Results 231 to 240 of about 347,248 (305)

Calcium retinoate nanoparticle mediated microglial polarization to regulate inflammatory microenvironment for therapy of neuroinflammatory disease

BMEMat, EarlyView.
A nano‐drug based on retinoic acid and calcium is developed, which can be rapily endocytosed by microglia and decomposed into small molecule/ion storms in lysosomes. This nano‐drug regulates microglial phenotype switching from M1 to M2 while indirectly guiding neuronal differentiation of endogenous neural stem cells, thereby ameliorating ...
Shuo Zhang, Yuan Yao, Wenfeng Shao, Jiapei Shi, Benjie Wei, Chunhui Sun, Jingang Wang, Jiaming Shi, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Na Ren, Yuchun Tang, Wenjuan Zhou, Shuping Wang   +13 more
wiley   +1 more source

Toll-Like Receptor 4 and 8 are Overexpressed in Lung Biopsies of Human Non-small Cell Lung Carcinoma. [PDF]

Lung
Ceccarelli S, Pasqua Marzolesi V, Vannucci J, Bellezza G, Floridi C, Nocentini G, Cari L, Traina G, Petri D, Puma F, Conte C.   +10 more
europepmc   +1 more source

Cutting edge strategies for diabetic wound care: Nanotechnology, bioengineering, and beyond

BMEMat, EarlyView.
Graphical abstract illustrates the challenges in diabetic wound healing, covering pathophysiology, formulation hurdles, and emerging therapeutic strategies. It highlights the role of hyperglycemia, formulation complexities, and advanced technologies like bioprinting and AI in improving diabetic wound management. Abstract Diabetic wounds affect millions
Usama Ahmad, Wan Nurhidayah Wan Hanaffi, Anas Islam, Aimen Salman, Mohd Muazzam Khan, Faiyaz Shakeel, Qiang Cai, Xiaojun Cai, Quazi T. H. Shubhra   +8 more
wiley   +1 more source

Ionizable lipid nanoparticles of mRNA vaccines elicit NF-κB and IRF responses through toll-like receptor 4. [PDF]

NPJ Vaccines
Zelkoski AE, Lu Z, Sukumar G, Dalgard C, Said H, Alameh MG, Mitre E, Malloy AMW.   +7 more
europepmc   +1 more source

Programmatic regulation of macrophage polarization by HAp@MXene nanocomposites to promote bone repair

BMEMat, EarlyView.
HAp@MXene nanocomposites could achieve the programmed regulation of macrophage polarization. They first induce M1 polarization through magnetoelectric induction to combat infection. Subsequently, controlled Ca2+ release drives M2 polarization to promote tissue regeneration. This dual mechanism accelerates bone defect repair and highlights the potential
Laisen Cui, Haina Huang, Yubo Zheng, Jiahao Zhang, Han Hai, Kai Bian, Zhichao Feng, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Shan Lu, Bojun Xie, Ke Gao, Benjie Wei, Ya Liu, Chunhui Sun, Hong Liu, Chao Liu   +16 more
wiley   +1 more source

Toll-like receptor 4 plays a vital role in irritable bowel syndrome: a scoping review. [PDF]

Front Immunol
Wan X, Wang L, Wang Z, Wan C.
europepmc   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Cytomegalovirus Worsens Necrotizing Enterocolitis Severity in Mice via Increased Toll-Like Receptor 4 Signaling. [PDF]

Cell Mol Gastroenterol Hepatol
Scheese D, Lu P, Moore H, Tsuboi K, Tragesser C, Duess J, Raouf Z, Sampah MF, Klerk D, El Baassiri M, Jang HS, Williams-McLeod S, Ishiyama A, Steinway SN, Wang S, Wang M, Prindle T, Fulton WB, Sodhi CP, Hackam DJ.   +19 more
europepmc   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Relationship between peripheral blood endotoxin, toll-like receptor 4 expression, and postoperative infection following surgery for acute appendicitis. [PDF]

World J Gastrointest Surg
Su W, Yang T, Hu XJ, Song J, He JJ, Huang D, Zhang B, Zhao XJ, Tang F.   +8 more
europepmc   +1 more source