Results 181 to 190 of about 396,801 (209)

Signalling of Toll-Like Receptors

2008
Since Toll-like receptor (TLR) signaling was found crucial for the activation of innate and adaptive immunity, it has been the focus of immunological research. There are at least 13 identified mammalian TLRs, to date, that share similarities in their extracellular and intracellular domains.
Constantinos, Brikos, Luke A J, O'Neill
openaire   +2 more sources

Viruses and Toll-like receptors

Microbes and Infection, 2003
Recently a number of viruses, including a poxvirus, herpesvirus, retrovirus and two paramyxoviruses, have been shown to activate cells via Toll-like receptor family members. Here we postulate that although activation via Toll-like receptor molecules can lead to anti-viral innate immune responses, in some cases viruses may use these responses to ...
John C, Rassa, Susan R, Ross
openaire   +2 more sources

Toll-like receptors and autoimmunity

Autoimmunity Reviews, 2008
The understanding of autoimmune diseases experienced an impressive boost since the Toll-like receptors (TLRs) have been identified as possible key players in autoimmune pathophysiology. Although these receptors recognize a variety of structures derived from viruses, bacteria and fungi leading to subsequent initiation of the relevant immune responses ...
Julia, Hurst, Philipp, von Landenberg
openaire   +2 more sources

Structure of Toll-Like Receptors

2008
The ten human Toll-like receptors are able to respond to an extremely diverse range of microbial products ranging from di- and tri-acylated lipids to nucleic acids. An understanding of the molecular structure adopted by the receptor extracellular, transmembrane, and cytoplasmic domains and the way in which these structures interact with ligands and ...
Nicholas J, Gay, Monique, Gangloff
openaire   +2 more sources

Mammalian Toll-like receptors

Annals of Allergy, Asthma & Immunology, 2002
To review the role of mammalian Toll-like receptors (TLRs) in host defense.MEDLINE search and current literature.First, TLRs participate in the recognition of molecular patterns present on microorganisms. Second, TLRs are expressed at the interface with the environment, the site of microbial invasion.
openaire   +2 more sources

Mammalian Toll-like receptors

Current Opinion in Immunology, 2003
Toll-like receptors (TLRs) are essential in the host defense against microbial pathogens. Individual TLRs recognize distinct structural components of pathogens and evoke inflammatory responses. Recent evidence indicates that TLRs recognize not only bacteria and fungi but also viruses.
openaire   +2 more sources

Toll Like Receptors

2014
Natsuko Tanimura, Kensuke Miyake
openaire   +1 more source

Toll-like receptors

Critical Care Medicine, 2005
openaire   +2 more sources

Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective

European Journal of Medicinal Chemistry, 2022
Xuefei Bao, Guoliang Chen, Yongsheng Zhang   +2 more
exaly  

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

Immunity, 2018
Kevin S Cashman, Urko M Marigorta, Matthew C Woodruff   +2 more
exaly