Results 171 to 180 of about 235,198 (285)

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Toll-like receptor 3 is a potential prognosis marker and associated with immune infiltration in stomach adenocarcinoma. [PDF]

Cancer Biomark, 2022
Huang Z, He A, Wang J, Lu H, Xu X, Zhang R, Liao W, Feng Q, Wu L.   +8 more
europepmc   +1 more source

Murine Toll-like receptor 8 is a nucleic acid multi-sensor detecting 2’,3’-cyclic monophosphate guanosine as well as combinations of ribo-, deoxy-, cyclic nucleotides, and nucleosides [PDF]

Lukas Hinkelmann, Mariam Brehm, Victor Wumbor-Apin Kumbol, Hugo McGurran, Christina Krüger, Gunnar Kleinau, Patrick Scheerer, Douglas Taylor Golenbock, Lena Alexopoulou, Michael Paul Gantier, Stefan Bauer, Seija Lehnardt   +11 more
openalex   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Convergence on a Senescence‐Associated B Cell–MIF Signaling Axis in Joint Aging and Osteoarthritis Progression

Advanced Science, EarlyView.
Single‐cell and spatial transcriptomics implicate senescent B cells and macrophage migration inhibitory factor (MIF) signaling in aging and osteoarthritic joints. An injectable hydrogel combining quercetin with siRNA targeting MIF attenuates cartilage degeneration in a mouse model of osteoarthritis.
Weida Li, Yi Wang, Yongqing You, Yue Cui, Jiayun Liu, Xingbiao Ma, QiuYu Zhu, Qiang Wu, Zanjing Zhai, Zuyan Lu, Kerong Dai, Ye Sun   +11 more
wiley   +1 more source

The role of mediator suppressor of cytokine signaling (SOCS), toll-like receptor 3 (TLR-3) and nuclear factor kappa B (NFκB) on cytokine production during dengue virus infection. [PDF]

Narra J, 2023
Masyeni S, Kuntaman K, Aryati A, Sofro MA, Hadi U, Mastutik G, Purnomo W, Santosa A, Iqhrammullah M, Yohan B, Nelwan EJ, Sasmono RT.   +11 more
europepmc   +1 more source

EFFECTS OF TOLL-LIKE RECEPTOR 3 – DEPENDENT IMMUNE ACTIVATION IN MICE ARE SEX- AND TISSUE- SPECIFIC: IMPLICATIONS FOR ALCOHOL USE DISORDER

Philip Antwi‐Adjei, S. Shanmugam, Brent R. Kisby, Igor Ponomarev   +3 more
openalex   +1 more source

Loss of Lepr in Fibroblasts Drives Tumor Development by Promoting Macrophage Infiltration

Advanced Science, EarlyView.
TNFα and TGFβ signaling reprograms Lepr+ fibroblasts toward a LeprnegMmphigh inflammatory CAF (iCAF) state, with downregulation of the Tcf21‐Lepr axis contributing to this transition. Lepr loss induces Csf3, which contributes to the enhanced macrophage‐recruiting capacity of these iCAFs, thereby promoting tumor development. Thus, inflammatory signaling
Manyu Song, Wuqi Yang, Bangran Qi, Liyuan Hou, Xu Yang, Jiuzhi Xu, Shengyuan Tian, Shuiling Jin, Lu Yu, Zhengquan Yu, Min Deng, Jiaqiang Huang, Suoqin Jin, Cong Lv   +13 more
wiley   +1 more source

Transcriptomic Signatures of Chicken DF-1 Cells Following Toll-Like Receptor 3 Stimulation

JeongWoong Park, Jae-Wan Jung, Andrew Wange Bugenyi, Marc Ndimukaga, Anh Duc Truong, Jae Rung So, Nguyen Thu Uyen, Hoon Sik Jang, Ki‐Duk Song   +8 more
openalex   +2 more sources

Toll-like receptor 3-mediated modulation of umbilical cord mesenchymal stem cell phenotype and pancreatic cancer cell responses during coculture [PDF]

Ayşegül Yılmaz, Demet Kaçaroğlu
openalex   +1 more source

Extension Economists: Valued in Mission, Penalized in Practice

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT As the public engagement arm of the land‐grant mission, we argue that Extension faculty in US agricultural economics departments face an identity crossroads as they struggle for institutional support. Specifically, we argue that Extension economists function as boundary‐spanning professionals within academic structures that often devalue ...
Trey Malone, Craig W. Carpenter, Courtney Bir, Andrew J. Van Leuven, Rebecca Wasserman‐Olin, Wendong Zhang   +5 more
wiley   +1 more source