Results 201 to 210 of about 347,248 (305)

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

Proceedings of the National Academy of Sciences of the United States of America, 2010
Huan Yang, H. Hreggvidsdóttir, K. Palmblad, Haichao Wang, M. Ochani, Jianhua Li, Ben Lu, S. Chavan, M. Rosas‐Ballina, Y. Al-Abed, S. Akira, A. Bierhaus, H. Erlandsson‐Harris, U. Andersson, K. Tracey   +14 more
semanticscholar   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Pharmacological inhibition of toll-like receptor 4 suppresses ischemia-reperfusion injury-induced inflammation and improves lung allograft function after transplantation. [PDF]

JHLT Open
Goda Y, Takahashi M, Yuasa I, Shimazu Y, Date N, Tanaka S, Katsuragawa H, Ohsumi A, Nakajima D, Date H.   +9 more
europepmc   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Corrigendum: Pharmacological Inhibition of Macrophage Toll-like Receptor 4/Nuclear Factor-kappa B Alleviates Rhabdomyolysis-induced Acute Kidney Injury. [PDF]

Chin Med J (Engl)
europepmc   +1 more source

Toll-like receptor 4 pathway evolutionary trajectory and functional emergence. [PDF]

Front Immunol
Verma S, Sowdhamini R.
europepmc   +1 more source

Identification of Histone Deacetylase Inhibitor Targeting Type I Interferon and B Cell Abnormalities in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is characterized by increased Type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Discovery of Personalized Treatment for Immuno-Metabolic Depression-Focus on 11beta Hydroxysteroid Dehydrogenase Type 2 (11betaHSD2) and Toll-like Receptor 4 (TLR4) Inhibition with Enoxolone. [PDF]

Pharmaceuticals (Basel)
Murck H.
europepmc   +1 more source

Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity

Science Translational Medicine, 2015
Naphak Modhiran, D. Watterson, David A. Muller, A. K. Panetta, D. Sester, Lidong Liu, D. Hume, K. Stacey, P. Young   +8 more
semanticscholar   +1 more source