Results 111 to 120 of about 371,093 (352)

Toll-like Receptor 2 and 4 (TLR2 and TLR4) Agonists Differentially Regulate Secretory Interleukin-1 Receptor Antagonist Gene Expression in Macrophages [PDF]

, 2002
Treatment of macrophages with lipopolysaccharide (LPS) from Gram-negative bacteria or peptidoglycan (PGN) from Gram-positive bacteria activates multiple intracellular signaling pathways and a large, diverse group of nuclear transcription factors.
Brown-Steinke, K., Carl, V.S., Nicklin, M.J.H., Smith, M.F.   +3 more
core   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Polymorphisms in Toll-like receptor 4 ( TLR4 ) are associated with protection against leprosy [PDF]

, 2018
Accumulating evidence suggests that polymorphisms in Toll-like receptors (TLRs) influence the pathogenesis of mycobacterial infections, including leprosy, a disease whose manifestations depend on host immune responses.
Abraham, I., Aderem, A., Bochud, P.-Y, Britton, S., Hawn, T., Janer, M., Kaplan, G., Saunderson, P., Siddiqui, M., Sinsimer, D., Tadesse Argaw, A.   +10 more
core  

Toll-like receptor 3 blockade in rhinovirus-induced experimental asthma exacerbations:A Randomized Controlled Study [PDF]

, 2017
BACKGROUND: Human rhinoviruses (HRVs) commonly precipitate asthma exacerbations. Toll-like receptor 3, an innate pattern recognition receptor, is triggered by HRV, driving inflammation that can worsen asthma.
Backer, Vibeke, Baribaud, Frédéric, Barnathan, Elliot S., Branigan, Patrick, Del Vecchio, Alfred M., Diamant, Zuzana, Eich, Andreas, Flavin, Susan, Gern, James E., Gordon, Robert, Halperin, Scott A., Herzmann, Christian, Johnston, Sebastian L., Lipworth, Brian J., Loza, Mathew J., Lutter, Rene, Mensinga, Tjeert T., Proud, David, San Mateo, Lani, Silkoff, Philip E., Singh, Dave, Sterk, Peter J., Turner, Ronald B.   +22 more
core   +3 more sources

Highly‐Conductive and Micro‐Structured Transparent Glass Substrates for Efficient and Scalable Photoelectrochemical Applications

Advanced Science, EarlyView.
This work paves the way for practical photoelectrochemical water splitting devices by addressing key upscaling challenges related to substrate conductivity, absorber inhomogeneity, and mass transfer limitations. Integrated improvements in substrate engineering, material processing, device architecture, and operational conditions allow the development ...
Telmo da Silva Lopes, Jeffrey Capitão, Amin Khan, Leonardo Rodrigues, Dzmitry Ivanou, Tânia Lopes, Paula Dias, Adélio Mendes   +7 more
wiley   +1 more source

Natural Products with Toll-Like Receptor 4 Antagonist Activity

International Journal of Inflammation, 2018
Toll-Like Receptors (TLRs) are the innate immunity receptors that play an activating role when interacting with molecules released by bacteria and viruses (PAMPs, pathogen-associated molecular patterns) or with molecules released by injured cells and ...
Monica Molteni, Annalisa Bosi, Carlo Rossetti   +2 more
doaj   +1 more source

Toll-like receptor 4 expression in the epithelium of inflammatory periapical lesions. An immunohistochemical study [PDF]

, 2015
Toll-like receptors (TLR) are essential for the innate immune response against invading pathogens and have been described in immunocompetent cells of areas affected by periapical disease.
Barbato, Ersilia, Bufo, P., Crimi, S., Dos Santos, J. N., Leonardi, R, Loreto, Carla, Musumeci, G., Pannone, G., Perrotta, R. E., Rusu, M. C.   +9 more
core   +3 more sources

Supplementary Figure 1 from Triggering of Toll-like Receptor 4 Expressed on Human Head and Neck Squamous Cell Carcinoma Promotes Tumor Development and Protects the Tumor from Immune Attack

, 2023
Mirosław J. Szczepański, Malgorzata Czystowska, Marta Szajnik, Malgorzata Harasymczuk, Michael Boyiadzis, A Kruk-Zagajewska, Witold Szyfter, J Zeromski, Theresa L. Whiteside   +8 more
openalex   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Bacterial Lipopolysaccharide Activates Toll-Like Receptor 2 and Toll-Like Receptor 4 Gene Expression in PBMC of Vechur Cattle

International Journal of Bio-Resource and Stress Management, 2021
Vechur cattle, an indigenous breed of Kerala and it is the smallest cattle breed in the world. They are highly disease resistant. The occurrence of mastitis is very Rare in this breed as compared to crossbred cattle.
R. Lakshmi, K. K. Jayavardhanan, J. Thanislass, P. Visha   +3 more
doaj