Results 131 to 140 of about 196,754 (276)

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Increased expression of Toll-like receptors 2, 3, 4 and 7 mRNA in the kidney and intestine of a septic mouse model

, 2019
Sylvia Krivan, Alkistis Kapelouzou, Stylianos Vagios, Diamantis I. Tsilimigras, Michalis Katsimpoulas, Dimitrios Moris, Chrysostomos V. Aravanis, Theano Demesticha, Dimitriοs Schizas, Manolis Mavroidis, Kitty Pavlakis, Nikolaos Machairas, Evangelos Misiakos, Theodore Liakakos   +13 more
openalex   +1 more source

Toll-like receptor 3 signaling induces interferon-induced transmembrane protein 1 in BEAS-2B cells

, 2022
Masaki Dobashi, Toshihiro Shiratori, Tadaatsu Imaizumi, Shun Hashimoto, Shogo Kawaguchi, Kazuhiko Seya, Sadatomo Tasaka   +6 more
openalex   +2 more sources

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Cell Activation by Ligands of the Toll-Like Receptor and Interleukin-1 Receptor Family Depends on the Function of the Large-Conductance Potassium Channel MaxiK in Human Macrophages

, 2006
Olaf Scheel, Martin Papavlassopoulos, Rikard Blunck, Andreas Gebert, Thomas Härtung, Ulrich Zähringer, Ulrich Seydel, Andra B. Schromm   +7 more
openalex   +1 more source

Structure, function, and potential application of Toll-like receptor 22 from fish

, 2022
Trang Xuan Le, Mai Quốc Gia, Linh Mỹ Đào, Thao Phuong Thi Nguyen, Hieu V. Tran   +4 more
openalex   +2 more sources

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

Advanced Science, EarlyView.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng, Yunsheng Jiang, Zhiyu Chen, Kaiquan Chen, Na Cao, Yang Huang, Zhengxue Quan, Cheng Chen   +7 more
wiley   +1 more source

Toll-like receptors and their role in the pathogenesis of myasthenia gravis: a comprehensive review. [PDF]

Front Immunol
Zheng X, Li L, Ma H, Zhu M, Li X, Feng X.   +5 more
europepmc   +1 more source

P020 Toll-like receptor 9 influences inflammatory arthritis and osteoclastogenesis [PDF]

, 2018
Anita Fischer, S Abdollahi-Rodsaz, ACY Yau, Erik Lönnblom, Rikard Holmdahl, G Steiner   +5 more
openalex   +1 more source