Results 131 to 140 of about 245,171 (291)

The role of toll-like receptors in the adrenal gland

, 2010
Sepsis is caused by infection and often followed by an overwhelming inflammatory response. This can lead to shock, organ failure and even death. Each year approximately 60,000 people die in Germany due to sepsis.
Tran, Thi Hoai Nguyen
core  

Delayed Resolution of Acute Inflammation in Ulcerative Colitis Is Associated with Elevated Cytokine Release Downstream of TLR4

, 2010
Background: Ulcerative colitis (UC) is widely viewed as a leukocyte-mediated disorder. Although strong evidence implicates an exuberant response to microbial components in its pathogenesis, no intrinsic immune defect has been identified and the ...
Bu'Hussain Hayee, Bloom, SL, Hayee, B, Daniel J B Marks, Bloom Stuart L., Segal Anthony W., Anthony W Segal, Rahman Farooq Z., Smith Andrew M., Hayee Bu'Hussain, Rahman, FZ, Andrew M Smith, Stuart L Bloom, Marks, DJB, Marks Daniel J. B., Smith, AM, Farooq Z Rahman, Segal, AW   +17 more
core   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

TLR-9 Expression in Human Bronchial Epithelial Cells induced with Lipopolysaccharide

, 2010
The study conducted here was to investigate the gene and protein expression of Toll like receptor 9 when human bronchial epithelial cells were induced by lipopolysaccharide.
Sangeetha Dharmalingam, Shanmuga Saravanabhavan   +1 more
core  

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation. [PDF]

World J Gastroenterol, 2022
Mallaret G, Lashermes A, Meleine M, Boudieu L, Barbier J, Aissouni Y, Gelot A, Chassaing B, Gewirtz AT, Ardid D, Carvalho FA.   +10 more
europepmc   +1 more source

Dietary fatty acids modulate inflammatory cytokine production through activation of MAP kinases [PDF]

, 2007
Polyunsaturated fatty acids (PUFA) have therapeutic effects in inflammatory diseases, however the specific mechanisms by which they exert these effects have not yet been defined.
Braddish, Della
core  

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Identification of toll-like receptor 5 and acyl-CoA synthetase long chain family member 1 as hub genes are correlated with the severe forms of COVID-19 by Weighted gene co-expression network analysis. [PDF]

IET Syst Biol, 2023
Wang L, Mao Z, Shao F.
europepmc   +1 more source

Keratinocytes from human skin respond as typical immune cells after the stimulation with _Trichophyton rubrum_

, 2007
_Trichophyton rubrum_ is the main agent causing dermatophytosis (1). Keratinocytes are considered to be the first physical barrier of defense against pathogens (2). But not only a physical barrier.
Luz A. García-Madrid, Alfonso E. Islas-Rodríguez   +1 more
core