Results 31 to 40 of about 180,223 (258)

Toll Like Receptors 4 and 2 Expression in the Bronchial Mucosa of Patients with Cystic Fibrosis

Canadian Respiratory Journal, 2005
BACKGROUND: Cystic fibrosis (CF) is a lung disease characterized by chronic infection with Gram-negative bacteria Pseudomonas aeruginosa and Gram-positive bacteria Staphylococcus aureus.
Hans-Peter Hauber, Meri K Tulic, Anne Tsicopoulos, Benoit Wallaert, Ron Olivenstein, Patrick Daigneault, Qutayba Hamid   +6 more
doaj   +1 more source

IL-1 Receptor-associated kinase signaling and its role in inflammation, cancer progression and therapy resistance

Frontiers in Immunology, 2014
Chronic inflammation has long been associated with the development of cancer. Amongst the various signaling pathways within cancer cells that can incite the expression of inflammatory molecules are those that activate IL-1 receptor associated kinases ...
Ajay eJain, Sabina eKaczanowska, Eduardo eDavila   +2 more
doaj   +1 more source

EXPRESSION FEATURES OF TOLL-LIKE RECEPTOR 2 AND TOLL-LIKE RECEPTOR 4 IN CHILDREN WITH ASTHMA

Medical Immunology (Russia), 2017
Currently actively  discussed  the  role  of innate immunity receptors, in particular TLRs  in the immunopathogenesis of bronchial asthma (BA).The aim of our work was to study the expression of ТLR2 and TLR4 on the nasal mucosal cells and peripheral blood leukocytes  of patients with BA of different  severity.The study included 40 children with asthma (
L. V. Gankovskaya, L. S. Namazova-Baranova, M. V. Khoreva, B. G. Bragvadze, A. D. Ogurtsova, A. A. Alekseeva, V. А. Gankovskii, O. А. Svitich   +7 more
openaire   +3 more sources

Prognostic and clinicopathological significance of TLR4 expression in patients with breast cancer: a meta-analysis

Frontiers in Oncology
BackgroundThe prognostic value of Toll-like receptor 4 (TLR4) in breast cancer remains to be determined. Therefore, this paper aims to conduct a meta-analysis to assess the correlation between TLR4 and clinicopathological indicators as well as survival ...
Jinxu Wen, Jiayi Zhang, Xiaoyong Wu, Xuemin Yan, Xiaoru Qin, Yuexin Wang   +5 more
doaj   +1 more source

Impaired clearance of apoptotic cells leads to HMGB1 release in the bone marrow of patients with myelodysplastic syndromes and induces TLR4-mediated cytokine production

Haematologica, 2013
Excessive pro-inflammatory cytokine production in the bone marrow has been associated with the pathogenesis of myelodysplastic syndromes. We herein investigated the involvement of toll-like receptors and their endogenous ligands in the induction ...
Maria Velegraki, Evaggelia Papakonstanti, Irene Mavroudi, Maria Psyllaki, Christos Tsatsanis, Anastasis Oulas, Ioannis Iliopoulos, Pavlos Katonis, Helen A. Papadaki   +8 more
doaj   +1 more source

Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4

Immunology, 2004
SummaryAn understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort to provide a molecular basis for the lethal effect of LPS during septic shock and point the way to novel therapies. Rapid progress in this field during the last 6 years has resulted in the discovery of not only the receptor for LPS – Toll‐like receptor 4
O'NEILL, LUKE ANTHONY JOHN, PALSSON, EVA
openaire   +4 more sources

The implication of dendritic cells in lung diseases: Immunological role of toll-like receptor 4

Genes and Diseases
The immune responses play a profound role in the progression of lung lesions in both infectious and non-infectious diseases. Dendritic cells, as the “frontline” immune cells responsible for antigen presentation, set up a bridge between innate and ...
Shurui Xuan, Yuan Ma, Honglei Zhou, Shengwei Gu, Xin Yao, Xiaoning Zeng   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Association between polymorphisms in the genes encoding toll-like receptors and dectin-1 and susceptibility to invasive aspergillosis: a systematic review

Revista da Sociedade Brasileira de Medicina Tropical
Invasive aspergillosis is a common fungal infection in immunocompromised individuals. Some studies have shown that toll-like receptor and dectin-1 genetic polymorphisms may alter signaling pathways, thus increasing an individual’s susceptibility to ...
Daiane de Oliveira Cunha, Jacqueline Andréia Bernardes Leão-Cordeiro, Hellen da Silva Cintra de Paula, Fábio Silvestre Ataides, Vera Aparecida Saddi, Cesar Augusto Sam Tiago Vilanova-Costa, Antonio Márcio Teodoro Cordeiro Silva   +6 more
doaj   +1 more source