Results 131 to 140 of about 608,641 (362)

Plaque‐Targeted Delivery of Fluoride‐Free MXene Nanozyme for Alleviating Atherosclerosis via Sonocatalytic Therapy

Advanced Materials, EarlyView.
This work has developed a dual enzyme‐mimicking and ultrasound‐responsive Nb2C‐Pt@HA‐PEG nanozyme. ROS‐eliminating and anti­inflammatory capability of Nb2C‐Pt@HA‐PEG under US irradiation are demonstrated on macrophages and endothelial cells in vitro. Nb2C‐Pt@HA‐PEG‐mediated sonocatalytic therapy exerts an outstanding anti‐atherosclerosis efficacy by ...
Qianqian Bai, Xinyue Lao, Sin‐Yi Pang, Yifei Zhao, Yuan Liu, Xiao Yu Tian, Jianhua Hao   +6 more
wiley   +1 more source

The Molecular Mechanism of B Cell Activation by toll-like Receptor Protein RP-105 [PDF]

, 1998
Vivien W. Chan, Ingrid Mecklenbräuker, I-hsin Su, Gemma Texidó, Michael Leitges, Rita Carsetti, Clifford A. Lowell, Klaus Rajewsky, Kensuke Miyake, Alexander Tarakhovsky   +9 more
openalex   +1 more source

Association between polymorphisms in the genes encoding toll-like receptors and dectin-1 and susceptibility to invasive aspergillosis: a systematic review

Revista da Sociedade Brasileira de Medicina Tropical
Invasive aspergillosis is a common fungal infection in immunocompromised individuals. Some studies have shown that toll-like receptor and dectin-1 genetic polymorphisms may alter signaling pathways, thus increasing an individual’s susceptibility to ...
Daiane de Oliveira Cunha, Jacqueline Andréia Bernardes Leão-Cordeiro, Hellen da Silva Cintra de Paula, Fábio Silvestre Ataides, Vera Aparecida Saddi, Cesar Augusto Sam Tiago Vilanova-Costa, Antonio Márcio Teodoro Cordeiro Silva   +6 more
doaj   +1 more source

Hypoxia Preconditioning Increases Survival and Decreases Expression of Toll-like Receptor 4 in Pulmonary Artery Endothelial Cells Exposed to Lipopolysaccharide [PDF]

, 2013
Pulmonary or systemic infections and hypoxemic respiratory failure are among the leading causes of admission to intensive care units, and these conditions frequently exist in sequence or in tandem.
Ali, Irshad, Audi, Said H., Densmore, John C., Husnain, Fouad, Jacobs, Elizabeth R., Konduri, G. Ganesh, Medhora, Meetha, Nanchal, Rahul   +7 more
core   +2 more sources

PiP‐Plex: A Particle‐in‐Particle System for Multiplexed Quantification of Proteins Secreted by Single Cells

Advanced Materials, EarlyView.
Detecting proteins secreted by a single cell while retaining its viability remains challenging. A particles‐in‐particle (PiPs) system made by co‐encapsulating barcoded microparticles (BMPs) with a single cell inside an alginate hydrogel particle is introduced.
Félix Lussier, Byeong‐Ui Moon, Mojra Janta‐Polczynski, Yonatan Morocz, Fabian Svahn, Molly Shen, Ljuboje Lukic, Lidija Malic, Teodor Veres, Andy Ng, David Juncker   +10 more
wiley   +1 more source

Toll-like receptors in invertebrate innate immunity [PDF]

Invertebrate Survival Journal, 2005
Among invertebrates, innate immunity is the only defense mechanism against harmful non-self agents.In response to recognition of microbial pattern molecules, Drosophila melanogaster activates either theToll or Imd pathway, leading to the translocation of
L Zheng, L Zhang, H Lin, MT McIntosh, AR Malacrida   +4 more
doaj   +2 more sources

Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression [PDF]

, 2000
Fumiko Nomura, Sachiko Akashi, Yoshimitsu Sakao, Shintaro Sato, Taro Kawai, Makoto Matsumoto, Kenji Nakanishi, Masao Kimoto, Kensuke Miyake, Kiyoshi Takeda, Shizuo Akira   +10 more
openalex   +1 more source

Toll-like receptors: the swiss army knife of immunity and vaccine development

Clinical & Translational Immunology, 2016
Innate immune cells have a critical role in defense against infection and disease. Central to this is the broad specificity with which they can detect pathogen‐associated patterns and danger‐associated patterns via the pattern recognition receptors (PRRs)
J. Dowling, A. Mansell
semanticscholar   +1 more source

Toll-Like Receptors, Tissue Injury, and Tumourigenesis

Mediators of Inflammation, 2010
Toll-like receptors (TLRs) belong to a class of molecules known as pattern recognition receptors, and they are part of the innate immune system, although they modulate mechanisms that impact the development of adaptive immune responses.
Savvas Ioannou, Michael Voulgarelis
doaj   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source