

Bacterial Lipopolysaccharide Activates NF-κB through Toll-like Receptor 4 (TLR-4) in Cultured Human Dermal Endothelial Cells [PDF]

, 2000
Emmanuelle Faure, Ozlem Equils, Peter A. Sieling, Lisa Thomas, Xiao Hui Zhang, Carsten J. Kirschning, Nadia Polentarutti, Marta Muzio, Moshe Arditi   +8 more
openalex   +1 more source