Results 211 to 220 of about 213,803 (247)

Activation of Toll-Like Receptor 3 Augments Myofibroblast Differentiation

American Journal of Respiratory Cell and Molecular Biology, 2009
Airway remodeling is observed in the airways of patients with asthma, and differentiation of fibroblasts to myofibroblasts plays a critical role in the progress of airway remodeling. Viral infection induces not only the disease development and exacerbations but also airway remodeling. The aim of this study was to evaluate whether the activation of Toll-
Hisatoshi, Sugiura, Tomohiro, Ichikawa, Akira, Koarai, Satoru, Yanagisawa, Yoshiaki, Minakata, Kazuto, Matsunaga, Tsunahiko, Hirano, Keiichiro, Akamatsu, Masakazu, Ichinose   +8 more
openaire   +2 more sources

Toll-like receptor 3 involvement in vascular function

European Journal of Pharmacology
Maintaining endothelial cell (EC) and vascular smooth muscle cell (VSMC) integrity is an important component of human health and disease because both EC and VSMC regulate various functions, including vascular tone control, cellular adhesion, homeostasis and thrombosis regulation, proliferation, and vascular inflammation.
Takayuki Matsumoto, Takayuki Nagano, Kumiko Taguchi, Tsuneo Kobayashi, Naoko Tanaka-Totoribe   +4 more
openaire   +2 more sources

A key receptor in apoptosis: Toll-like receptor 3 (TLR3).

Journal of Molecular Oncology Research, 2018
The mammals have two types of immune system as innate and acquired immunity. The innate immune system initiates inflammatory response as well as phagocytosis to microbial attack, thus forming the organism's first line of protection. This inflammatory response is the result of induction of pattern recognition receptors (PRRs) which is inherited in the ...
Asuman Deveci Ozkan, Humeyra Nur Kaleli, Suleyman Kaleli   +2 more
openaire   +1 more source

The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection

British Journal of Biomedical Science, 2018
Single nucleotide polymorphisms (SNPs) of Toll-like receptors (TLRs) are linked with functional modification of cytokine responses. In chronic hepatitis C virus (HCV) infection, studies of TLR polymorphisms have primarily targeted receptor pathways implicated in viral immune responses.
M El-Bendary, M Neamatallah, H Elalfy, T Besheer, A Elkholi, M El-Diasty, M Elsareef, M Zahran, B El-Aarag, A Gomaa, D Elhammady, M El-Setouhy, A Hegazy, G Esmat   +13 more
openaire   +2 more sources

Toll-Like Receptor 3: Involvement with Exogenous and Endogenous RNA

International Reviews of Immunology, 2010
The recognition of pathogens is assigned to an evolutionarily conserved family of receptors, the Toll-like receptors (TLRs). The investigation of RNA-based immunology has been reinvigorated with the observation that TLR3s interact with RNA (dsRNA of viral origin, poly (I:C) and endogenous RNA).
Marla Karine, Amarante, Maria Angelica Ehara, Watanabe   +1 more
openaire   +2 more sources

Crystal Structure of Human Toll-Like Receptor 3 (TLR3) Ectodomain

Science, 2005
Toll-like receptors (TLRs) play key roles in activating immune responses during infection. The human TLR3 ectodomain structure at 2.1 angstroms reveals a large horseshoe-shaped solenoid assembled from 23 leucine-rich repeats (LRRs). Asparagines conserved in the 24-residue LRR motif contribute extensive hydrogen-bonding networks for solenoid ...
Jungwoo, Choe, Matthew S, Kelker, Ian A, Wilson   +2 more
openaire   +2 more sources

Toll like receptor 3 and viral infections of nervous system

Journal of the Neurological Sciences, 2017
Members of the toll-like receptor (TLR) family are pathogen recognition receptors that recognize pathogen-associated molecular patterns. TLRs mediate the modulation of innate immune responses and influence the development of adaptive immunity. TLR3 is the first identified antiviral TLR that recognizes dsRNA.
Rajesh, Verma, Kavita, Bharti
openaire   +2 more sources

Toll-like receptor 3 is necessary for dsRNA adjuvant effects

Vaccine, 2009
Toll-like receptors (TLR) recognize pathogen associated molecular patterns, and the binding of their specific ligands triggers a proinflammatory response that helps to fight invading microorganisms, and can be harnessed to increase vaccine efficiency.
Bruno, Salaun, Maude, Greutert, Pedro, Romero   +2 more
openaire   +2 more sources

Chloroquine pretreatment inhibits toll-like receptor 3 signaling after stroke

Neuroscience Letters, 2013
Toll-like receptors (TLRs) mediated signaling is mainly implicated in inflammatory activation which contributes to the initiation and progression of stroke. Using a model of transient global cerebral ischemia (tGCI) in rats, we investigated the changes of pro-inflammation mediators and tested the effects of Chloroquine pretreatment on the expression of
Guiyun, Cui, Xinchun, Ye, Tao, Zuo, Hui, Zhao, Qiuchen, Zhao, Wei, Chen, Fang, Hua   +6 more
openaire   +2 more sources

Toll-Like Receptor 3

2022
Mohamed Mekhemar, Johannes Tölle, Christof Dörfer, Karim M. Fawzy El-Sayed   +3 more
openaire   +1 more source