Results 161 to 170 of about 5,866,745 (304)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

The Toll-Like Receptor Signalling Pathway Is Altered in iPSC-Derived Cortical Networks From People With Bipolar Disorder. [PDF]

Bipolar Disord
Panizzutti B, Bortolasci CC, Ellis M, Spolding B, Swinton C, Truong TTT, Field C, Liu ZS, Hernández D, Roebuck G, Singh AB, Agustini B, Zazula R, Andreazza AC, Sabbagh DESE, Jeong H, Dean OM, Kim JH, Berk M, Walder K.   +19 more
europepmc   +1 more source

Association between toll-like receptor 4 expression and symptoms of major depressive disorder

, 2015
Ming-Kung Wu,1 Tiao-Lai Huang,1,2 Kai-Wei Huang,3 Ya-Ling Huang,1 Yi-Yung Hung1,4 1Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 2Genomic and Proteomic Core Laboratory, Department of ...
Huang YL, Huang TL, Huang KW, Wu MK, Hung YY   +4 more
core  

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK‐Binding Osteoclastogenic Factor

Advanced Science, EarlyView.
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park, Yeongkag Kwon, Yeonjin Lim, Jeong Woo Park, Hyun Jung Ji, Dongwook Lee, Jueun Lee, Sung‐Ho Yun, Sungho Jeong, Ho Seong Seo, Kun Cho, Cheol‐Heui Yun, Ok‐Jin Park, Seung Hyun Han   +13 more
wiley   +1 more source

Phosphorylated toll-like receptor 4 defines a high-risk sepsis endotype. [PDF]

Crit Care
Mühlhaus M, Dyck B, Witowski A, Unterberg M, Wolf A, Haberl H, von Busch A, Ziehe D, Thon P, Palmowski L, Westhus B, Ehrentraut SF, Bracht T, Bayer M, Sitek B, Marcus K, Eisenacher M, Ellger B, Wappler F, Schwier E, Henzler D, Köhler T, Zarbock A, Putensen C, Frey UH, Anft M, Babel N, Nowak H, Rahmel T, Adamzik M, Rump K, Koos B, SepsisDataNet.NRW research group.   +32 more
europepmc   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

Toll-like Receptor 8 (TLR8) Is Expressed in Mouse Hippocampal Neurons and Modulates Neuronal Excitability. [PDF]

Int J Mol Sci
Fenkart J, Santagostino A, Seidlberger S, Schmuck A, Donat K, Drexel M, Santos-Sierra S.   +6 more
europepmc   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Different toll like receptor (TLR) expression patterns in progression towards cancer

Frontiers in Immunology, 2014
Lauri eJouhi, Suvi eRenkonen, Timo eAtula, Antti eMäkitie, Caj eHaglund, Jaana eHagström   +5 more
doaj   +1 more source

Surface Calcium Enrichment of Biogenic Hydroxyapatite Regulates Macrophage Inflammation via Toll-Like Receptor 4 Signaling. [PDF]

Biomater Res
Mai M, Su M, Deng S, Lin T, Feng J, Hsu C, Li C, Guo Z, Yang X, Wu S, Chen Z.   +10 more
europepmc   +1 more source