Results 121 to 130 of about 245,171 (291)

Toll-like receptor (TLR) 2 and TLR4 gene expression in canine heart

, 2007
Toll-like receptors (TLRs) are archetypal pattern recognition receptors of immediate importance for an efficacious innate immune response. TLRs exhibit marked differential tissue activity and their levels within a discrete cell type can be highly dynamic.
Linde, Annika, Blecha, Frank, Melgarejo, Tonatiuh   +2 more
core   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity [PDF]

, 2011
The protein ABIN1 possesses a polyubiquitin-binding domain homologous to that present in nuclear factor kappa B (NF-kappa B) essential modulator (NEMO), a component of the inhibitor of NF-kappa B (I kappa B) kinase (IKK) complex.
Ordureau, Alban, David W. Powell, Rachel Toth, Venigalla, R.K.C., Toth, Rachel, Sambit K. Nanda, J. Simon C. Arthur, Toth, R., Powell, D.W., Venigalla, Ram K. C., Nanda, S.K., C. Arthur, J.S., Janet C. Patterson-Kane, Nanda, Sambit K., Cohen, P., Philip Cohen, Cohen, Philip; id_orcid, Ordureau, A., Arthur, J. Simon C.; id_orcid, Ram K.C. Venigalla, Patterson-Kane, J.C., Alban Ordureau, Patterson-Kane, Janet C., Powell, David W.   +23 more
core   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor-deficient mice. [PDF]

Hepatol Commun, 2023
Golonka RM, Yeoh BS, Saha P, Gohara A, Tummala R, Stepkowski S, Tiwari AK, Joe B, Gonzalez FJ, Gewirtz AT, Vijay-Kumar M.   +10 more
europepmc   +1 more source

Polymorphisms in bovine immune genes and their associations with somatic cell count and milk production in dairy cattle

, 2010
peer-reviewedBackground: Mastitis, an inflammation of the mammary gland, is a major source of economic loss on dairy farms. The aim of this study was to quantify the associations between two previously identified polymorphisms in the bovine toll-like ...
Magee, David A, Daly Mairead, Christine Beecher, McCarthy Tommie V, Tommie V McCarthy, Linda Giblin, David A Magee, Giblin Linda, Berry Donagh P, Magee David A, Donagh P Berry, Beecher Christine, Stuart Childs, McCarthy, Tommie V, Giblin, Linda, Mairead Daly, Beecher, Christine, Daly, Mairead, Childs, Stuart, Childs Stuart, Berry, Donagh   +20 more
core   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infraorbital blood–nerve barrier following chronic constriction injury?

Molecular Pain, 2017
Background Blood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Nathan Moreau, Annie Mauborgne, Pierre-Olivier Couraud, Ignacio A Romero, Babette B Weksler, Luis Villanueva, Michel Pohl, Yves Boucher   +7 more
doaj   +1 more source

Tetrahedral DNA Nanostructure‐Based Biomimetic Nanovesicles Attenuate Sepsis‐Associated ARDS by Suppressing Glycolysis via the BMAL1/PFKFB3 Axis

Advanced Science, EarlyView.
Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang, Bin Li, Zhijin Fan, Yan Yan, Fei Ma, Changting He, Shiping Liu, Mingliang Pan, Zhou Pan, Huijuan Wang, Xinting Fu, Jiamei Wang, Yue Jia, Qin Gu, Duo Jiang, Xueting Liu, Bohua Ren, Qinqin Wang, Yuehua Hei, Han Duan, Yanqiu Wu, Zihui Wei, Liying Zhan, Yuhui Liao   +23 more
wiley   +1 more source

Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers-Danlos syndrome. [PDF]

Sci Rep, 2023
Kamada H, Emura K, Yamamoto R, Kawahara K, Uto S, Minami T, Ito S, Matsumoto KI, Okuda-Ashitaka E.   +8 more
europepmc   +1 more source