Results 111 to 120 of about 245,171 (291)

Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release : an observational study in three cohorts [PDF]

, 2010
Introduction: It has been proposed that individual genetic variation contributes to the course of severe infections and sepsis. Recent studies of single nucleotide polymorphisms (SNPs) within the endotoxin receptor and its signaling system showed an ...
Oh, Djin Ye, Koch, Alexander, David A Schwartz, van der Meer, Jos W. M., Latz, E., Eicke Latz, Djin-Ye Oh, Schumann, Ralf R, Schumann, R.R., Chryssanthi Skalioti, van der Meer, Jos WM, Jos WM van der Meer, Kumpf, Oliver, Skalioti, C., Eva Lorenz, van der Meer, Jos W.M., van der Meer, J.W., Schwartz, David A, Schlag, Peter M., Netea, M.G., Giamarellos-Bourboulis, Evangelos, Bart-Jan Kullberg, Kai Zacharowski, Mouktaroudi, Maria, Mouktaroudi, M., Latz, Eicke, Lorenz, Eva, Netea, Mihai G, Kumpf, O., Schlag, P.M., Kullberg, B.J., Schlag, Peter M, Peter M Schlag, Hamann, L., Lorenz, E., Kullberg, Bart Jan, Lutz Hamann, Ferwerda, B., Maria Mouktaroudi, Christina Routsi, Alexander Koch, Zacharowski, Kai, Oliver Kumpf, Schumann, Ralf R., Routsi, C., Evangelos J Giamarellos-Bourboulis, Bart Ferwerda, Mihai G Netea, Routsi, Christina, Koch, A., Schwartz, David A., Skalioti, Chryssanthi, Ralf R Schumann, Giamarellos-Bourboulis, E.J., Meer, J.W.M. van der, Kullberg, Bart-Jan, Hamann, Lutz, Netea, Mihai G., Giamarellos-Bourboulis, Evangelos J., Oh, D.Y., Schwartz, D.A., Oh, Djin-Ye, Zacharowski, K., Ferwerda, Bart, Giamarellos-Bourboulis, Evangelos J   +64 more
core   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Optineurin negatively regulates the induction of IFNβ in response to RNA virus infection [PDF]

, 2010
The innate immune response provides a critical defense against microbial infections, including viruses. These are recognised by pattern recognition receptors including Toll-like receptors (TLRs) and RIG-I like helicases (RLHs).
Harris, M., Macdonald, A., Kohl, A., Richards, KH, Wetherill, L, Kohl, Alain, MacDonald, A, Mankouri, Jamel, Kohl, A, Elliott, Richard M., Elliott, RM, Alain Kohl, Wetherill, L.F., Rennos Fragkoudis, Harris Mark, Andrew Macdonald, Richards Kathryn H., Richards, K.H., Richards, K, Laura F Wetherill, Mankouri, J., Richards, Kathryn H., Mankouri, J, Jamel Mankouri, Elliott, R.M., Wetherill Laura F., Fragkoudis, R., Richard M Elliott, Macdonald, Andrew, Harris, M, Wetherill, Laura F., Kohl Alain, Elliott Richard M., Macdonald Andrew, Wetherill, LF, Elliott, Richard Michael, Mark Harris, Harris, Mark, Fragkoudis, R, Kathryn H Richards, Fragkoudis, Rennos, Mankouri Jamel, Fragkoudis Rennos   +42 more
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Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Adipose-selective overexpression of ABHD5/CGI-58 does not increase lipolysis or protect against diet-induced obesity

Journal of Lipid Research, 2011
Adipose triglyceride lipase (ATGL) catalyzes the first step of triacylglycerol hydrolysis in adipocytes. Abhydrolase domain 5 (ABHD5) increases ATGL activity by an unknown mechanism.
Jorge M. Caviglia, Jenna L. Betters, Dianne-Helerie Dapito, Caleb C. Lord, Sean Sullivan, Streamson Chua, Terry Yin, Anna Sekowski, Haiyan Mu, Lawrence Shapiro, J. Mark Brown, Dawn L. Brasaemle   +11 more
doaj   +1 more source

The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection

, 2012
Includes abstract.Includes bibliographical references.Moderate and chronic consumption of red wine confers cardioprotection. Melatonin, present in wine, may contribute to this cardioprotective effect. Melatonin confers cardioprotection via the activation
Albertyn, Zulfah
core  

Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients

, 2011
Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs)
Carsten Schwenke, Matthias Schott, Koch, Alexander, Stefan R Bornstein, Ralf R Schumann, Schott, Matthias, Lutz Hamann, Hamann, Lutz, Bornstein, Stefan R., Schwenke, Carsten, Alexander Koch, Muhammed Kurt, Zacharowski, Kai, Kai Zacharowski, Olaf Boehm, Schumann, Ralf R., Grotemeyer, Dirk, Kurt, Muhammed, Boehm, Olaf, Dirk Grotemeyer   +19 more
core   +1 more source

Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. [PDF]

, 2011
The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but
Rupanagudi Khader Valli, Khader Valli Rupanagudi, Allam, R., Anders Hans-Joachim, Darisipudi, M.N., Ramanjaneyulu Allam, Allam Ramanjaneyulu, Murthy Narayana Darisipudi, Hans-Joachim Anders, Rupanagudi, K.V., Rupanagudi, Khader Valli, Anders, Hans-Joachim, Anders, H.J., Darisipudi, Murthy Narayana, Darisipudi Murthy Narayana, Allam, Ramanjaneyulu   +15 more
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Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source