Results 31 to 40 of about 537,344 (241)

A Toll for lupus [PDF]

, 2005
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
Anders HJ, H-J Anders, Stacey KJ
core   +1 more source

Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response

Frontiers in Physiology, 2018
Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells.
Korbinian Bösl, Miriam Giambelluca, Markus Haug, Markus Haug, Marit Bugge, Terje Espevik, Richard K. Kandasamy, Richard K. Kandasamy, Bjarte Bergstrøm, Bjarte Bergstrøm   +9 more
doaj   +1 more source

Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. [PDF]

, 2012
BackgroundIschemia-reperfusion (I-R) injury is a sterile inflammatory process that is commonly associated with diverse clinical situations such as hemorrhage followed by resuscitation, transient embolic events, and organ transplantation.
Dodd-o, Jeffrey M, Hellman, Judith, Mesa, Kailin R, Prakash, Arun, Wilhelmsen, Kevin, Xu, Fengyun   +5 more
core   +1 more source

Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2.

Journal of Immunology, 1999
Invasive infection with Gram-positive and Gram-negative bacteria often results in septic shock and death. The basis for the earliest steps in innate immune response to Gram-positive bacterial infection is poorly understood.
A. Yoshimura, E. Lien, R. Ingalls, E. Tuomanen, R. Dziarski, D. Golenbock   +5 more
semanticscholar   +1 more source

Polymorphisms in vitamin D receptor, toll-like receptor 2 and Toll-Like receptor 4 genes links with Dengue susceptibility [PDF]

Bioinformation, 2021
Host genetic factors are known to determine disease susceptibility in dengue virus infection. Therefore, in this study association of gene polymorphisms of Vitamin D Receptor [rs731236 (Taq) and rs7975232(Apa1)], Toll-like receptor 2 [rs5743708(Arg735Gln) and rs5743704(Pro631His)] and Toll-like receptor 4 [rs4986790A/G(Asp299Gly13843) and rs4986791 C/T(
Singh, Arvind Kumar, Prakash, Shantanu, Garg, RK, Jain, Parul, Kumar, Rashmi, Jain, Amita   +5 more
openaire   +2 more sources

KITD816V+ systemic mastocytosis associated with KITD816V+ acute erythroid leukaemia: first case report with molecular evidence for same progenitor cell derivation [PDF]

, 2009
Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
H-P Horny, K K Reichard, K Sotlar, M K Foucar, S A McClintock-Treep   +4 more
core   +1 more source

Dietary Fiber Pectin Directly Blocks Toll-Like Receptor 2–1 and Prevents Doxorubicin-Induced Ileitis

Frontiers in Immunology, 2018
Dietary carbohydrate fibers are known to prevent immunological diseases common in Western countries such as allergy and asthma but the underlying mechanisms are largely unknown.
N. Sahasrabudhe, M. Beukema, Lingmin Tian, Berit Troost, J. Scholte, E. Bruininx, G. Bruggeman, M. A. van den Berg, A. Scheurink, H. Schols, M. Faas, P. de Vos   +11 more
semanticscholar   +1 more source

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype

Science Advances, 2018
Innate immune sensing is essential for the proinflammatory program in cellular senescence. Cellular senescence is a stress response program characterized by a robust cell cycle arrest and the induction of a proinflammatory senescence-associated secretory
P. Hari, F. Millar, Nuria Tarrats, Jodie Birch, A. Quintanilla, Curtis Rink, I. Fernández-Duran, M. Muir, A. Finch, V. Brunton, J. Passos, J. Morton, L. Boulter, J. Acosta   +13 more
semanticscholar   +1 more source

Lactobacillus acidophilus induces a slow but more sustained chemokine and cytokine response in naive foetal enterocytes compared to commensal Escherichia coli [PDF]

, 2010
The first exposure to microorganisms at mucosal surfaces is critical for immune maturation and gut health. Facultative anaerobic bacteria are the first to colonise the infant gut, and the impact of these bacteria on intestinal epithelial cells (IEC) may ...
Zeuthen, Louise, Fink, Lisbeth Nielsen, Metzdorff, Stine B, Kristensen, Matilde Bylov, Licht, Tine Rask, Nellemann, Christine Lydia, Frøkiær, Hanne   +6 more
core   +2 more sources

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

Molecular Neurodegeneration, 2018
Synucleinopathies of the aging population are an heterogeneous group of neurological disorders that includes Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) and are characterized by the progressive accumulation of α-synuclein in neuronal and
Changyoun Kim, B. Spencer, E. Rockenstein, H. Yamakado, M. Mante, A. Adame, J. Fields, Deborah Masliah, M. Iba, He‐Jin Lee, R. Rissman, Seung-Jae Lee, E. Masliah   +12 more
semanticscholar   +1 more source