Results 91 to 100 of about 245,171 (291)

Kolaviron shows anti-proliferative effect and down regulation of vascular endothelial growth factor-C and toll like receptor-2 in Wuchereria bancrofti infected blood lymphocytes

Journal of Infection and Public Health, 2017
The anti-proliferative effect and down regulation of vascular endothelial growth factor C and toll like receptor-2 by kolaviron on Wuchereria bancrofti infected peripheral blood lymphocytes were investigated.
Aliyu Muhammad, Audu Funmilola, Idowu A. Aimola, Iliya S. Ndams, Mairo H. Inuwa, Andrew J. Nok   +5 more
doaj   +1 more source

The role of Toll-like receptors in skin diseases [PDF]

, 2014
The innate immune system has the ability to recognize pathogens through Toll-like receptors (TLRs), which are transmembrane glycoproteins on the cell surface.
Joanna Bacharewicz, Teresa Reduta, Iwona Flisiak   +2 more
core   +1 more source

The AUTACE That Degrades KRAS and Engages CD8+ T Cells for the Treatment of KRAS/TP53 Co‐Mutant Tumors

Advanced Science, EarlyView.
AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li, Bolin Li, Yanan Hao, Bo Pang, Pan Li, Chunli Li, Yu Tang   +6 more
wiley   +1 more source

Association between polymorphisms in the genes encoding toll-like receptors and dectin-1 and susceptibility to invasive aspergillosis: a systematic review

Revista da Sociedade Brasileira de Medicina Tropical
Invasive aspergillosis is a common fungal infection in immunocompromised individuals. Some studies have shown that toll-like receptor and dectin-1 genetic polymorphisms may alter signaling pathways, thus increasing an individual’s susceptibility to ...
Daiane de Oliveira Cunha, Jacqueline Andréia Bernardes Leão-Cordeiro, Hellen da Silva Cintra de Paula, Fábio Silvestre Ataides, Vera Aparecida Saddi, Cesar Augusto Sam Tiago Vilanova-Costa, Antonio Márcio Teodoro Cordeiro Silva   +6 more
doaj   +1 more source

Toward a porcine in vivo model to analyze the pathogenesis of TLR5-dependent enteropathies

Gut Microbes, 2020
Non-communicable diseases, such as the metabolic syndrome and inflammatory bowel disease, constitute serious public health threats in developed countries.
Robert Pieper, Niels van Best, Kira van Vorst, Friederike Ebner, Monika Reissmann, Mathias W. Hornef, Marcus Fulde   +6 more
doaj   +1 more source

Regulation of murine B cell development and function [PDF]

, 2011
Vertebrates have developed an effective and protective, yet complex and dynamic immune system to defend themselves against the many threats from microorganisms.
Flück, Lukas Andreas
core   +1 more source

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

KMRC011, an agonist of toll-like receptor 5, mitigates irradiation-induced tissue damage and mortality in cynomolgus monkeys

Journal of Immunotoxicology, 2020
In the study here, the potential applicability of KMRC011 - an agonist of toll-like receptor-5 – as a countermeasure for radiation toxicities was evaluated.
Hong-Soo Lee, Doo-Wan Cho, Ji-Seok Han, Su-Cheol Han, Sang Keun Woo, Soo-Youn Jun, Woo-Jong Lee, Susie Yoon, Son-Il Pak, Sang-Jin Lee, Eunsol Seong, Eun-Jung Park   +11 more
doaj   +1 more source

Common Variants of TLR1 Associate with Organ Dysfunction and Sustained Pro- Inflammatory Responses during Sepsis

, 2010
Background: Toll-like receptors (TLRs) are critical components for host pathogen recognition and variants in genes participating in this response influence susceptibility to infections.
Pino Yanes, Maria, Antoni Torres, Zavala Elizabeth, Villar, Jesús, Jesús Villar, Ferrer Miguel, Jesús Blanco, Pino-Yanes Maria, Espinosa Elena, García Bello, Miguel, Miguel García-Bello, Milena Casula, Ferrer Monreal, Miquel, Torres Antoni, Muriel, Arturo, Arturo Muriel, Flores Carlos, Flores, Carlos, Carlos Flores, Blanco Jesús, Torres Martí, Antoni, Villar Jesús, Almudena Corrales, Elizabeth Zavala, Blanco, Jesús, García-Bello Miguel, Miguel Ferrer, Elena Espinosa, Maria Pino-Yanes, Espinosa, Elena, Casula Milena, null null, Zavala Zegarra, Elizabeth, Muriel Arturo, Casula, Milena, GRECIA and GEN-SEP Groups, Corrales Almudena, Corrales, Almudena, GEN-SEP groups   +38 more
core   +1 more source

Receptor-like kinases and pathogen-associated molecular patterns perception in Arabidopsis [PDF]

, 2006
Comparable to the innate immune response in mammals and insects, plants possess highly specific and sensitive recognition systems for pathogen-associated molecular patterns (PAMPs), such as bacterial flagellin.
Zipfel, Cyril
core   +1 more source