Results 41 to 50 of about 180,223 (258)

Toll-Like Receptor 4 Signaling and Drug Addiction [PDF]

Frontiers in Pharmacology, 2020
The emphasis of neuronal alterations and adaptations have long been the main focus of the studies of the mechanistic underpinnings of drug addiction. Recent studies have begun to appreciate the role of innate immune system, especially toll-like receptor 4 (TLR4) signaling in drug reward-associated behaviors and physiology.
Ruyan Wu, Ruyan Wu, Jun-Xu Li
openaire   +3 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation

Journal of Inflammation, 2012
Background Expression profile of the toll like receptors (TLRs) on PBMCs is central to the regulation of proinflammatory markers. An imbalance in the TLRs expression may lead to several types of inflammatory disorders. Furthermore, the dynamic regulation
Ahmad Rasheed, Al-Mass Anfal, Atizado Valerie, Al-Hubail Asma, Al-Ghimlas Fahad, Al-Arouj Monira, Bennakhi Abdullah, Dermime Said, Behbehani Kazem   +8 more
doaj   +1 more source

Dysregulation of Ovine Toll-Like Receptors 2 and 4 Expres-sion by Hydatid Cyst-Derived Antigens

Iranian Journal of Parasitology, 2021
Background: Cystic echinococcosis (CE) is a zoonotic disease caused by infection with Echinococcus granulosus. Toll-like receptors (TLRs) as the first line of defense against various parasites play a critical role in sensing and triggering anti-parasite ...
Nooshinmehr Soleymani, Fatemeh Taran, Mohammad Hossein Nazemshirazi, Aboulghasem Naghibi, Maryam Torabi, Hassan Borji, Alireza Haghparast   +6 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Cathelicidin (LL‐37) causes expression of inflammatory factors in coronary artery endothelial cells of Kawasaki disease by activating TLR4–NF‐κB–NLRP3 signaling

Immunity, Inflammation and Disease, 2023
Background Kawasaki disease (KD) is a type of vasculitis with an unidentified etiology. Cathelicidin (LL‐37) may be involved in the development of the KD process; therefore, further research to investigate the molecular mechanism of LL‐37 involvement in ...
Feifei Si, Yaheng Lu, Yizhou Wen, Tingting Chen, Yingzi Zhang, Yanfeng Yang   +5 more
doaj   +1 more source

Toll-Like Receptor-4 Modulation for Cancer Immunotherapy [PDF]

Frontiers in Immunology, 2014
Toll-like receptors (TLRs) are evolutionarily conserved pattern recognition molecules. Since the discovery of the Toll pathway cascade (1, 2), our knowledge about the structure, function, and mechanics of TLRs in infectious and inflammatory conditions has increased remarkably. The role of TLR4 as a pathogen-pattern recognition receptor has been studied
openaire   +3 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

THE ROLE OF INFLAMMATORY MEDIATORS AND TOLL-LIKE RECEPTORS IN NEWBORN BABIES WITH RESPIRATORY DISORDERS, WHO RECEIVE ARTIFICIAL LUNG VENTILATION

Медицинский вестник Юга России, 2013
Purpose: To study the role of pro-inflammatory and anti-inflammatory cytokines, Toll-like receptors in the pathogenesis of respiratory disorders in full-term newborns.Materials and methods.
M. V. Dudareva
doaj   +1 more source