Results 161 to 170 of about 235,198 (285)

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

Toll-like receptor 3 signaling induces interferon-induced transmembrane protein 1 in BEAS-2B cells. [PDF]

Exp Biol Med (Maywood), 2022
Dobashi M, Shiratori T, Imaizumi T, Hashimoto S, Kawaguchi S, Seya K, Tasaka S.   +6 more
europepmc   +1 more source

Increased Interleukin-17C Production by the Toll-Like Receptor 3 Ligand Poly(I:C) in Primary Cystic Fibrosis Airway Epithelial Cells

Keiko Ueno-Shuto, Megumi Hayashi, Yukihiro Tasaki, Shunsuke Kamei, Kouhei Onuki, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto   +7 more
openalex   +2 more sources

Bisarylthiourea comprising cycloalkyl-thiophene-3-carboxylate derivatives as potential human toll-like receptor (TLR2) agonists: design, synthesis, and structure–activity relationship enabling the switch from TLR2/1 to TLR2/6 activation [PDF]

Munugala Chandrakanth, Yoshikazu Honda-Okubo, Arya C. G, Deepak B. Salunke, Nikolai Petrovsky, Janardhan Banothu   +5 more
openalex   +1 more source

A Fish MDA5 Integrates Canonical RIG‐I and MDA5 Ligand Recognition

Advanced Science, EarlyView.
These results show that the large yellow croaker lacks RIG‐I, yet its MDA5 senses both 5′ppp‐dsRNA and long dsRNA. A flexible RNA‐capping loop in the MDA5 C‐terminal domain enables two ligand‐binding modes. This dual recognition signals through MAVS–STING–TBK1/IRF3 and induces type I interferons, revealing unexpected plasticity in vertebrate antiviral ...
Wenxing Li, Yuan Feng, Huazhi Chen, Jiamei Liu, Álvaro Fernández Montero, Jiangtao Gao, Jingqun Ao, Xinhua Chen   +7 more
wiley   +1 more source

COVID-19 and hypertension: Is there a role for dsRNA and activation of Toll-like receptor 3? [PDF]

Vascul Pharmacol, 2021
Dela Justina V, Giachini FR, Priviero F, Webb RC.   +3 more
europepmc   +1 more source

Fuyuan Huoxue Decoction Promotes Lumbar Interbody Fusion in Rats: Role of Macrophage‐Driven Inflammation and the TLR9/NF‐κB Pathway

Advanced Science, EarlyView.
Fuyuan Huoxue decoction improves lumbar interbody fusion in rats while reducing inflammatory macrophage activity and supporting bone‐forming stem cells. Experiments implicate extracellular DNA and TLR9/NF‐κB signaling in early responses. These findings point to coordinated control of inflammation and osteogenesis as a potential route to stronger spinal
Hongwei Gao, Han Wu, Shaorong Li, Weijian Wang, Yijian Guo, Shuai Cheng, Jiayi Sun, Jilong An, Wei Zhang   +8 more
wiley   +1 more source

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

Toll-Like Receptor 3 (TLR3) Is Engaged in the Intracellular Survival of the Protozoan Parasite <i>Leishmania (Leishmania) amazonensis</i>. [PDF]

Infect Immun, 2022
Rath CT, Vivarini ÁC, Dos Santos JV, Medina JM, Saliba AM, Mottram JC, Lima APCA, Calegari-Silva TC, Pereira RM, Lopes UG.   +9 more
europepmc   +1 more source

Additional file 3 of Phosphorylated toll-like receptor 4 defines a high-risk sepsis endotype

Madita Mühlhaus, Birte Dyck, Andrea Witowski, Matthias Unterberg, Alexander Wolf, Helge Haberl, Alexander von Busch, Dominik Ziehe, Patrick Thon, Lars Palmowski, Britta Westhus, Stefan Felix Ehrentraut, Thilo Bracht, Malte Bayer, Barbara Sitek, Katrin Marcus, Martin Eisenacher, Björn Ellger, Frank Wappler, Elke Schwier, Dietrich Henzler, Thomas Köhler, Alexander Zarbock, Christian Putensen, Ulrich Hermann Frey, Moritz Anft, Nina Babel, Hartmuth Nowak, Tim Rahmel, Michael Adamzik, Katharina Rump, Björn Koos   +31 more
openalex   +1 more source