Results 101 to 110 of about 219,856 (143)

Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats. [PDF]

Oncotarget, 2018
Terawaki K, Kashiwase Y, Uzu M, Nonaka M, Sawada Y, Miyano K, Higami Y, Yanagihara K, Yamamoto M, Uezono Y.   +9 more
europepmc   +1 more source

Toll-like receptor 5 and 7 expression may impact prognosis of HPV-positive oropharyngeal squamous cell carcinoma patients. [PDF]

Cancer Immunol Immunother, 2017
Jouhi L, Mohamed H, Mäkitie A, Remes SM, Haglund C, Atula T, Hagström J.   +6 more
europepmc   +1 more source

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The Effect of Denatured Flagellin on Toll-Like Receptor-5 (TLR-5) in Mice

Endocrine, Metabolic & Immune Disorders - Drug Targets, 2018
Previous studies have demonstrated that flagellin, a component of bacterial flagella, engages Toll-Like receptor 5 (TLR-5) causing the activation of the Myeloid Differentiation Factor-88 (MYD-88) pathway that leads to the production of pro-inflammatory cytokines including Tumor Necrosis Factor-alpha (TNF-α) and Interleukin-12 (IL-12).
Soha, Mcheik, Nayla S, Al-Akl, Alexander M, Abdelnoor   +2 more
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Molecular cloning and functional analysis of duck Toll-like receptor 5

Research in Veterinary Science, 2014
Toll-like receptor 5 (TLR5) is responsible for the recognition of bacterial flagellin in vertebrates. In this study, we cloned the single-exon TLR5 gene of the Maya breed of Common Shelduck (Tadorna tadorna). The TLR5 open reading frame is 2580 bp in length and encodes an 859-amino acid protein.
Dan, Xiong, Zhiming, Pan, Xilong, Kang, Jing, Wang, Li, Song, Xinan, Jiao   +5 more
openaire   +2 more sources

Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin

Journal of Structural Biology, 2012
The structure of full-length human TLR5 determined by electron microscopy single-particle image reconstruction at 26Å resolution shows that TLR5 forms an asymmetric homodimer via ectodomain interactions. The structure shows that like TLR9, TLR5 dimerizes in the absence of ligand. The asymmetry of the dimer suggests that TLR5 may recognize two flagellin
Kaifeng, Zhou, Ryuta, Kanai, Phong, Lee, Hong-Wei, Wang, Yorgo, Modis   +4 more
openaire   +2 more sources

Toll like receptor-5: protecting the gut from enteric microbes

Seminars in Immunopathology, 2007
The intestine is normally colonized by a large and diverse commensal microbiota and is occasionally exposed to a variety of potential pathogens. In recent years, there has been substantial progress made in identifying molecular mechanisms that normally serve to protect the intestine from such enteric bacteria and which may go awry in chronic idiopathic
Matam, Vijay-Kumar, Jesse D, Aitken, Andrew T, Gewirtz   +2 more
openaire   +2 more sources

Toll-Like Receptor-5 and the Innate Immune Response to Bacterial Flagellin

2002
The innate immune system identifies the presence of infection by detecting structures that are unique to microbes and that are not expressed in the host. The bacterial flagellum (Latin, a whip) confers motility, on a wide range of bacterial species. Vertebrates, plants, and invertebrates all have evolved flagellar recognition systems that are activated
K D, Smith, A, Ozinsky
openaire   +2 more sources

Molecular cloning, characterization and expression of goose Toll-like receptor 5

Molecular Immunology, 2012
Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) that are vital to activation of the innate immune system in response to invading pathogens through their recognition of pathogen-associated molecular patterns (PAMPs). TLR5 is responsible for the recognition of bacterial flagellin in vertebrates. In this study, we cloned the goose TLR5
Qiang, Fang, Zhiming, Pan, Shizhong, Geng, Xilong, Kang, Jinlin, Huang, Xiaolin, Sun, Qiuchun, Li, Yinqiang, Cai, Xinan, Jiao   +8 more
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Toll‐like receptors ‐4 and ‐5 in oral and cutaneous squamous cell carcinomas

Journal of Oral Pathology & Medicine, 2014
BackgroundOral squamous cell carcinoma (OSCC) has a worse prognosis than cutaneous squamous cell carcinoma (CSCC). Toll‐like receptor‐ 4 (TLR‐4) and TLR‐5 are transmembrane proteins that recognize endogenous and microbial agents. Their activation has been connected to cancer invasion.ObjectiveThe aim was to study the expression of TLR‐4 and TLR‐5 in ...
Korvala Johanna, Salo Tuula, Haglund Caj, Hagstrom Jaana, Kontio Risto, Virolainen Susanna, Atula Timo, Sorsa Timo, Salo Tuula, Häyry Valtteri, Haglund Caj, Hagstrom Jaana, Kontio Risto, Virolainen Susanna, Atula Timo, Sorsa Timo, Salo Tuula, Häyry Valtteri   +17 more
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Regulation of adipogenesis by toll-like receptor 5 pathway

2016
Toll-like receptor 5 (TLR5) recognizes the bacterial product, flagellin. Its activation leads to cytokine production that is important for host defense against invading pathogens. In spite of the pro-inflammatory nature of TLR5, deficiency of TLR5 exacerbated metabolic dysfunction in diet-induced obese mouse model (Gewirtz et al. Science, 328: 228-231,
YIU, JHC, LI, J, Xu, A, Woo, WHC
openaire   +2 more sources